Article
Clinical Neurology
Yi-Hsien Chen, Wei-Ming Wang, I-Hsun Li, Hui-Han Kao, Chin-Bin Yeh, Li-Ting Kao
Summary: The study provides evidence that MDD is an independent risk factor for developing psoriasis, with a higher risk in males. Further investigation is needed to explore the underlying pathological mechanisms in the psychiatric field.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Xiuwen Li, Huimin Zhang, Xue Han, Lan Guo, Felicia Ceban, Yuhua Liao, Jingman Shi, Wanxin Wang, Yifeng Liu, Weidong Song, Dongjian Zhu, Hongqiong Wang, Lingjiang Li, Beifang Fan, Ciyong Lu, Roger S. McIntyre
Summary: This study explored the association between somatic symptoms and subthreshold depression (SD) and Major Depressive Disorder (MDD), and determined the predictive potential of somatic symptoms in identifying SD and MDD in primary care. The results showed that somatic symptoms were associated with the presence of SD and MDD, and energy-related symptoms had good predictive potential.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Wolfgang Marx, Brenda W. J. H. Penninx, Marco Solmi, Toshi A. Furukawa, Joseph Firth, Andre F. Carvalho, Michael Berk
Summary: MDD is characterized by persistent depressed mood, loss of interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and physical and cognitive symptoms. It is a complex disorder caused by a combination of genetic, environmental, psychological and biological factors. Treatment involves pharmacological therapy with antidepressant medications, psychotherapy or a combination of both, and other biological therapies may be considered for severe and/or treatment-resistant cases.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Clinical Neurology
Dan -Dan Liao, Min Dong, Kai-Rong Ding, Cai-Lan Hou, Wen-Yan Tan, Yun-Fei Ke, Fu-Jun Jia, Shi-Bin Wang
Summary: This study investigated the prevalence rates and patterns of major depressive disorder (MDD) and subthreshold depressive symptoms (SDS) in south China. The results showed a weighted prevalence rate of 2.5% for MDD and 14.7% for SDS. Factors such as gender, age, marital status, lifestyle, and health conditions were found to be positively associated with both MDD and SDS. The study highlights the high prevalence of depression in Guangdong province and calls for attention from policymakers and healthcare professionals.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Alvaro I. Langer, Marcelo A. Crockett, Mariori Bravo-Contreras, Carolina Carrillo-Naipayan, Matias Chaura-Mario, Barbara Gomez-Curumilla, Claudia Henriquez-Pacheco, Rodrigo C. Vergara, Jorge Santander, Zayra Antunez, Tomas Baader
Summary: This study aimed to investigate the prevalence of subthreshold depressive episodes and major depressive episodes in college students during the COVID-19 pandemic in southern Chile, as well as the association between social and economic factors and these depressive symptoms. The results showed that both subthreshold and major depressive symptoms were common in college students, and their associations with social and economic factors varied.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Clinical Neurology
John J. Soderholm, J. Lumikukka Socada, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: The course of illness differs between MDD, BD, and BPD patients. Bipolar depressive patients have an alternating course and the shortest time to first remission. The severity of BPD may predict the duration of remission from depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Jingman Shi, Xue Han, Yuhua Liao, Hao Zhao, Beifang Fan, Huimin Zhang, Kayla M. Teopiz, Weidong Song, Lingjiang Li, Lan Guo, Ciyong Lu, Roger S. McIntyre
Summary: This study examined the association between stressful life events (SLEs) and subthreshold depressive symptoms (SDS) and major depressive disorder (MDD), with a focus on gender effects. The findings showed that individuals who experienced any SLEs were at a higher risk of SDS and MDD. The association between SLEs and SDS was stronger in females, while the association between SLEs and MDD was stronger in males.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Yitan Yao, Qiongyao Yang, Yue Wang, Chuanchuan Chen, Wenhui Wang, Miaomiao Zhang, Yongjie Zhong, Xiaoping Yuan, Yueyue Zhang, Huanzhong Liu, Kai Zhang
Summary: This study is the first large-scale study to examine the age of onset and risk of relapse at the individual level in a Chinese population. It found that adolescent onset is more susceptible to the chronicity of Major Depressive Disorder (MDD).
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Psychiatry
Kexin Huang, Shoumeng Yan, Linquan Bai, Yongliang Jiao, Bingyue Han, Kadierya Momin, Jiangmei Wu, Yong Jia, Li Chen
Summary: Subthreshold depression is a condition that significantly impacts quality of life and increases the risk of developing major depressive disorder. Through a systematic search and analysis of 15 studies, it was found that non-pharmacological interventions have a significant effect in preventing the onset of MDD and improving depressive symptoms. These interventions were particularly effective in general adult populations, during short-term follow-up periods, among pregnant women, and in universal prevention programs. Timely detection and treatment of subthreshold depression is feasible and important in effectively delaying or preventing the onset of major depressive disorder.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Frederikke Hordam Gronemann, Janne Petersen, Sarah Alulis, Kristoffer Jarlov Jensen, Jesper Riise, Mikkel Zollner Ankarfeldt, Espen Jimenez Solem, Nikolaj Bodker, Merete Osler
Summary: This study found that the majority of MDD patients in Denmark initially received treatment with antidepressants or ECT, and often changed medications during the course of treatment. TRD patients were more likely to use SNRIs, and a significant proportion initiated new treatments in the following year.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Roy H. Perlis, Katherine Ognyanova, Alexi Quintana, Jon Green, Mauricio Santillana, Jennifer Lin, James Druckman, David Lazer, Matthew D. Simonson, Matthew A. Baum, Hanyu Chwe
Summary: The study found that social support factors are associated with reduced risk of major depressive symptoms, with religious service attendance and trust in others showing greater protective effects among women than men.
DEPRESSION AND ANXIETY
(2021)
Article
Clinical Neurology
Precious Obehi Eseaton, Abby Uaiye Enosolease, Oyidia Ijioma, Amaka Cynthia Ugoh, Henry Onyeaka, Adeolu Funso Oladunjoye, Gibson Anugwom, Kenneth Osiezagha, Ehizogie Edigin
Summary: This study analyzed the 2018 Nationwide Readmissions Database and found that about one in three SMDD patients were readmitted within 11 months, which poses a significant economic burden and differs from the index admissions. Interventions are needed to reduce readmissions.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Multidisciplinary
Renee J. Thompson, Daphne Y. Liu, Ella Sudit, Matt Boden
Summary: Individuals with current major depressive disorder (MDD) or in remission exhibit low levels of negative and positive emotion differentiation, indicating that diminished emotion differentiation may be a stable characteristic of depressive disorders and a potential target for future prevention efforts.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychiatry
Sarah Tebeka, Christophe Gauld, Raoul Belzeaux, Hugo Peyre, Caroline Dubertret
Summary: This study compared the expression of depressive symptoms between postpartum depression (PPD) and non-perinatal major depression episode (MDE). The results showed that women with PPD were more likely to have appetite disturbance, psychomotor symptoms, and fatigue, while sadness, anhedonia, sleep disturbance, and suicidal ideation were less common. There were no significant differences in the global structure of depressive symptoms, but the centrality of symptoms differed, with sadness being more central for MDE and suicidal ideations being more central for PPD.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychiatry
Sidney Zisook, Beata Planeta, Paul B. Hicks, Peijun Chen, Lori L. Davis, Gerardo Villarreal, Mamta Sapra, Gary R. Johnson, Somaia Mohamed
Summary: The study explores the association between specific types of childhood adversity and clinical features and treatment outcomes in adults with Major Depressive Disorder (MDD). It shows that childhood adversities are linked to demographic characteristics, severity of depression and anxiety, treatment response, and long-term outcomes, emphasizing the importance of considering childhood maltreatment histories in treating individuals with MDD.
GENERAL HOSPITAL PSYCHIATRY
(2022)
Article
Psychiatry
Emily Cantio, Niels Bilenberg, Signe Monrad Norgaard, Iben Have Beck, Soren Moller, Cathriona Cantio, Tina Kold Jensen, Nicoline Bebe Mortensen, Asta Rasmussen, Henrik Boye Thybo Christesen
Summary: This study investigates the association between blood concentrations of serum 25-hydroxyvitamin D at different time points and intelligence quotient score at the age of 7, and explores potential differences in the association based on child sex.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Developmental
Mette Bliddal, Helene Kildegaard, Lotte Rasmussen, Martin Ernst, Poul Jorgen Jennum, Stine Hasling Mogensen, Anton Pottegard, Rikke Wesselhoeft
Summary: This study provides a detailed description of the use of melatonin in Danish children, adolescents, and young adults from 2012 to 2019. The incidence of melatonin use increased during this period, and a significant proportion of users had concurrent psychopathology. Long-term use of melatonin was most common among the youngest age groups.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Anne Mette Skov Sorensen, Rikke Wesselhoft, Jacob Harbo Andersen, Johan Reutfors, Carolyn E. Cesta, Kari Furu, Ingeborg Hartz, Lotte Rasmussen
Summary: The use of ADHD medication among children and adolescents in Scandinavia has been increasing, with Sweden having the highest prevalence. Methylphenidate is the most commonly used drug, and the use of Lisdexamfetamine has been steadily increasing. Males have a higher prevalence of use across different age groups.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Pediatrics
Sofie Rath Mortensen, Jesper Schmidt-Persson, Line Gronholt Olesen, Heidi Klakk Egebaek, Henriette Boye, Niels Bilenberg, Anders Grontved
Summary: This study aimed to investigate the association between parental recreational screen media practices, including time use and level of smartphone addiction, and behavioral difficulties in 7-year-old children. The findings showed no consistent association between parental recreational screen time and behavioral difficulties in their children, but revealed a link between excessive maternal smartphone use and behavioral difficulties in their children.
ACADEMIC PEDIATRICS
(2023)
Editorial Material
Psychology, Developmental
Nina Tejs Jorring, Soren Dalsgaard, Pia Jeppesen, Charlotte Ulrikka Rask, Anne Katrine Pagsberg, Per Hove Thomsen, Niels Bilenberg, Anne Marie Raaberg Christensen
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Mette Bliddal, Lotte Rasmussen, Jacob Harbo Andersen, Peter Bjodstrup Jensen, Anton Pottegard, Trine Munk-Olsen, Helene Kildegaard, Rikke Wesselhoeft
Summary: This cohort study found that Danish youths experienced an increase in rates of psychotropic treatment and psychiatric disorder diagnoses during the COVID-19 pandemic, with the most significant increase observed among those aged 12 to 17 years.
Article
Public, Environmental & Occupational Health
Iben Have Beck, Niels Bilenberg, Soeren Moeller, Flemming Nielsen, Philippe Grandjean, Frederik Damsgaard Hojsager, Thorhallur Ingi Halldorsson, Christel Nielsen, Tina Kold Jensen
Summary: The study found that prenatal and early postnatal exposure to perfluoroalkyl substances (PFAS) may affect intelligence quotient (IQ), especially higher concentrations of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) were associated with lower IQ scores.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Iben Have Beck, Niels Bilenberg, Helle Raun Andersen, Fabio Trecca, Dorthe Bleses, Tina Kold Jensen
Summary: This study investigated the association between prenatal and early postnatal PFAS exposure and delayed language development in Danish children aged 18 to 36 months, and found no significant association between PFAS exposure and language development. The study recommends assessing child serum PFAS at an older age, considering the potential positive effect of breastfeeding on neurodevelopment.
ENVIRONMENTAL HEALTH
(2023)
Article
Psychology, Developmental
Tine Bodil Houmann, Kristine Kaalund-Brok, Lars Clemmensen, Morten Aagaard Petersen, Kerstin Jessica Plessen, Niels Bilenberg, Frank Verhulst, Pia Jeppesen
Summary: This study investigates the early onset of treatment response as a predictor of the long-term symptomatic and functional outcome in children and adolescents with ADHD. The results suggest that the early treatment response can predict the 3-year outcome of symptoms, but not impairment.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Neurosciences
Mikkel Vilmand, Iben Have Beck, Niels Bilenberg, Anna-Maria Andersson, Anders Juul, Greet Schoeters, Henriette Boye, Hanne Frederiksen, Tina Kold Jensen
Summary: This study investigated the association between prenatal and concurrent exposure to phthalates and IQ in 7-year-old children. The results showed that high concentrations of metabolites of di(2-ethylhexyl) phthalate were associated with decreased IQ in children. This suggests that exposure to phthalates may be harmful to child neurodevelopment.
NEUROTOXICOLOGY AND TERATOLOGY
(2023)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Review
Psychology, Developmental
Jette Asmussen, Kirstine Agnete Davidsen, Anne Lise Olsen, Anne Mette Skovgaard, Niels Bilenberg
Summary: Regulatory problems in infancy, including excessive crying, feeding-eating and sleeping, are associated with mental health problems in school ages. This review aims to systematically review longitudinal community-based studies on the combined regulatory problems and mental health outcomes in early childhood. Based on the review of literature published from 2000 to 2020, six papers were included, providing data on two or more regulatory problems among a total of 20,675 children. The review indicates that combined regulatory problems in infancy serve as early markers for mental health problems during early childhood, emphasizing the need for research and preventive interventions targeting early manifestations of childhood dysregulation.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Philippe Grandjean, Alessandra Meddis, Flemming Nielsen, Iben H. Beck, Niels Bilenberg, Carly Goodman, Howard Hu, Christine Till, Esben Budtz-Jorgensen
Summary: By merging data from three birth cohort studies, the study found a statistically significant association between urine-fluoride concentrations and IQ, suggesting the need for protection against fluoride toxicity in pregnant women and children.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Martin Koster Rimvall, Ditte Vassard, Sabrina Mai Nielsen, Rasmus Trap Wolf, Kerstin Jessica Plessen, Niels Bilenberg, Per Hove Thomsen, Mikael Thastum, Simon-Peter Neumer, Louise Berg Puggaard, Mette Maria Agner Pedersen, Anne Katrine Pagsberg, Wendy K. Silverman, Christoph U. Correll, Robin Christensen, Pia Jeppesen
Summary: The study found that Mind My Mind (MMM) cognitive behavioral therapy is effective in treating common emotional and behavioral mental health problems in youth, but not all individuals respond satisfactorily to treatment. The analysis revealed that youths with any mental disorder at baseline, comorbidity, and longer duration of untreated mental health problems showed superior treatment benefits. This highlights the importance of community-based programs like MMM for youth with substantial mental health problems.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Julie Hagstrom, Tine Nielsen, Mikkel E. Sorensen, Kristina Aagaard, Morten Arendt Rasmussen, Julie B. Rosenberg, Parisa Mohammadzadeh, Astrid Sevelsted, Maria Hernandez-Lorca, Birgitte Fagerlund, Jacob Rydkjaer, Anne Katrine Pagsberg, Joan Kaufman, Bjorn H. Ebdrup, Niels Bilenberg, Jens Richardt Mollegaard Jepsen
Summary: The traditional view on psychiatric disorders as categorical and distinct is being challenged by perspectives emphasizing the relevance of dimensional and transdiagnostic assessment. This study describes algorithms for dimensionalizing the psychopathological assessments of children and adolescents and evaluates the construct validity of dimensional ADHD scales.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Wei Ai, William A. Cunningham, Meng-Chuan Lai
Summary: This study aimed to examine the engagement and theoretical drivers of camouflaging behavior in the general population. The findings revealed a similar dimensional structure of camouflaging behavior in the general population compared to previous studies on autism. Social motivational factors, such as social comparison, public self-consciousness, internalized social stigma, and social anxiety, were identified as significant predictors of camouflaging behavior. These findings highlight the shared social coping experience of camouflaging in the general population, including autistic individuals.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Psychiatry
Sheri-Michelle Koopowitz, Karen Thea Mare, Marilyn Lake, Christopher du Plooy, Nadia Hoffman, Kirsten A. Donald, Susan Malcolm-Smith, Lynne Murray, Heather J. Zar, Peter Cooper, Dan J. Stein
Summary: This study investigated the effects of dialogic book-sharing on language development, neurocognitive function, and socio-emotional domains in 3.5-year-old children from low-income South African communities. The results showed no significant differences between the intervention and control groups after 4 months post-intervention.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Psychiatry
Nina Bruinhof, Ela Sehic, Gregory R. Hancock, Maria A. Gartstein, Carolina de Weerth
Summary: The psychometric evaluation of the Baby-PAWS questionnaire in a Dutch sample showed good validity, with a four-factor structure different from the original evaluation in the American sample. American women scored higher on the Baby-PAWS items than Dutch women. These results highlight cross-cultural differences in perinatal mental health and stress the importance of examining instrument structure of context-dependent constructs.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Psychiatry
Noham Wolpe, Aya Vituri, Peter B. Jones, Moni Shahar, Emilio Fernandez-Egea
Summary: This study found that the MAP and EE negative symptom dimensions in patients with treatment-resistant schizophrenia are independent and stable over time, with common causes of secondary negative symptoms clustering in the MAP dimension.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Psychiatry
Cristina Vintro-Alcaraz, Gemma Mestre-Bach, Roser Granero, Monica Gomez-Pena, Laura Moragas, Fernando Fernandez-Aranda, Marc N. Potenza, Susana Jimenez-Murcia
Summary: This study found differences between patients with gambling disorder (GD) with and without self-reported ADHD symptoms in terms of psychopathology, personality, and treatment outcomes. Patients with self-reported ADHD symptoms were more severe in their GD and experienced more severe relapses following treatment. Therefore, more vigilant follow-up and interventions are needed for patients with this comorbidity.
COMPREHENSIVE PSYCHIATRY
(2024)
