Article
Sport Sciences
Stephanie K. Gaskell, Rebecca Burgell, Lukasz Wiklendt, Phil Dinning, Ricardo J. S. Costa
Summary: This study showed that running for 2 hours at 60% V?O2max in hot ambient conditions can affect gastric myoelectrical activity and orocecal transit time, leading to increased gastrointestinal symptoms incidence and severity in hot conditions.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2022)
Article
Physiology
Stephanie K. Gaskell, Rebecca Burgell, Lukasz Wiklendt, Phil G. Dinning, Ricardo J. S. Costa
Summary: The study aimed to determine the impact of exercise duration on gastrointestinal functional responses and symptoms. It found that exercise is associated with changes in gastric myoelectrical activity, leading to a reduction in gastric motility and slower gastric transit time. This may explain the high incidence and severity of exercise-associated gastrointestinal symptoms.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Microbiology
XiaoXue Tian, Yuanyuan Wu, Cheng Duan, Xiaohong Zhou, Yong Li, Jiabin Zheng, Weihua Lai, Shuyao Zhang, Lixiang Cao, Shilong Zhong
Summary: This study developed a method using in vitro culture bacteria to evaluate the effects of indole-3-butyric acid (IBA) on specific microbial metabolites quickly. Results showed that IBA increases the production of certain tryptophan (TRP) metabolites and inhibits the production of others. This new bacteria-specific in vitro model provides a flexible, reproducible, and cost-effective tool for researchers when developing innovative strategies for studying gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tina Okdahl, Anne-Marie Wegeberg, Anne Birthe Helweg Jensen, Sarah Thorius Jensen, Helene Riis Pontoppidan Andersen, Joachim Storling, Birgitte Brock, Christina Brock
Summary: Gastroenteropathy, a complication of diabetes, is associated with damage to the enteric nervous system. Systemic inflammation and neuropathy have been reported, but associations with gastroenteropathy are less known. This study explored these associations in individuals with diabetes and found that certain cytokines were associated with gastric and colonic transit times. Inverse correlations between cytokines and symptoms were also observed. These findings suggest a potential interaction between inflammation and the enteric nervous system in diabetes, highlighting the possibility of using anti-inflammatory strategies in managing diabetic gastroenteropathy.
Article
Multidisciplinary Sciences
Nobuhiro Nakazawa, Makoto Sohda, Kyoichi Ogata, Seded Baatar, Yasunari Ubukata, Kengo Kuriyama, Keigo Hara, Masaki Suzuki, Toru Yanoma, Akiharu Kimura, Norimichi Kogure, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Atsushi Oue, Erito Mochiki, Hiroyuki Kuwano, Ken Shirabe, Noriyuki Koibuchi, Hiroshi Saeki
Summary: This study investigated the relationship between thyroid function and gastrointestinal motility using an experimental dog model. The findings suggest that hypothyroidism inhibits gastrointestinal motility, while hyperthyroidism enhances it. Additionally, it was observed that thyroid hormone can activate upper gastrointestinal motility independently of gastrointestinal hormones.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Chethan Ramprasad, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Joseph Levy, Yian Zhang, Christy L. Spalink, Abraham Khan, Scott Smukalla, Horacio Kaufmann, Lea Ann Chen
Summary: Patients with familial dysautonomia (FD) exhibit higher prevalence of gastrointestinal symptoms compared to the general US adult population, but these symptoms are less severe in FD patients. Caregivers reported similar burden of symptoms as patients.
CLINICAL AUTONOMIC RESEARCH
(2021)
Article
Medicine, General & Internal
Davide Bertoli, Esben Bolvig Mark, Donghua Liao, Tina Okdahl, Serena Nauser, Louise Hostrup Daugberg, Christina Brock, Birgitte Brock, Filip Krag Knop, Klaus Krogh, Jens Brondum Frokjaer, Asbjorn Mohr Drewes
Summary: In this study, we evaluated the structural and functional GI parameters in diabetic patients and healthy controls using multi-segmental magnetic resonance imaging (MRI). We observed differences in stomach, small bowel, and colon volumes, as well as an adynamic small bowel in patients with diabetes and GI symptoms. Associations between recorded parameters and perceived symptoms were also explored. The findings suggest that MRI can be a useful tool for studying diabetes-induced GI symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Neza Brezovec, Katja Perdan-Pirkmajer, Blaz Burja, Ziga Rotar, Josko Osredkar, Snezna Sodin-Semrl, Katja Lakota, Sasa Cucnik
Summary: The balance between reactive oxygen species and antioxidant defense is disrupted in oxidative stress. This study examined the oxidative balance in systemic sclerosis (SSc) patients and healthy controls, and found high levels of reactive oxidative metabolites (ROMs) in both groups. However, SSc patients had significantly higher total antioxidant capacity (TAC) and oxidative stress index, indicating an increased antioxidant capacity. Although there was no difference in lipid peroxidation or oxidative DNA damage, SSc patients had more leukocyte DNA breaks, especially those treated with immunosuppressives.
Article
Physiology
Stephanie K. Gaskell, Christopher E. Rauch, Ricardo J. S. Costa
Summary: This translational research case series describes the implementation of a gastrointestinal assessment protocol during exercise (GastroAxEx) to inform individualised therapeutic intervention of endurance athletes affected by exercise-induced gastrointestinal syndrome (EIGS) and associated gastrointestinal symptoms (GIS). A four-phase approach was applied, focusing on clinical assessment, laboratory simulation of exercise stress, therapeutic intervention, and monitoring. The results showed individualised interventions based on the identified causal factors of EIGS and GIS during exercise led to improvements in symptoms and work output for athletes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Michael Camilleri
Summary: The objective of this article is to review the evidence of abnormal gastrointestinal (GI) tract motor functions in the context of disorders of gut-brain interaction (DGBI). The article describes preferred methods and documented motor dysfunctions in DGBI based on those methods for each section regarding GI motor dysfunction. Non-invasive measurements of gut motility and therapeutic interventions directed to abnormalities of motility suggest their consideration in patients with DGBI not responding to first-line approaches.
Review
Medicine, General & Internal
Zhipeng Zheng, Jingyi Tang, Yingnan Hu, Wei Zhang
Summary: The gut microbiota plays a significant role in regulating GI motility through interactions with the enteroendocrine system, enteric nervous system, intestinal smooth muscle, and immune system.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Zsuzsanna H. McMahan, Ana E. Tucker, Jamie Perin, Elizabeth R. Volkmann, Subhash Kulkarni, Harvey A. Ziessman, Pankaj J. Pasricha, Fredrick M. Wigley
Summary: The study found that abnormalities in gastrointestinal transit in SSc patients may contribute to increased gastrointestinal symptoms and severity, especially affecting the transit and emptying functions of the esophagus and colon.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Esben Bolvig Mark, Rasmus Bach Nedergaard, Tine Maria Hansen, Thomas Dahl Nissen, Jens Brondum Frokjaer, S. Mark Scott, Klaus Krogh, Asbjorn Mohr Drewes
Summary: In this study, tapentadol caused significantly less colonic dysmotility and gastrointestinal side effects compared to oxycodone in equianalgesic doses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Pharmacology & Pharmacy
Yan Tong, Jian Qing Huang, Yang Chen, Mei Tu, Wei Wang
Summary: This observational study aimed to assess the influence of GLP-1RA liraglutide and DPP-4i sitagliptin on bowel preparation in patients with type 2 diabetes. The results showed that these two drugs did not significantly increase the incidence of inadequate bowel preparation and gastrointestinal symptoms. However, liraglutide may increase the incidence of inadequate bowel preparation in patients with diabetic peripheral neuropathy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Bin Song, Jacob W. Feldmann, Shibo Cao, Melissa Feitosa, Youngbin Kong, Woori Kim, Altana Schweitzer, Pierre Leblanc, Jeffrey S. Schweitzer, Kwang-Soo Kim
Summary: The ak mouse is a suitable model for studying both motor and non-motor symptoms of Parkinson's disease (PD), including fine motor deficits, olfactory function deficits, and gastrointestinal dysfunction. It can also be used for the development of novel disease-modifying therapeutics.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Spectroscopy
Xiaobo Tian, Hjalmar P. Permentier, Rainer Bischoff
Summary: This article summarizes the advances in liquid chromatography and mass spectrometry in proteome quantification approaches, focusing on the principles, benefits, and limitations of chemical isotope labeling-based methods. It also discusses the potential and limitations of multiplex isotope labeling approaches for data-independent acquisition mode.
MASS SPECTROMETRY REVIEWS
(2023)
Article
Engineering, Biomedical
Akash Gupta, Janette K. Burgess, Theo Borghuis, Marcel P. de Vries, Jeroen P. Kuipers, Hjalmar Permentier, Rainer Bischoff, Dirk-Jan D. Slebos, Simon Pouwels
Summary: This study investigates the composition of the adhered proteome on explanted lung devices, which are widely used as mechanical interventions for pulmonary pathologies. The research reveals that long-term efficacy can be impacted by fibrotic or granulation tissue formation around the implant sites. The study identifies 263 unique protein species that are mutually adsorbed on the explanted lung devices, and pathway analyses suggest their association with coagulation, pattern recognition receptor signaling, immune responses, cytoskeleton organization, cell adhesion, and migration. The findings also highlight the importance of extracellular matrix proteins and damage-associated molecular patterns in the formation of the surface proteome.
ACTA BIOMATERIALIA
(2022)
Review
Gastroenterology & Hepatology
Barbora Waclawikova, Agnese Codutti, Karen Alim, Sahar El Aidy
Summary: The human gastrointestinal tract is populated by trillions of microbes that play a significant role in regulating intestinal physiology, including gut motility. Understanding the inter-regulatory mechanisms between the microbiota and bowel function is crucial for addressing gut dysmotility and associated diseases.
Article
Chemistry, Medicinal
Ali Alipour Najmi, Elchin Jafariyeh-Yazdi, Mojgan Hadian, Jos Hermans, Rainer Bischoff, Jun Yue, Alexander Domling, Arne Wittstock, Hjalmar P. Permentier
Summary: A novel method for selectively catalyzing the N-dealkylation of drug molecules on a nanoporous gold (NPG) catalyst is described, resulting in valuable metabolites and intermediates. Drug metabolites play a crucial role in drug discovery and development, providing information on the safety and ADME of new drug candidates.
Review
Food Science & Technology
Fan Liu, Anna Bella Simpson, Esmee D'Costa, Fanny Sophia Bunn, Sander S. van Leeuwen
Summary: The human brain grows rapidly in early life and requires adequate nutrition, with human milk providing optimal nutrition and breastfeeding improving cognition development. Sialic acid, a key molecule essential for brain development, is found in human milk oligosaccharides (HMOS). Dietary supplementation with sialic acid or sialylated oligosaccharides enhances intelligence and cognition performance. Furthermore, sialic acid is implicated in brain homeostasis and neurodegenerative diseases such as Alzheimer's disease.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Ecology
Pamela Gonzalez-Davila, Markus Schwalbe, Arpit Danewalia, Boushra Dalile, Kristin Verbeke, Sushil K. Mahata, Sahar El Aidy
Summary: The gut epithelium secretes antimicrobial peptides to control the action of gut microbes, and the microbes have evolved antimicrobial resistance mechanisms. This study found that the antimicrobial peptide CST can affect the diversity and composition of the gut microbiota, and it is related to the production of short-chain fatty acids by the microbiota. In addition, the study also found that a certain bacterium can degrade CST, and the gene abundance is higher in patients with Crohn's disease.
Article
Biochemistry & Molecular Biology
Yi Yu, Marianne van der Zwaag, Jouke Jan Wedman, Hjalmar Permentier, Niels Plomp, Xiu Jia, Bart Kanon, Ellie Eggens-Meijer, Girbe Buist, Hermie Harmsen, Jan Kok, Joana Falcao Salles, Bregje Wertheim, Susan J. Hayflick, Erick Strauss, Nicola A. Grzeschik, Hein Schepers, Ody C. M. Sibon
Summary: Coenzyme A (CoA) is essential for metabolism and protein acetylation. Current knowledge suggests that each cell obtains CoA through biosynthesis, but recent studies have shown the presence of additional CoA-generating mechanisms, indicating a more complex system for CoA homeostasis. In this study, researchers discovered pathways for CoA generation through inter-organismal flows of CoA precursors. Fruit flies with a genetic block in CoA biosynthesis were used to demonstrate that progeny can obtain CoA precursors from maternal sources for survival during embryonal and early larval development. Later in life, the microbiome can provide necessary CoA building blocks to the host, enabling normal development to continue. This study reveals the presence of stable, long-lasting CoA precursor flows between living organisms, indicating complex strategies for maintaining CoA homeostasis.
Review
Biochemistry & Molecular Biology
Ali Alipour Najmi, Rainer Bischoff, Hjalmar P. Permentier
Summary: N-dealkylation is an important chemical transformation for the synthesis of pharmaceuticals and chemicals, as well as a crucial metabolic pathway in vivo. The identification and synthesis of drug metabolites has significant implications in drug development studies.
Article
Biotechnology & Applied Microbiology
Xiangfeng Meng, Xiaodan Li, Tjaard Pijning, Xiaofei Wang, Sander S. van Leeuwen, Lubbert Dijkhuizen, Guanjun Chen, Weifeng Liu
Summary: This study revealed the potential of GH70 branching sucrases for glucosylating noncarbohydrate molecules. The (alpha 1 -> 3) branching sucrase GtfZ-CD2 was found to glucosylate benzenediol compounds and showed a preference for adjacent aromatic hydroxyl groups. Semirational engineering of GtfZ-CD2 variants improved the glucosylation efficiency of resorcinol and hydroquinone. This research provides insight into the mechanism of acceptor substrates binding and demonstrates the potential of using branching sucrase as an effective enzymatic glucosylation tool.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Toxicology
R. E. H. Karsten, N. J. W. Krijnen, W. Maho, H. Permentier, E. Verpoorte, P. Olinga
Summary: This study developed a mouse precision-cut liver slice model to study drug-induced cholestasis and assess its development. The findings show that cholestatic drugs increased intracellular bile-acid concentration and modulated bile-transporter genes. Chlorpromazine induced the most pronounced cholestasis and exhibited some transition into fibrosis.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Toxicology
Natalia Estrada-Ortiz, Viktoriia Starokozhko, Hidde van Steenwijk, Cor van der Heide, Hjalmar Permentier, Lisanne van Heemskerk, Grietje Harmanna Prins, Janette Heegsma, Klaas Nico Faber, Steffi Bressers, Guy Steiblen, Antoinette de Groot, Steve Groome, Erik van Miert, Geny Groothuis, Inge Anne Maria de Graaf
Summary: The biocide THPS and other members of THPX family are associated with liver toxicity and teratogenicity, possibly due to disturbances in retinol availability and metabolism caused by maternal toxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Chemistry, Organic
Daan V. Bunt, Sahar El Aidy, Adriaan J. Minnaard
Summary: The meroterpenoids fornicin A, fornicin D, and ganodercin D found in mushrooms of the Ganoderma genus were synthesized through a concise and divergent route. The unsaturated gamma-ketoacid moiety was obtained via an optimized step-wise aldol condensation. Additionally, a protocol for THP-protection of a phenolic hydroxyl group under basic conditions was developed, adding to the versatility of this protecting group.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Barbora Waclawikova, Paulo Cesar Telles de Souza, Markus Schwalbe, Constantinos G. Neochoritis, Warner Hoornenborg, Sieger A. Nelemans, Siewert J. Marrink, Sahar El Aidy
Summary: The gut-bacterial metabolite 5-hydroxyindole has been found to stimulate intestinal motility and can serve as a potential therapeutic for gastrointestinal motility disorders such as constipation. Oral administration of 5-hydroxyindole has minimal effects on the rat cecal microbiota. Molecular dynamics simulations suggest potential-binding pockets of 5-hydroxyindole in the L-type voltage-gated calcium channels, which have been associated with gastrointestinal motility disorders.
Article
Engineering, Environmental
Wen Zhou, Dana Irene Colpa, Hjalmar Permentier, Ruben Ate Offringa, Leon Rohrbach, Gert-Jan Willem Euverink, Janneke Krooneman
Summary: In this study, it was found that Schlegelella thermodepolymerans can produce up to 80% biodegradable polyhydroxyalkanoate (PHA) within 48 hours at 50 degrees C using 20 g/L xylose as substrate, a C/N ratio of 100, and an initial pH of 7. Metabolic pathways from xylose to PHA were identified, revealing the involvement of classic phaCAB, de novo fatty acid biosynthesis, and fatty acid β-oxidation. Additionally, it was shown that S. thermodepolymerans efficiently degraded extracellular PHA at 50 degrees C.
RESOURCES CONSERVATION AND RECYCLING
(2023)
Article
Microbiology
Sebastiaan P. van Kessel, Amber Bullock, Gertjan van Dijk, Sahar El Aidy
Summary: PD medication has significant effects on small intestinal motility, bacterial overgrowth, and microbiota composition, which may contribute to microbiota alterations observed in PD patients.
