Article
Computer Science, Interdisciplinary Applications
Zhongzhi Jia, Junhao Mei, Wei Ding, Xi Zhao, Wen Gong, Haiyang Yu, Lihao Qin, Zeyu Piao, Wenhua Chen, Liming Tang
Summary: This study explored the role of hemodynamic factors in the occurrence of superior mesenteric artery dissection (SMAD) and identified histopathologic changes in the artery wall using a fluid-structure interaction simulation method. The results showed that increased aortomesenteric angle and SMA curvature were risk factors for SMAD, causing local hemodynamic abnormalities and histopathologic changes in the anterior wall of the SMA.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Engineering, Biomedical
Dan Lior, Charles Puelz, Colin Edwards, Silvana Molossi, Boyce E. Griffith, Ravi K. Birla, Craig G. Rusin
Summary: This paper presents a semi-automatic method for constructing volumetric models of the aortic valve using computed tomography angiography images. The method uses manually selected samples of the aortic segmentation derived from the images to inform the model construction. Valve models for pediatric patients are created and simulation results show that the method produces functional valves that generate pressure and flow waveforms similar to clinical observations.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Abdulgaphur Athani, Nik Nazri Nik Ghazali, Irfan Anjum Badruddin, Abdullah Y. Usmani, Sarfaraz Kamangar, Ali E. Anqi, Nandalur Ameer Ahammad
Summary: This article explores the influence of multi stenosis in a flexible and rigid left coronary artery model using two-way fluid-solid interaction (FSI) and numerical simulations. The study found that there is significant pressure drops and wall shear stress across severe stenosis, leading to increased blood flow velocity across the restricted regions and the formation of a recirculation zone at the post-stenosis and bifurcation regions. It was also observed that the rigid models tended to overestimate hemodynamic descriptors compared to the FSI models.
APPLIED SCIENCES-BASEL
(2021)
Article
Physics, Applied
Ryuhei Yamaguchi, Gaku Tanaka, Nadia Shaira Shafii, Kahar Osman, Yasutomo Shimizu, Khalid M. Saqr, Makoto Ohta
Summary: This study investigated the hemodynamics of an elastic aneurysm model using particle image velocimetry. The results showed that wall elasticity suppressed the magnitude of wall shear stress in the aneurysm and attenuated the flow fluctuation.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Engineering, Multidisciplinary
Daniel S. Morikawa, Mitsuteru Asai
Summary: This work introduces a two-way coupling technique between SPH method and EISPH technique for simulating fluid-structure interaction problems. The paper discusses the solid and fluid parts, coupling approach, stability methods, and validation through numerical tests and experimental data comparisons, highlighting the significance and details of the proposed methodology.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Louis Garber, Seyedvahid Khodaei, Nima Maftoon, Zahra Keshavarz-Motamed
Summary: In recent years, transcatheter aortic valve replacement (TAVR) has emerged as the leading method for treating aortic stenosis. However, there are still uncertainties about the impact of TAVR on coronary blood flow, and current technologies for non-invasive assessment of coronary blood flow are limited. This study presents a computational model that can simulate coronary blood flow and generate cardiovascular hemodynamic metrics, providing insight into the individual relationships between TAVR and mean and peak coronary flow rates.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Qinghe Yao, Hongkun Zhu, Weizhu Wang, Yongting Shen, Zhong Liu, Jinshan Wang, Zhongsong Shi
Summary: This study established a hemodynamics model of carotid artery stenosis in swine and validated the empirical function of WSS in the model. Comparison between rigid wall and elastic wall models showed that the elastic wall model performs better in representing experimental conditions, while the rigid wall model is more efficient.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Biology
Monika Colombo, Anna Corti, Diego Gallo, Andrea Colombo, Giacomo Antognoli, Martina Bernini, Ciara McKenna, Scott Berceli, Ted Vaughan, Francesco Migliavacca, Claudio Chiastra
Summary: This study analyzed the impact of stent design and stent overlapping on patient-specific SFA hemodynamics. The results showed that different stent designs and overlapping configurations significantly altered the hemodynamic parameters. Stent design type and overlapping length had a significant impact on the hemodynamics.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Nimmy Thankom Philip, Srinivas Bolem, B. J. Sudhir, B. S. V. Patnaik
Summary: This study investigates the influence of morphological features and hemodynamic forces on the rupture of cerebral aneurysms. Three different shapes of aneurysms are studied: spherical, beehive, and pear-shaped. The study compares these model aneurysms with patient-specific configurations. The results show that pear-shaped aneurysms may lead to atherosclerotic lesions, while beehive-shaped aneurysms are more prone to forming secondary blebs. Spherical aneurysms exhibit a stable flow field and uniform distribution of wall stresses, indicating a hemodynamically and bio-mechanically stable condition.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Byron A. Zambrano, Nathan McLean, Xiaodan Zhao, Ju-Le Tan, Liang Zhong, C. Alberto Figueroa, Lik Chuan Lee, Seungik Baek
Summary: The study found that patients with pulmonary arterial hypertension (PAH) have stiffer and larger pulmonary artery walls, reduced relative area change, higher total resistance, and lower total compliance. Additionally, PAH patients have lower wall shear stress values at the main pulmonary arteries.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Civil
Vishal Anand
Summary: This paper presents a systematic study on slender tubes made of hyperelastic materials, which are commonly found in soft robotics, biology, and industry. The behavior of the tube is modeled using five different constitutive laws, and the fluid-structure interaction problem is analyzed to obtain deformation and pressure profiles for different hyperelastic models. The results show that the behavior of the tubes varies depending on the hyperelastic model, with some exhibiting strain hardening and others exhibiting strain softening. A sensitivity analysis emphasizes the importance of geometrical nonlinearity in the problem.
THIN-WALLED STRUCTURES
(2023)
Article
Mathematics, Applied
Francois Demoures, Francois Gay-Balmaz
Summary: In this paper, a geometric variational discretization for nonlinear elasticity in 2D and 3D is introduced in the Lagrangian description. The discrete deformation gradients and discrete Cauchy-Green deformation tensors play an important role in constructing a general discrete geometric framework for frame indifferent isotropic hyperelastic models. This discrete framework is perfectly compatible with the multisymplectic discretization of fluids previously proposed by the authors. It allows for the development of a geometric variational discretization for the coupled dynamics of a fluid impacting and flowing on the surface of a hyperelastic body.
JOURNAL OF NONLINEAR SCIENCE
(2022)
Article
Medicine, General & Internal
Dona Adikari, Ramtin Gharleghi, Shisheng Zhang, Louisa Jorm, Arcot Sowmya, Daniel Moses, Sze-Yuan Ooi, Susann Beier
Summary: Coronary artery disease is the leading cause of death worldwide, with a high percentage of unexplained cardiovascular events. A new risk prediction method based on CT coronary angiography data and machine learning techniques is proposed to enable personalized preventive therapies for CAD.
Article
Engineering, Biomedical
Can Ozcan, Ozgur Kocaturk, Civan Islak, Cengizhan Ozturk
Summary: This study introduced a low-cost, patient-specific in vitro AAA model to investigate hemodynamics, validated through FSI simulations. The experimental setup replicated physiological conditions and showed deviations in wall deformations and flow velocities compared to FSI simulations. Pulsatile flow conditions demonstrated a strong correlation in flow velocities and vectors, while transient phenomena were consistently depicted between experimental and numerical models.
BIOMEDICAL ENGINEERING ONLINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sophia Back, Iulia Skoda, Jonas Lantz, Lilian Henriksson, Lars O. Karlsson, Anders Persson, Carl-Johan Carlhall, Tino Ebbers
Summary: This study compared blood flow and stasis in the left atrium between patients with paroxysmal atrial fibrillation (AF) and controls using computational fluid dynamics (CFD) simulations. The results showed that residence time was significantly elevated in the AF group and was strongly associated with left atrial ejection ratio and the ratio of left atrial volume to left ventricular stroke volume. These findings suggest that stroke risk due to left atrial thrombi might be increased in AF patients even during sinus rhythm. Patient-specific CFD simulations could potentially improve the assessment and support the diagnosis and treatment for AF patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biophysics
J. Feng, A. W. Khir
JOURNAL OF BIOMECHANICS
(2010)
Article
Engineering, Biomedical
Jiling Feng, Nannan Wang, Yiliang Wang, Xiaoxian Tang, Jie Yuan
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2020)
Article
Mechanics
D. Y. Wang, X. Y. Luo, P. S. Stewart
Summary: This study examines flow in a finite-length collapsible channel with the presence of an elastic beam and external pressure using the finite element method. The system can simultaneously exhibit two stable static configurations and has a narrow region where multiple stable states can occur. The instabilities in both upper and lower branches during oscillations require an increase in work done by the upstream pressure to overcome increased dissipation.
JOURNAL OF FLUID MECHANICS
(2021)
Article
Engineering, Biomedical
M. Abdulsalam, J. Feng
Summary: This study aims to distinguish between stable and unstable artery plaques by analyzing the relationship between plaque composition and arterial waveforms. The experimental results indicate a strong correlation between plaque compositions and reflected waveforms, with collagen percentage linearly correlated with the amplitude of the backward diameter, lipid content showing a strong negative correlation with the backward diameter, and a slight weak correlation existing between reflected waveform and calcium percentage.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Mechanics
Danyang Wang, Xiaoyu Luo, Peter S. Stewart
Summary: This paper investigates flow through a channel with a unique structure, demonstrating the possibility of three steady states and analyzing the stability and instability of the system. By adjusting different parameters, the study showcases the varying stability and oscillatory characteristics of the system.
INTERNATIONAL JOURNAL OF APPLIED MECHANICS
(2021)
Article
Biophysics
Ran He, Liguo Zhao, Vadim V. Silberschmidt, Jiling Feng, Ferdinand Serracino-Inglott
Summary: The personalised nitinol stent designs show significant improvements in lumen gain, reduction of stress levels in the media layer, and enhancement of lumen shape compared to the commercial stent design. This pilot study highlights the potential of personalised stents in delivering desirable treatment outcomes.
JOURNAL OF BIOMECHANICS
(2022)
Article
Materials Science, Coatings & Films
J. Feng, Y. Qin, T. W. Liskiewicz, B. D. Beake, S. Wang
Summary: This study aimed to investigate the fatigue failure mechanism of coated substrates by observing crack initiation and propagation. Results showed that cracks initiated at the edge of the contact area and rapidly propagated through the coating layer. The irreversible cohesive zone model was effective in predicting the coating system's loading bearing capacity under contact fatigue loading conditions.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Chemistry, Physical
Parastoo Jamshidi, Chinnapat Panwisawas, Enzoh Langi, Sophie C. Cox, Jiling Feng, Liguo Zhao, Moataz M. Attallah
Summary: This study investigates the potential of additive manufacturing for customised vascular stents and explores the impact of process parameters on the stent geometry. The study successfully manufactures Nitinol stents via laser powder bed fusion and demonstrates the importance of laser energy input in controlling the transformation temperatures and morphology of the stents.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Mechanics
Danyang Wang, Xiaoyu Luo, Zishun Liu, Peter S. Stewart
Summary: This study investigates the stability of laminar high-Reynolds-number flow in a planar channel with a rigid wall and a heavy compliant wall under longitudinal tension. Numerical simulations reveal the presence of two unstable normal modes, namely the Tollmien-Schlichting (TS) mode and a surface-based mode known as flow-induced surface instabilities (FISI), specifically travelling wave flutter (TWF) and static divergence (SD). The system exhibits TWF instability when there is no wall damping, and SD instability when wall damping exceeds a critical value. The Reynolds-Orr analysis shows that both FISI are primarily driven by normal stress on the flexible wall, with the SD mode having negative activation energy and the upper-branch SD approaching zero activation energy for large wall damping. Additionally, the interaction between TS and TWF modes results in stable islands within unstable regions of parameter space for large wall mass.
JOURNAL OF FLUID MECHANICS
(2023)