期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 3, 页码 1561-1566出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202010780
关键词
allylic compounds; dienes; photocatalysis; radicals; titanium
资金
- LiaoNing Revitalization Talents Program [XLYC1907126]
This study reports a novel photocatalytic strategy for the generation of pi-allyltitanium complexes, allowing for the rapid access to valuable homoallylic alcohols through a three-component allylation reaction with 1,3-butadiene and carbonyls. The exceptional regio- and diastereoselectivity provided by dual photoredox/Ti catalysis is comparable to that of the Cr-catalyzed Nozaki-Hiyama-Kishi allylation reaction.
The addition of pi-allylmetal complexes to carbonyls is the most important route to homoallylic alcohols. This study reports the first photocatalytic generation of pi-allyltitanium complexes by a radical strategy. This novel strategy enables the three-component allylation of carbonyls with 1,3-butadiene, providing rapid access to valuable homoallylic alcohols (over 60 examples). The exceptional regio- and diastereoselectivity provided by dual photoredox/Ti catalysis is comparable to that of the Cr-catalyzed Nozaki-Hiyama-Kishi allylation reaction.
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