期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 22, 页码 5093-5104出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202000716
关键词
Visible-Light-Mediated; S-H bond insertion; cysteine residues; continuous-flow
资金
- National Natural Science Foundation of China [21702103, 21522604, U1463201, 21402240]
- youth in Jiangsu Province Natural Science Fund [BK20150031, BK20130913, BY2014005-03]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province
We describe the application of S-H bond insertion reactions of aryl diazoacetates with cysteine residues that enabled metal-free, S-H functionalization under visible-light conditions. Moreover, this process could be intensified by a continuous-flow photomicroreactor on the acceleration of the reaction (6.5 min residence time). The batch and flow protocols described were applied to obtain a wide range of functionalized cysteine derivatives and cysteine-containing dipeptides, thus providing a straightforward and general platform for their functionalizations in mild conditions.
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