Review
Cell Biology
Konradin F. Muskens, Caroline A. Lindemans, Mirjam E. Belderbos
Summary: GvHD is a major complication of HCT, causing severe hematopoietic dysfunction. Immune activation during GvHD damages hematopoietic stem cells and their niche in the bone marrow, leading to reduced functionality. Complications and treatments associated with HCT exacerbate hematopoietic dysfunction.
Article
Immunology
Thomas Krueger, Rebekka Wehner, Maik Herbig, Martin Kraeter, Michael Kramer, Jan Moritz Middeke, Friedrich Stoelzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlaegel, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Joehrens, Torsten Tonn, Julien Subburayalu, Marc Schmitz, Martin Bornhauser, Malte von Bonin
Summary: Functional impairment of the bone marrow niche, particularly a decrease in mesenchymal stromal cells (MSCs), is associated with cytopenia and graft failure after hematopoietic cell transplantation. Acute graft-versus-host disease (aGvHD) is shown to significantly reduce MSC numbers, and this reduction can be observed before clinical onset of aGvHD. The different phenotypic and functional characteristics of MSCs depending on the occurrence of aGvHD suggest that they may contribute to alloreactivity after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Erika S. Varady, L. Angel Ayala, Pauline U. Nguyen, Vanessa M. Scarfone, Alborz Karimzadeh, Cuiwen Zhou, Xiyu Chen, Scott A. Greilach, Craig M. Walsh, Matthew A. Inlay
Summary: Donor cell conditioning with the glucocorticoid fluticasone propionate (FLU) prior to transplantation increases HSC engraftment and reduces the severity and incidence of graft-versus-host disease (GvHD) in allogeneic hosts.
EMBO MOLECULAR MEDICINE
(2023)
Article
Surgery
Cecile Chague, Thomas Gautier, Ludivine Dal Zuffo, Jean-Paul Pais de Barros, Audrey Wetzel, Georges Tarris, Gaetan Pallot, Laurent Martin, Severine Valmary-Degano, Valerie Deckert, Laurent Lagrost, Etienne Daguindau, Philippe Saas
Summary: This study found that HDL deficiency leads to LPS accumulation and exacerbates aGVHD. However, administration of HDL isolated from human plasma significantly decreases the mortality and severity of aGVHD. HDL infusion also plays an important role in mitigating liver aGVHD by reducing immune infiltration and inflammation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Pooja Khandelwal, Rosa F. Yeh, Louie Yu, Adam Lane, Christopher E. Dandoy, Javier El-Bietar, Stella M. Davies, Michael S. Grimley
Summary: The addition of abatacept to standard acute GVHD prophylaxis effectively reduced the incidence of severe acute GVHD in children with beta-thalassemia major undergoing HSCT, without affecting engraftment. Thalassemia-free survival was significantly higher in the abatacept group compared to the standard group.
Article
Immunology
Qianqian Wang, Xiuhua Su, Yi He, Mei Wang, Donglin Yang, Rongli Zhang, Jialin Wei, Qiaoling Ma, Weihua Zhai, Aiming Pang, Yong Huang, Sizhou Feng, Christie M. Ballantyne, Huaizhu Wu, Xiaolei Pei, Xiaoming Feng, Mingzhe Han, Erlie Jiang
Summary: Blocking CD11c inhibits T cell proliferation and differentiation into Th1 cells, playing crucial roles in aGVHD pathogenesis. CD11c deficiency alleviates aGVHD symptoms by affecting antigen presentation of DCs.
Review
Immunology
Kilian Kelly, John E. J. Rasko
Summary: GvHD is a life-threatening complication of hematopoietic stem cell transplantation, often requiring high-dose corticosteroid treatment. MSCs show promise as a potential therapy due to their immunosuppressive and immunoregulatory effects, but their efficacy may be influenced by donor variability and manufacturing processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yan Man, Zhixiang Lu, Xiangmei Yao, Yuemin Gong, Tonghua Yang, Yajie Wang
Summary: PGF is a life-threatening complication that occurs after transplantation and predicting and preventing it remains challenging. This study finds that CD34(+) cells, bone marrow microenvironment, and factors like viral infection and iron overload are closely related to the occurrence of PGF. The article summarizes the common risk factors and potential mechanism of PGF, as well as discusses the safety and efficacy of new strategies for treating it.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hui Li, Qi Liu, Xiaofeng Gao, Di Zhang, Shengjun Mao, Yongqian Jia
Summary: The study explored the potential of human umbilical mesenchymal stem cells transfected with IFN-γ gene and found that this treatment significantly reduced the incidence and severity of GVHD in vivo, providing a significant survival benefit.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Andrei Mircea Vacaru, Ana-Maria Mazilu, Madalina Dumitrescu, Ioana Madalina Fenyo, Anca Violeta Gafencu, Ana-Maria Vacaru
Summary: This study found that treatment with FasL-overexpressing MSC can improve GvHD and increase survival in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Shota Shimizu, Shinri Sato, Hiroko Taniguchi, Eisuke Shimizu, Jingliang He, Shunsuke Hayashi, Kazuno Negishi, Yoko Ogawa, Shigeto Shimmura
Summary: The study observed the dynamics of inflammatory cells in the cornea of chronic GVHD model mice, discovering that neovascularization occurred in all eyes at 1 week after BMT but almost all vessels disappeared at 2 weeks after BMT. Additionally, infiltration of globular cells and tortuosity and branching of nerves were found in both cGVHD mice and human cGVHD patients.
Article
Immunology
Zhigang Liu, Qiang Zeng, Xinchuan Chen, Chuan He, Fangfang Wang, Ting Liu
Summary: Donor peritoneal-derived cells can attenuate graft-versus-host disease (GVHD) caused by bone marrow transplantation by regulating cytokine levels and immunocyte ratios.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Hematology
Rajat Kumar Agarwal, Rakesh Dhanya, Amit Sedai, Kumari Ankita, Lalith Parmar, Stalin Ramprakash, Deepa Sandeep, Deepa Trivedi, Vaibhav Shah, Neema Bhat, Mohan Reddy, R. Nithya, Lawrence Faulkner
Summary: Bone marrow continues to be the preferred source of stem cells in allogenic transplantation, and G-CSF-primed bone marrow is effective in reducing acute graft-versus-host disease. This study evaluated the utility of a novel indicator, the Bone Marrow Quality Index (BMQI), to predict acute graft-versus-host disease.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Medicine, General & Internal
J. Bolanos-Meade, M. Hamadani, J. Wu, M. M. Al Malki, M. J. Martens, L. Runaas, H. Elmariah, A. R. Rezvani, M. Gooptu, K. T. Larkin, B. C. Shaffer, N. El Jurdi, A. W. Loren, M. Solh, A. C. Hall, A. M. Alousi, O. H. Jamy, M. -A. Perales, J. M. Yao, K. Applegate, A. S. Bhatt, L. S. Kean, Y. A. Efebera, R. Reshef, W. Clark, N. L. DiFronzo, E. Leifer, M. M. Horowitz, R. J. Jones, S. G. Holtan
Summary: This study compared the efficacy of two prophylaxis regimens for graft-versus-host disease (GVHD) in patients with hematologic cancers. The results showed that patients receiving cyclophosphamide-tacrolimus-mycophenolate mofetil had significantly higher GVHD-free, relapse-free survival at 1 year compared to those receiving tacrolimus-methotrexate.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Hematology
Jason P. Cooper, Janis L. Abkowitz
Summary: Acute graft-versus-host disease (GVHD) is a rare but life-threatening complication after solid organ transplantation. It is caused by the activation of donor leukocytes against recipient tissues and can affect various organs. The diagnosis of GVHD is often delayed and requires biopsy confirmation. Treatment involves systemic corticosteroids and adjustment of immunosuppression levels. In this article, 3 cases of GVHD after solid organ transplantation are described, and the approach to diagnosis and management is discussed.
Review
Medicine, General & Internal
Pinki Mishra, Rizwana Parveen, Ram Bajpai, Mohammed Samim, Nidhi Bharal Agarwal
Summary: Cardiovascular disease is significantly associated with severity and mortality in COVID-19 patients, as well as other comorbidities such as diabetes, hypertension, and chronic kidney disease. Further prevalence studies are needed to understand the full extent of these risk factors.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2021)
Article
Behavioral Sciences
Ubedul Hoda, Seema Jain, Mohammed Samim, Gaurav Kumar Jain, Nidhi Bharal Agarwal
Summary: The study showed that Embelin can suppress epileptogenesis through modulation of neurotransmitters and inhibition of inflammatory pathways, while also protecting against cognitive and depression-like behaviors.
EPILEPSY & BEHAVIOR
(2021)
Article
Endocrinology & Metabolism
Kanchan Tyagi, Nidhi Bharal Agarwal, Prem Kapur, Sunil Kohli, Rajinder K. Jalali
Summary: The study found that T2DM obese patients may be more prone to developing stress and depression, and adiponectin and cortisol could be potential biomarkers for T2DM, aiding in the early diagnosis of these comorbid conditions.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biology
Abida Parveen, Sultan Zahiruddin, Nidhi Agarwal, Muhammad Akhtar Siddiqui, Shahid Husain Ansari, Sayeed Ahmad
Summary: The herbal combination of TC, PE, and PN exhibited synergistic effects in inhibiting immune cells proliferation, suppressing pro-inflammatory mediators, and showing antioxidant activity. It improved immune markers, hematogram parameters, and histological parameters with maximum protection offered by an intermediate dose, suggesting its potential as a therapeutic approach for immune modulation.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Shweta Sharma, Md Sarfaraj Hussain, Nidhi B. Agarwal, Dinesh Bhurani, Mohd Ashif Khan, Md Aejaz Ahmad Ansari
Summary: This systematic review evaluated the efficacy of sirolimus for treatment of autoimmune cytopenias, particularly ALPS. The majority of ALPS patients showed rapid, complete, and durable responses with recovery of their primary disease manifestations, as well as stabilization of lymphoproliferation and a decrease in abnormal DNT cells. Sirolimus was found to be safe with few side effects that could be tolerated well, supporting its chronic use for the treatment of ALPS.
EXPERT OPINION ON ORPHAN DRUGS
(2021)
Article
Clinical Neurology
Saima Khatoon, Nidhi Bharal Agarwal, Mohammed Samim, Ozair Alam
Summary: This study demonstrates that fisetin exhibits neuroprotective effects in experimental epilepsy by suppressing the release of inflammatory and apoptotic molecules and attenuating histological alterations.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Yasmeen, Mohammad Kashif Iqubal, Mohd Ashif Khan, Nidhi B. Agarwal, Javed Ali, Sanjula Baboota
Summary: Skin carcinoma is a serious global disease, with synthetic chemotherapeutic drugs being effective but causing more adverse effects and drug resistance. Phytopharmaceuticals, on the other hand, target multiple molecular pathways without affecting healthy cells, making them the future of skin cancer treatment. Nano-based drug delivery improves the efficiency and safety of phytopharmaceuticals by enhancing bioavailability and specific targeting at the disease site.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Pallavi Kaushik, Mohd Ashif Khan, Nidhi B. Agarwal, Aakriti Garg
Summary: This systematic review assessed the effects of interferon-alpha (IFN-alpha) on cognitive functioning in patients suffering from hepatitis C virus (HCV). Conflicting results were observed regarding the use of IFN-alpha and the risk of neurocognitive impairment in HCV patients. Therefore, further extensive studies are urgently needed to evaluate the exact association between IFN-alpha therapy and cognitive functioning in HCV patients.
CURRENT DRUG SAFETY
(2023)
Article
Neurosciences
Mohd Ashif Khan, Dinesh Bhurani, Ubedul Hoda, Nouroz Sehar, Nidhi Agarwal
Summary: This study observed the effects of FAC, CEF, and CMF chemotherapy regimens on cognition and circulating proinflammatory cytokines IL-6 and IL-1β in breast cancer patients. The results showed that anthracycline-based regimen increased IL-6 and IL-1β levels and caused more decline in cognition compared to non-anthracycline-based regimens.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2022)
Review
Microbiology
Madhura Roy, Sonali Karhana, Md Shamsuzzaman, Mohd. Ashif Khan
Summary: Fungal infections pose a growing threat to individuals, necessitating research to develop new therapeutic options. Existing antifungal drugs have limitations such as toxicity, drug interactions, and resistance development, leading to significant mortality and morbidity. This review article discusses the challenges associated with current therapies and the development of new treatments, including ongoing clinical trials, for fungal infections.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Rohan Chakraborty, Rizwana Parveen, Prabhat Varshney, Prem Kapur, Saima Khatoon, Nilanjan Saha, Nidhi B. Agarwal
Summary: Inflammatory cytokines such as IL-36 alpha have been implicated in the pathogenesis of diabetic nephropathy, with levels significantly elevated in T2DM patients with DN. IL-36 alpha levels were found to correlate positively with urinary albumin excretion, HbA1c, and fasting plasma glucose, and negatively with glomerular filtration rate. Further extensive studies are recommended to evaluate this association.
MINERVA ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Aarzoo, Saba Naqvi, Nidhi Bharal Agarwal, Manoj P. Singh, M. Samim
Summary: The study found that bio-engineered palladium nanoparticles have significant toxic effects on murine macrophage cell lines, causing cell membrane damage and apoptosis at high doses. Results show that the toxicity of palladium nanoparticles is dependent on both time and dosage.