Article
Immunology
Kengo Inagaki, Chad Blackshear, Paul A. Burns, Charlotte Hobbs
Summary: This study found significant differences in the risk of bronchiolitis hospitalization among infants of different races/ethnicities in New York State, with Hispanic and Black infants having the highest rates of hospitalization, while Asian infants had a lower risk. Further research and culturally appropriate public health interventions are needed to reduce racial and ethnic health disparities in bronchiolitis.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Dany Habr, Roxanne Ferdinand
Summary: Racial/ethnic minority groups are disproportionately impacted by cancer but are underrepresented in clinical trials. Strategies are needed to ensure diversity in trials and properly interpret risk/benefit of emerging therapies.
Article
Biophysics
Aaron Pruitt, Feng Gao, Elisa De Togni, Hunter Cochran, Sonia Godbole, Michael Slade, Ramzi Abboud
Summary: This study retrospectively analyzed outcomes in 299 patients who underwent peripheral blood haplo-HCT with PTCy and investigated the association with donor characteristics. The results showed that increasing donor age was associated with higher non-relapse mortality but lower relapse risk. Other donor factors including relationship and HLA match grade were not associated with outcomes.
BONE MARROW TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Jeremy Epah, Gabriele Spohn, Kathrin Preiss, Markus M. Mueller, Johanna Doerr, Rainer Bauer, Shabnam Daqiq-Mirdad, Joachim Schwaeble, Stefanie N. Bernas, Alexander H. Schmidt, Erhard Seifried, Richard Schaefer
Summary: This study found that the collection efficiency of bone marrow (BM) samples varies greatly worldwide. The implementation of a small volume aspirate policy improved the total nucleated cell yields in BM products. The impact of the BM collection technique on the quality of hematopoietic progenitor cell-manufacture was assessed.
Article
Urology & Nephrology
Navdeep Tangri, Vandana Mathur, Nancy Reaven, Susan E. Funk, Donald E. Wesson
Summary: Metabolic acidosis is associated with chronic kidney disease (CKD) progression and mortality. The incidence of metabolic acidosis is higher in Asian, Black, and Hispanic individuals, but residing in higher education zip codes mitigates this risk. Metabolic acidosis is independently associated with adverse outcomes in CKD patients across all racial/ethnic groups.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Oncology
Elena Kum, Gabriele Jagelaviciute, Edward Li, Kenneth Williams, Santhosh Thyagu, Warren Fingrut
Summary: The article tells the story of a Canadian stem cell recipient who underwent transplantation from a matched unrelated donor for refractory chronic myelogenous leukemia, showcasing different perspectives and encouraging people to become donors.
Article
Hematology
Curtis Marcoux, David Marin, Jeremy Ramdial, Gheath AlAtrash, Amin M. Alousi, Betul Oran, Partow Kebriaei, Uday R. Popat, Katayoun Rezvani, Richard E. Champlin, Elizabeth J. Shpall, Rohtesh S. Mehta
Summary: Optimal donor selection is crucial in allogeneic hematopoietic cell transplantation, and this study compares the outcomes of patients who received transplants from younger haploidentical donors or older matched unrelated donors. The use of younger haploidentical donors was associated with improved survival and lower rates of GVHD compared to older MUDs. These findings support the use of younger haploidentical donors with post-transplant cyclophosphamide in patients with MDS or AML.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Immunology
Wensheng Zhang, Yong Wang, Fushun Zhong, Xinghuan Wang, Robert Sucher, Cheng-Hung Lin, Gerald Brandacher, Mario G. G. Solari, Vijay S. S. Gorantla, Xin Xiao Zheng
Summary: In this study, using rodent vascularized composite allotransplantation (VCA) models, it was demonstrated that the presence of donor-derived hematopoietic stem cell (HSC) niches in vascularized bone components facilitates long-term hematopoietic chimerism and promotes tolerance in recipients without harsh myeloablation. The transplanted donor HSC niches also contribute to the maintenance and homeostasis of stable mixed chimerism. Additionally, evidence was provided that chimeric thymus plays a role in the tolerance induced by mixed chimerism through thymic central deletion. This study suggests the potential use of vascularized donor bone with pre-engrafted HSC niches as a safe and effective strategy to induce robust and stable mixed chimerism-mediated tolerance in vascularized composite allotransplantation or solid organ transplantation recipients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Franco Locatelli, Alexis A. Thompson, Janet L. Kwiatkowski, John B. Porter, Adrian J. Thrasher, Suradej Hongeng, Martin G. Sauer, Isabelle Thuret, Ashutosh Lal, Mattia Algeri, Jennifer Schneiderman, Timothy S. Olson, Ben Carpenter, Persis J. Amrolia, Usanarat Anurathapan, Axel Schambach, Christian Chabannon, Manfred Schmidt, Ivan Labik, Heidi Elliot, Ruiting Guo, Mohammed Asmal, Richard A. Colvin, Mark C. Walters
Summary: The study demonstrates that betibeglogene autotemcel therapy can achieve transfusion independence in patients with transfusion-dependent beta-thalassemia, with good safety profile and stable results, suitable for most patients with non-beta(0)/beta(0) genotype.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Matt Pelton, Paddy Ssentongo, Ashley Sun, Destin Groff, Shannon Dalessio, Kofi Clarke
Summary: Randomised controlled trials on Crohn's disease often lack representation from marginalized racial and ethnic populations, with over half of the trials failing to report any demographic data related to race/ethnicity. Among the trials that do report such data, there is a noticeable underrepresentation of Black, Native American/Pacific Islander, and Hispanic patients. Efforts should be made to increase reporting of racial and ethnic demographics and improve recruitment and retention of marginalized populations.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Hematology
Amy E. DeZern, Marianna Zahurak, Heather J. Symons, Kenneth R. Cooke, Carol Ann Huff, Tania Jain, Lode J. Swinnen, Philip H. Imus, Nina D. Wagner-Johnston, Richard F. Ambinder, Mark Levis, Leo Luznik, Javier Bolanos-Meade, Ephraim J. Fuchs, Richard J. Jones, Robert A. Brodsky
Summary: Severe aplastic anemia (SAA) is a marrow failure disorder with high morbidity and mortality. This study found that reduced-intensity conditioning HLA-haploidentical bone marrow transplantation (BMT) with posttransplantation cyclophosphamide (PTCy)-based graft-versus-host (GVHD) prophylaxis resulted in 100% overall survival and minimal GVHD in patients with SAA. This approach not only avoids the adverse effects of immunosuppressive therapy, but also expands access to BMT across all populations.
Article
Orthopedics
Christopher N. Carender, David E. DeMik, Jacob M. Elkins, Timothy S. Brown, Nicholas A. Bedard
Summary: This study evaluates the disparity in patient eligibility for primary total hip arthroplasty (THA) and total knee arthroplasty (TKA) based on race, ethnicity, and gender in the United States. The findings suggest that using BMI cutoffs alone to determine eligibility for surgery may disproportionately exclude women, Black persons, and Hispanic persons.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Immunology
Justin C. Quon, Kelli Kaneta, Nicholas Fotiadis, Jondavid Menteer, Rachel M. Lestz, Molly Weisert, Lee Ann Baxter-Lowe
Summary: This study investigated the prevalence and potential impact of unrepresented HLA proteins in different ethnic populations, and found a higher number of unrepresented HLA alleles in non-European populations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Jodi K. McCloskey, Jennifer L. Ellis, Connie S. Uratsu, Melanie L. Drace, James D. Ralston, Elizabeth A. Bayliss, Richard W. Grant
Summary: Communities of color have higher rates of SARS-COV-2 infection compared to non-Latino White communities, even after controlling for medical and social factors.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jialing Jiang, Christopher M. Warren, Audrey Brewer, Gary Soffer, Ruchi S. Gupta
Summary: This survey study aimed to estimate the national distribution of food allergies across racial, ethnic, and socioeconomic groups in the US. The results showed that the prevalence of food allergies was highest among Asian, Hispanic, and non-Hispanic Black individuals compared with non-Hispanic White individuals. The study suggests further assessment of socioeconomic factors and corresponding environmental exposures to better understand the causes of food allergy and reduce disparities in outcomes.