期刊
COMPTES RENDUS CHIMIE
卷 19, 期 1-2, 页码 19-27出版社
centre Mersenne pour ldition scientifique ouverte
DOI: 10.1016/j.crci.2015.12.004
关键词
Drug design; Protein-protein interaction; Structure; Small molecule; Antibody; Peptide; Peptidomimetic
资金
- CEA (Radiobiology program)
- Agence Nationale de la Recherche (CHAPINHIB)
- French Infrastructure for Integrated Structural Biology (FRISBI) [ANR-10-INSB-05-01]
- canceropole
- La Ligue contre le cancer
Targeting protein-protein interactions has long been considered as a very difficult if impossible task, but over the past decade, front lines have moved. The number of successful examples is exponentially growing. This review presents a rapid overview of recent advances in this field considering the strengths and weaknesses of the small molecule approaches and alternative strategies such as the selection or design of artificial antibodies, peptides or peptidomimetics. (C) 2016 Academie des sciences. Published by Elsevier Masson SAS.
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