期刊
TRANSPLANTATION AND CELLULAR THERAPY
卷 27, 期 1, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2020.10.001
关键词
Aplastic anemia; Cytomegalovirus; Allogeneic hematopoietic stem cell transplantation; Survival
资金
- JSPS KAKENHI [18H02840]
- Grants-in-Aid for Scientific Research [18H02840] Funding Source: KAKEN
CMV reactivation is a major complication following allogeneic hematopoietic stem cell transplantation, with potential negative impact on post-transplant outcomes. The study showed that CMV reactivation is an independent risk factor for poor post-transplant outcomes in patients with aplastic anemia, especially in certain age groups and stem cell sources. Effective management strategies to suppress CMV reactivation early post-transplantation are needed to improve outcomes, particularly in high-risk patients.
Cytomegalovirus (CMV) infection is a major infectious complication following an allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recent large-scale retrospective studies reported that CMV reactivation is an independent risk factor for poor post-transplant outcomes, although the development of CMV end-organ disease is suppressed by the CMV antiviral preemptive therapy, which has been mainly analyzed for hematopoietic malignancies, such as acute leukemia. However, it remains unclear whether CMV reactivation also has a negative effect on post-transplant outcomes in aplastic anemia (AA). Therefore, we evaluated the clinical relevance of CMV reactivation in patients with AA using the registry database of the Japan Society for Hematopoietic Cell Transplantation. Adult patients with AA who underwent their first allo-HSCT between 2005 and 2017 and who survived with neutrophil engraftment until 100 days post-transplantation were analyzed (n = 672). Patients were monitored using pp65 antigenemia since the time of engraftment, and CMV reactivation in the analysis of this study was defined as the beginning of CMV preemptive or definitive therapy within 100 days post-transplantation. CMV reactivation occurred in 372 (55%) patients, including 19 with CMV end-organ disease. In time-dependent multivariate analysis, patients aged similar to 40 years (hazard ratio [HR], 1.89; P =.003) who underwent transplantation from HLA-matched related peripheral blood stem cells (HR, 2.85; P =.008), HLA-matched unrelated bone marrow (BM) (HR, 2.01; P =.036), and other stem cell sources (HR, 2.32; P =.007) compared to HLA-matched related BM, CMV reactivation (HR 1.65; P =.042), grade II to IV acute graft-versus-host disease (HR 1.73; P =.013), and secondary graft failure (HR 7.09; P <.001) had independent risk factors that significantly decreased overall survival, indicating that CMV reactivation, one of the early events at post-transplantation, had a significant negative impact on the long-term prognosis at post-transplantation. This effect was more pronounced in patients aged similar to 40 years who received a graft from other than HLA-matched related BM. Comparing the causes of death with and without CMV reactivation, no significant difference in the frequency of each cause of death was observed between the 2 groups (P =.453). Improvement of post-transplant CMV management that effectively suppresses CMV reactivation in the early stage at posttransplantation will be required to improve post-transplant outcomes, especially in high-risk patients. (C) 2020 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
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