期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1866, 期 10, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2020.165834
关键词
Mitochondria-associated membranes (MAM); Mitochondria; Endoplasmic reticulum; Cancer; Oncogenes; Oncosuppressors
资金
- Polish National Science Centre [UMO-2015/17/D/NZ1/00030, UMO-2018/29/B/NZ1/00589]
- FOIE GRAS project
- mtFOIE GRAS project
- European Union's Horizon 2020 Research and Innovation programme under the Marie SklodowskaCurie Grant [722619, 734719]
- Italian Association for Cancer Research (AIRC) [IG-23670]
- Telethon Foundation [GGP11139B]
- Progetti di Rilevante Interesse Nazionale (PRIN) [2017 E5L5P3]
- University of Ferrara
Mitochondria-associated membranes (MAM), physical platforms that enable communication between mitochondria and the endoplasmic reticulum (ER), are enriched with many proteins and enzymes involved in several crucial cellular processes, such as calcium (Ca2+) homeostasis, lipid synthesis and trafficking, autophagy and reactive oxygen species (ROS) production. Accumulating studies indicate that tumor suppressors and oncogenes are present at these intimate contacts between mitochondria and the ER, where they influence Ca2+ flux between mitochondria and the ER or affect lipid homeostasis at MAM, consequently impacting cell metabolism and cell fate. Understanding these fundamental roles of mitochondria-ER contact sites as important domains for tumor suppressors and oncogenes can support the search for new and more precise anticancer therapies. In the present review, we summarize the current understanding of basic MAM biology, composition and function and discuss the possible role of MAM-resident oncogenes and tumor suppressors.
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