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Cell Biology
Wenwen Dong, Bei Luo, Chang Qiu, Xu Jiang, Bo Shen, Li Zhang, Weiguo Liu, Wenbin Zhang
Summary: The study demonstrates that TRIM3 may attenuate cell apoptosis in Parkinson's disease by activating the PI3K/AKT signaling pathway, thereby improving cell viability in PD.
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Fisheries
Xuan lihui, Guo Jinming, Guan Yalin, Wang Hemeng, Wu Hao, Chang Ying
Summary: Profenofos (PFF) as an environmental pollutant can induce oxidative stress in hepatocytes, inhibit AKT phosphorylation, and activate mitochondrial apoptosis. Albicanol can significantly reduce the effects of PFF on grass carp hepatocytes by regulating the ROS/PTEN/PI3K/AKT pathway.
FISH & SHELLFISH IMMUNOLOGY
(2022)
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Oncology
Chunhui Nie, Bei Wang, Baoquan Wang, Ning Lv, Rui Yu, Enfan Zhang
Summary: The study revealed that protopine inhibits liver carcinoma cell viability by triggering apoptosis and suppressing the PI3K/Akt signaling pathway. In vivo experiments showed that protopine effectively repressed tumor growth without noticeable toxicity, indicating its potential as a therapeutic agent for liver carcinoma.
CANCER CELL INTERNATIONAL
(2021)
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Medicine, General & Internal
Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang, Yibo Mei, Jinlai Zhou, Minghai Ma, Jianbin Ma, Yue Chong, Xinyang Wang, Peng Guo, Dalin He, Jin Zeng
Summary: The study found that the novel 450-nm laser-mediated DVDMS-based photodynamic therapy (PDT) can inhibit and induce apoptosis in gastric cancer cells by producing excessive reactive oxygen species (ROS). Additionally, PDT also promoted apoptosis in gastric cancer cells through the autophagy pathway. Furthermore, the study identified the involvement of the ROS/PI3K/Akt/mTOR pathway in the regulation of PDT-induced autophagy.
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Environmental Sciences
Xiaoru Chang, Xiujuan Wang, Jiangyan Li, Mengting Shang, Shuyan Niu, Wenli Zhang, Yunjing Li, Zuoyi Sun, Junying Gan, Wenhua Li, Meng Tang, Yuying Xue
Summary: This study found that AgNPs can induce cytotoxicity in HT22 cells through autophagy and apoptosis pathways mediated by the PI3K/AKT/mTOR signaling pathway. These results provide experimental evidence and explanation for the potential neurotoxicity triggered by AgNPs in vitro.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Xiaoling Li, Meicui Chen, Zhicui Yao, Hongzhen Du, Tianfeng Zhang, Haiyue Wang, Ying Xie, Zengning Li
Summary: Jujuboside B (JUB) induces apoptosis of colorectal cancer cells by promoting ROS generation and inactivating the PI3K/Akt signaling pathway, leading to tumor growth inhibition.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Mydhili Govindarasu, Pari Abirami, Govindasamy Rajakumar, Mohammad Azam Ansari, Mohammad N. Alomary, Faris F. Aba Alkhayl, Abdulaziz A. Aloliqi, Muthu Thiruvengadam, Manju Vaiyapuri
Summary: Kaempferitrin shows promise as a potential therapeutic agent for colorectal cancer, as it inhibits cancer cell proliferation and induces apoptosis through the PI3K/AKT signaling pathway.
PROCESS BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Qimeng Xiao, Yuanhao Liu, Guizhi Jiang, Yuan Liu, Yan Huang, Wukun Liu, Zhenbo Zhang
Summary: In this study, a novel gold compound (Complex 10) was designed and synthesized, which showed strong anti-EC activity and outperformed the existing drug auranofin in cell, organoid, and xenograft models. Mechanistically, Complex 10 suppressed the expression of key proteins involved in EC development. These findings suggest the potential of Complex 10 as a treatment option for EC.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Xiaojuan Zhu, Shichao Liu, Zhijiao Cao, Lei Yang, Fang Lu, Yulan Li, Lili Hu, Xiaoliang Bai
Summary: Higenamine can alleviate IL-1 beta-induced apoptosis of HNPCs through ROS-mediated PI3K/Akt pathway. Higenamine affects the expression of Bcl-2, Bax, and cleaved caspase-3, but has no impact on ROS levels and PI3K/Akt signaling.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Sixuan Wang, Jun Duan, Jiangquan Liao, Yan Wang, Xiang Xiao, Lin Li, Yi Liu, Huan Gu, Peng Yang, Dongliang Fu, Jinhang Du, Xianlun Li, Mingjing Shao
Summary: The study reveals that lncRNAH19 can attenuate DCM in DM by reducing cardiomyocyte apoptosis and improving fibrosis. Additionally, H19 can repress ERS, oxidative stress, and apoptosis, and this effect may be achieved by inhibiting the activation of the PI3K/AKT/mTOR signaling pathway.
Article
Cell Biology
Kunlun Chen, Pengfei Zhu, Wenhui Chen, Kai Luo, Xiao-Jing Shi, Wenlong Zhai
Summary: Melatonin exerts antitumor effects on gallbladder cancer cells by inhibiting cell growth, migration, and invasion, inducing apoptosis, modulating apoptotic protein expression, increasing intracellular reactive oxygen species, and suppressing the PI3K/Akt/mTOR signaling pathway. In vivo and in vitro studies demonstrated that melatonin suppressed the growth of GBC-SD cells in an athymic nude mice xenograft model.
Article
Biochemistry & Molecular Biology
Jing Chen, Haimei Liu, Yichuan Chen, Huiyan Hu, Chunxia Huang, Yi Wang, Lijuan Liang, Yunjun Liu
Summary: In this article, two new iridium(III) complexes were synthesized and their anti-cancer activity was investigated. The results showed that these complexes induced apoptosis in BEL-7402 cells through ROS-mediated mitochondrial dysfunction and inhibition of the PI3K/AKT/mTOR signaling pathway.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xue-Min Shi, Wen-Yan She, Ting-Ting Liu, Lian-Xun Gao, Yu-Jiao Liu, Yi Liu
Summary: This study developed arsenicals by conjugating inhibitors with arsenical precursors, which effectively inhibited tumor growth and maintained a long-lasting presence in the body. These arsenicals eliminated tumors by inducing oxidative stress and apoptosis through the inhibition of the thioredoxin system, while restoring the hemogram to normal levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhiqi Lei, Ilyas Ali, Min Yang, Caixia Yang, Yifei Li, Lian Li
Summary: This study investigated the deleterious effects of NEFA on bovine granulosa cells and its underlying molecular mechanism using an in vitro model. The results showed that high levels of NEFA led to the accumulation of reactive oxygen species, increased apoptosis-related factors, and disrupted steroid hormone synthesis in BGCs. In addition, NEFA inhibited the PI3K/AKT pathway and increased FoxO1 expression. These findings help to clarify the molecular mechanisms underlying the negative effects of NEFA on BGCs.
Article
Plant Sciences
Zhihang Yuan, Mengran Yang, Zengenni Liang, Chenglin Yang, Xiangyi Kong, You Wu, Siqi Wang, Hui Fan, Can Ning, Wenguang Xiao, Zhiliang Sun, Jing Wu
Summary: Koumine, an indole alkaloid, has anti-inflammatory and antioxidant effects and can protect the intestine from injury. It mitigates H2O2-induced cell damage by enhancing cell viability and suppressing cell membrane fragmentation, as well as inhibiting the production of inflammatory factors. Additionally, koumine protects cells by preventing apoptosis and autophagy.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)