Review
Medicine, General & Internal
Brahm Seymour Coler, Oksana Shynlova, Adam Boros-Rausch, Stephen Lye, Stephen McCartney, Kelycia B. Leimert, Wendy Xu, Sylvain Chemtob, David Olson, Miranda Li, Emily Huebner, Anna Curtin, Alisa Kachikis, Leah Savitsky, Jonathan W. Paul, Roger Smith, Kristina M. Adams Waldorf
Summary: Preterm birth remains a significant cause of infant morbidity and mortality, with limited therapeutic options despite 50 years of research. The global need for better tocolytic agents is particularly urgent, with newer therapeutics targeting inflammatory checkpoints for more effective tocolysis. However, regulatory hurdles and a small market for new PTB therapeutics have hindered pharmaceutical interest in this area.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Anoop Rehal, Zsofia Benko, Catalina De Paco Matallana, Argyro Syngelaki, Deepa Janga, Simona Cicero, Ranjit Akolekar, Mandeep Singh, Petya Chaveeva, Jorge Burgos, Francisca S. Molina, Makrina Savvidou, Maria De la Calle, Nicola Persico, Maria Soledad Quezada Rojas, Ashis Sau, Elena Greco, Neil O'Gorman, Walter Plasencia, Susana Pereira, Jacques C. Jani, Nuria Valino, Maria del Mar Gil, Kate Maclagan, Alan Wright, David Wright, Kypros H. Nicolaides
Summary: Research indicates that vaginal progesterone does not reduce the incidence of spontaneous preterm birth in women with twin pregnancies. Post hoc analysis suggests that progesterone may reduce the risk of spontaneous preterm birth before 32 weeks' gestation in women with a cervical length of <30 mm, but increase the risk for those with a cervical length of >= 30 mm.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Pharmacology & Pharmacy
Hannah C. Zierden, Rachel L. Shapiro, Kevin DeLong, Davell M. Carter, Laura M. Ensign
Summary: Preterm birth is defined as delivery before 37 weeks of gestation, with 15 million infants born prematurely globally each year, increasing the risk of mortality and health challenges. While the only FDA approved therapy for preventing preterm birth in the U.S. has faced recent setbacks, interdisciplinary efforts are underway to develop next generation therapies to prevent preterm birth and save infant lives. This research aims to better identify women at risk for preterm birth, prevent premature labor, and ultimately improve outcomes for newborns.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Ozlem Guzeloglu-Kayisli, Nihan Semerci, Xiaofang Guo, Kellie Larsen, Asli Ozmen, Sefa Arlier, Duygu Mutluay, Chinedu Nwabuobi, Bradley Sipe, Irina Buhimschi, Catalin Buhimschi, Frederick Schatz, Umit A. Kayisli, Charles J. Lockwood
Summary: Depression and posttraumatic stress disorder increase the risk of idiopathic preterm birth, with the involvement of FKBP51 and FKBP5 gene polymorphisms. The binding of FKBP51 to progesterone receptors inhibits their function, leading to labor induction. In mouse models, maternal stress-induced FKBP51 expression and FKBP51-PR binding mediate a mechanism for P4 withdrawal and consequent preterm birth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Gal Cohen, Maya Shavit, Netanella Miller, Rimon Moran, Yael Yagur, Omer Weitzner, Michal Ovadia, Hanoch Schreiber, Gil Shechter-Maor, Tal Biron-Shental
Summary: The study aimed to determine the benefit of 17P treatment in preventing the recurrence of sPTB. The results suggest that 17P treatment can delay preterm delivery and reduce the risk of complications associated with preterm birth for patients with a previous sPTB.
Article
Nutrition & Dietetics
Zhengyuan Wang, Shenglu Zhao, Xueying Cui, Qi Song, Zehuan Shi, Jin Su, Jiajie Zang
Summary: This study aimed to analyze dietary patterns during pregnancy in Shanghai and their impact on preterm birth. It found that the Animal Food Pattern was significantly associated with preterm birth risk, with higher scores indicating a higher risk.
Review
Obstetrics & Gynecology
Amanda Roman, Alexandra Ramirez, Nathan S. Fox
Summary: Twins have a higher risk of preterm birth, and transvaginal ultrasound of the cervical length can predict the occurrence of preterm birth. The use of vaginal progesterone gel can reduce the incidence of preterm birth, and cervical cerclage can decrease both the rate of preterm birth and perinatal mortality.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Obstetrics & Gynecology
George Daskalakis, Dimitrios Zacharakis, Vasilios Pergialiotis, Konstantinos Kalmantis, Mariana Theodora, Charalambos Siristatidis, Panagiotis Antsaklis, Aris Antsaklis, Dimitrios Loutradis
Summary: The combined treatment of cervical pessary and vaginal progesterone has a similar impact on preterm delivery rate before 34 weeks in both low and high-risk women with a mid-trimester short cervix. However, high-risk women have a significantly higher rate of preterm birth before 37 weeks compared to low-risk women.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Rupsa C. Boelig, Corina N. Schoen, Heather Frey, Alexis C. Gimovsky, Edward Springel, Sami Backley, Vincenzo Berghella
Summary: This study aimed to compare vaginal progesterone with 17-hydroxyprogesterone caproate in preventing recurrent preterm birth in singleton pregnancies with previous spontaneous preterm birth. The results showed that vaginal progesterone did not reduce the risk of recurrent preterm birth by 50% compared to 17-OHPC, but it may lead to increased latency to delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Pharmacology & Pharmacy
Doron Kabiri, Yael Hamou, Gali Gordon, Yosef Ezra, Ilan Matok
Summary: A study on 1,048 pregnant women found that vaginal micronized progesterone significantly reduces the risk of preterm birth in women with a shortened cervix in the second trimester; there was no significant difference in the effectiveness of vaginal gel and vaginal capsules containing micronized progesterone for preventing preterm birth.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Melanie H. Jacobson, Cheryl R. Stein, Mengling Liu, Marra G. Ackerman, Jennifer K. Blakemore, Sara E. Long, Graziano Pinna, Raquel Romay-Tallon, Kurunthachalam Kannan, Hongkai Zhu, Leonardo Trasande
Summary: The study investigated the associations between urinary bisphenols and phthalates in early and midpregnancy with serum hormone concentrations and postpartum depression symptoms. The results suggested that certain phthalates were related to lower progesterone levels and increased odds of PPD, indicating a potential influence of endocrine disrupting chemicals on hormonal shifts during pregnancy and PPD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Sara Oday, Maysoon Sharief
Summary: The study found that low salivary progesterone concentrations and measurements of cervical length can effectively predict preterm birth in asymptomatic at-risk women.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
C. Williams, R. Fong, S. Murray, S. J. Stock
Summary: This study found that cesarean birth may increase the risk of preterm birth in subsequent pregnancies, especially when performed at full dilatation.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Medicine, General & Internal
Gian Carlo Di Renzo, Valentina Tosto, Valentina Tsibizova, Eduardo Fonseca
Summary: Gestational age at birth is crucial for perinatal and adulthood outcomes, with preterm birth being a leading cause of infant mortality and morbidity. The global preterm birth rate is around 11%, influenced by complex mechanisms and various known and unknown triggers. Progesterone has been shown to play a key role in preventing preterm birth, with a range of positive effects.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Olivera Iordache, Doru Mihai Anastasiu, Manaswini Kakarla, Ayesha Ali, Felix Bratosin, Radu Neamtu, Catalin Dumitru, Flavius Olaru, Izabella Erdelean, Angelica Gherman, Cecilia Roberta Avram, Lavinia Stelea
Summary: This systematic review examined the relationship between antiphospholipid antibody-associated thrombophilia and adverse pregnancy outcomes, such as preterm birth and impaired fetal development. It found that multiple aPL antibody positivity is associated with a higher risk of preterm birth. Additionally, treatment during pregnancy can significantly reduce the risk of preterm birth.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medical Laboratory Technology
Suzan Boutary, Andoni Echaniz-Laguna, David Adams, Julien Loisel-Duwattez, Michael Schumacher, Charbel Massaad, Liliane Massaad-Massade
Summary: CMT1A, caused by a duplication on chromosome 17p11.2, is the most common form of CMT disease. Current treatments are symptomatic, but there is promising potential in PMP22-targeted small interfering RNA and antisense oligonucleotides.
TRANSLATIONAL RESEARCH
(2021)
Article
Neurosciences
Yousra Laouarem, Abdelmoumen Kassoussi, Amina Zahaf, Tom Hutteau-Hamel, Amine Mellouk, Pierre Bobe, Claudia Mattern, Michael Schumacher, Elisabeth Traiffort
Summary: Hedgehog and androgen signals are coordinated in oligodendrocyte and myelin production, with persistent Hedgehog signaling potentially impeding myelin production, while testosterone has a significant pro-myelinating activity and AR controls neural stem cell commitment. The pathways functionally cooperate in accelerating myelin regeneration, leading to reduced neuroinflammation and functional improvement in demyelinating diseases, with unique effects on cytokines and immune cell populations.
Article
Biochemistry & Molecular Biology
Dalila N. J. Mancino, Maria Luz Leicaj, Analia Lima, Paulina Roig, Rachida Guennoun, Michael Schumacher, Alejandro F. De Nicola, Laura Garay
Summary: Progesterone and its metabolites may play a role in postnatal cerebellar myelination, with higher levels of progesterone observed in P18 and P35 mice, correlating with increased myelination during development.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Neurosciences
Agustina Lara, Ivan Esperante, Maria Meyer, Philippe Liere, Noelia Di Giorgio, Michael Schumacher, Rachida Guennoun, Gisella Gargiulo-Monachelli, Alejandro Federico De Nicola, Maria Claudia Gonzalez Deniselle
Summary: The study on the efficacy of testosterone in the ALS animal model Wobblers mice found that testosterone treatment can alleviate inflammatory responses in the degenerating spinal cord, protect neurons, slow down disease progression, and improve motor performance.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Behavioral Sciences
Regine Sitruk-Ware, Brooke Bonsack, Roberta Brinton, Michael Schumacher, Narender Kumar, Jea-Young Lee, Vanessa Castelli, Sydney Corey, Alexandreya Coats, Nadia Sadanandan, Bella Gonzales-Portillo, Matt Heyck, Alex Shear, Cozene Blaise, Henry Zhang, Michael Sheyner, Julian Garcia-Sanchez, Lisset Navarro, Martine El-Etr, Alejandro F. De Nicola, Cesar Borlongan
Summary: Hormone therapy using progesterone and progestins for CNS disorders shows promise in regenerative medicine, with Nestorone emerging as a potential candidate for diseases such as MS, ALS, SCI, and stroke. Researchers are working to optimize drug regimens and identify suitable patient populations to advance Nestorone to clinical application.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biology
Suzan Boutary, Marie Caillaud, Mevidette El Madani, Jean-Michel Vallat, Julien Loisel-Duwattez, Alice Rouyer, Laurence Richard, Celine Gracia, Giorgia Urbinati, Didier Desmaele, Andoni Echaniz-Laguna, David Adams, Patrick Couvreur, Michael Schumacher, Charbel Massaad, Liliane Massaad-Massade
Summary: The study introduces a treatment for CMT1A using siRNA conjugated to squalene nanoparticles, which resulted in the restoration of pathology and function, providing a potential therapeutic strategy for inherited peripheral neuropathies. This approach demonstrates the concept of precision medicine based on normalizing disease gene expression by using siRNA.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cell Biology
Alejandro F. De Nicola, Maria Meyer, Laura Garay, Maria Sol Kruse, Michael Schumacher, Rachida Guennoun, Maria Claudia Gonzalez Deniselle
Summary: Progesterone plays a crucial role in neuroprotection by improving neuropathology in the Wobbler mouse model, including reducing motoneuron vacuolization, enhancing mitochondrial respiratory complex activity, and decreasing nitric oxide synthase activity. Additionally, progesterone has differential effects on glial cells, such as increasing oligodendrocyte density and decreasing astrogliosis. These changes are associated with reduced expression of anti-inflammatory markers.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Claire-Marie Vacher, Helene Lacaille, Jiaqi J. O'Reilly, Jacquelyn Salzbank, Dana Bakalar, Sonia Sebaoui, Philippe Liere, Cheryl Clarkson-Paredes, Toru Sasaki, Aaron Sathyanesan, Panagiotis Kratimenos, Jacob Ellegood, Jason P. Lerch, Yuka Imamura, Anastas Popratiloff, Kazue Hashimoto-Torii, Vittorio Gallo, Michael Schumacher, Anna A. Penn
Summary: This study reveals that placental ALLO insufficiency alters neurodevelopment in a sex-linked manner, leading to cerebellar white matter abnormalities and autistic-like behavior in male offspring. Gender plays an important role in brain development.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Magalie Frechou, Xiaoyan Zhu, Narender Kumar, Regine Sitruk-Ware, Michael Schumacher, Claudia Mattern, Rachida Guennoun
Summary: The study demonstrates that intranasal administration of Nestorone can effectively promote recovery after stroke and is effective in male mice. Furthermore, the research findings also indicate that neural PR plays a key role in the cerebroprotective effects of Nestorone.
Article
Pharmacology & Pharmacy
Petra Bloms-Funke, Michael Schumacher, Song Liu, Diya Su, Jing Li, Philippe Liere, Rainer Rupprecht, Caroline Nothdurfter, Gregor Bahrenberg, Thomas Christoph, Christopher Habermann, Christa Kneip, Wolfgang Schroeder, Thomas M. Tzschentke, Derek Saunders
Summary: CNP, a chronic neuropathic pain, cannot be effectively prevented or reversed by opioids, necessitating the development of non-opioid options. GRT-X, a novel drug, acts on multiple mechanisms to enhance neuroprotection and neuroregeneration, showing potential as a treatment for CNP.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rainer Rupprecht, Christian H. Wetzel, Mario Dorostkar, Jochen Herms, Nathalie L. Albert, Jens Schwarzbach, Michael Schumacher, Inga D. Neumann
Summary: Efficient treatment of stress-related disorders remains challenging. Neurosteroids show rapid therapeutic effects, but long-term use is limited by tolerance and side effects. Promoting endogenous neurosteroidogenesis via TSPO could provide a new treatment option.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Amina Zahaf, Abdelmoumen Kassoussi, Tom Hutteau-Hamel, Amine Mellouk, Corentine Marie, Lida Zoupi, Foteini Tsouki, Claudia Mattern, Pierre Bobe, Michael Schumacher, Anna Williams, Carlos Parras, Elisabeth Traiffort
Summary: The neuroprotective, anti-inflammatory, and remyelinating properties of androgens have been well documented in demyelinated male mice and men with multiple sclerosis. However, the effects of androgens mediated by the androgen receptor (AR) in females with low androgen levels have been poorly studied. This study reveals a significant expression of AR in microglial cells in demyelinated lesions of female mice and women with multiple sclerosis, while AR expression is almost undetectable in lesions from male animals and men with multiple sclerosis. Additionally, androgens and estrogens act synergistically in female mice, with androgens driving microglial cell response towards regeneration. Transcriptomic comparisons of demyelinated mouse spinal cords show that androgens up-regulate genes related to neuronal function and myelin production, but down-regulate immune system genes in females and lipid catabolism genes in males. These findings highlight the importance of considering male-female differences in therapeutic approaches for demyelinating diseases as androgens are necessary for proper myelin regeneration in females.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Bin Bin Wang, Chao Guo, Sheng Qiao Sun, Xing Nan Zhang, Zhen Li, Wei Jie Li, De Zhi Li, Michael Schumacher, Song Liu
Summary: This study compared the effect of different peripheral nerve injury models on nerve regeneration through animal experiments. It was found that the regeneration speed was faster in the crush injury model, while it was slower in the transection injury model. This provides some reference for the selection of clinical research models.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Neike Fernandez, Anthony Petit, Antoine Pianos, Lena Haddad, Michael Schumacher, Philippe Liere, Rachida Guennoun
Summary: Ischemic stroke is a leading cause of disability and death, and aging is the main nonmodifiable risk factor. Neuroactive steroids play a key role in cerebroprotection. Older mice have decreased capacity to metabolize steroids toward the 5 alpha-reduction pathway compared to younger mice, which may contribute to worsened stroke outcomes.
Article
Neuroimaging
Miao Ling, Binbin Sui, Diya Su, Dezhi Li, Binbin Wang, Hong Wan, Michael Schumacher, Lanxin Ji, Song Liu
Summary: The study investigated the effects of hypoglossal nerve transfer on facial function restoration in patients with facial paralysis. Enhanced activation in motor cortices correlated with improved facial function, suggesting potential targets for adjuvant therapies in the central nervous system.
NEUROIMAGE-CLINICAL
(2021)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
