Review
Nanoscience & Nanotechnology
Tom A. Lemaitre, Andrew R. Burgoyne, Maarten Ooms, Tatjana N. Parac-Vogt, Thomas Cardinaels
Summary: This review discusses the incorporation of therapeutic radionuclides into inorganic nanoconstructs as carriers for cancer treatment. Different types of nanomaterials and methods of incorporating radionuclides, and their impact on stability and in vitro and in vivo performances, are discussed.
ACS APPLIED NANO MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Guanyou Lin, Richard A. Revia, Miqin Zhang
Summary: Cancer is a genetic disease caused by the accumulation of gene mutations in a cellular subpopulation, and gene therapy has shown potential to be the ultimate solution for treating cancer. Utilizing nanoscale inorganic carriers for delivering nucleic acids has demonstrated promising results in small-animal models, providing effective and safe treatment for oncological diseases.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Benjamin Neuditschko, Anton A. Legin, Dina Baier, Arno Schintlmeister, Siegfried Reipert, Michael Wagner, Bernhard K. Keppler, Walter Berger, Samuel M. Meier-Menches, Christopher Gerner
Summary: The study reveals that the anticancer agent BOLD-100 interacts with ribosomal proteins, induces ER stress, and modulates GRP78 in cancer cells. Target-profiling experiments and cellular observations provide evidence for these changes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Tais Monteiro Magne, Thamires de Oliveira Vieira, Luciana Magalhaes Rebelo Alencar, Francisco Francine Maia Junior, Sara Gemini-Piperni, Samuel V. Carneiro, Lillian M. U. D. Fechine, Rafael M. Freire, Kirill Golokhvast, Pierangelo Metrangolo, Pierre B. A. Fechine, Ralph Santos-Oliveira
Summary: The review addresses the growing potential use of graphene and its derivatives in various biomedical areas, with particular focus on cancer therapy and diagnosis. The different physicochemical properties of graphene and its derivatives dictate their biocompatibility and toxicity, requiring further research to explain their interactions with biological systems. Despite the increasing studies on the bioavailability and toxicity of graphene and its derivatives, there is still much to be unveiled to develop safe and effective formulations.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ganghao Liang, Tumpa Sadhukhan, Samya Banerjee, Dongsheng Tang, Hanchen Zhang, Minhui Cui, Nicolas Montesdeoca, Johannes Karges, Haihua Xiao
Summary: The development of Pt-IV prodrugs that can be reduced into Pt-II species in the tumor microenvironment has attracted much attention. Selective activation of compounds under irradiation is in high demand for spatial and temporal control over treatment. To overcome the limitation of UV or blue light excitation, the first example of Pt-IV prodrug nanoparticles that can be reduced with deeply penetrating ultrasound radiation is reported, enabling the treatment of deep-seated or large tumors. These nanoparticles selectively accumulate in a mouse colon carcinoma tumor and can eradicate the tumor upon exposure to ultrasound radiation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Astha Sharma, Yan He, Baboucarr Lowe, Arwa Salam, Tariq A. Altalhi, Qingsong Ye, Tushar Kumeria
Summary: Biomaterials have brought tissue engineering and regeneration into a new era with the development of advanced composites. Inorganic particle/polymer composites with unique structural and biochemical properties have gained significant attention. This review discusses recent progress in the use of inorganic particle/polymer composites for tissue engineering and regenerative medicine, highlighting the advantages over organic particle-based composites. The review also explores different types of inorganic particles used in inorganic particle/polymer composites and touches on other new types of inorganic material-based polymer composites for tissue engineering applications.
BIOACTIVE MATERIALS
(2023)
Review
Multidisciplinary Sciences
Saniha Ajith, Fares Almomani, Abdelbary Elhissi, Ghaleb A. Husseini
Summary: In the past decade, novel strategies using nanocarriers have made breakthroughs in the treatment of cancer. These nanocarriers deliver drugs directly to cancer cells while minimizing side effects on healthy tissues. Studies have shown that using drugs encapsulated in nanocarriers is a safer and more effective alternative.
Review
Chemistry, Multidisciplinary
Johannes Karges
Summary: Platinum(II) complexes are widely used in chemotherapy, but are associated with severe side effects and poor tumor selectivity. To address this issue, platinum(IV) molecular prodrugs and nanoparticle formulations that can be activated into therapeutically active analogs through specific triggers have been explored. This article critically reviews the mechanisms for activating platinum(IV) prodrugs using chemical and photophysical triggers.
Article
Nanoscience & Nanotechnology
Jianxian Ge, Lei Chen, Baoxing Huang, Yun Gao, Dandan Zhou, Yi Zhou, Can Chen, Ling Wen, Qing Li, Jianfeng Zeng, Zhiyuan Zhong, Mingyuan Gao
Summary: This study demonstrates the universality of a simple and efficient radiolabeling method, LAGMERAL, for constructing radioactive nanoprobes. The method utilizes a diphosphonate-polyethylene glycol (DP-PEG) group on the surface of inorganic nanoparticles for efficient radiolabeling. The resulting nanoprobes exhibit high radiolabeling stability and biocompatibility, making them promising for sensitive tumor diagnosis. This research highlights the importance and potential of LAGMERAL in nuclear medicine imaging.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Inorganic & Nuclear
Johannes Karges, Kai Xiong, Olivier Blacque, Hui Chao, Gilles Gasser
Summary: The study found that copper (II) polypyridine complexes have significant cytotoxic effects on human adenocarcinomic alveolar basal epithelial cells, and are equally effective against cisplatin-resistant cells, potentially serving as a treatment option for drug-resistant tumors.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Junjun Liu, Lin Yang, Ping Qin, Shiqing Zhang, Ken Kin Lam Yung, Zhifeng Huang
Summary: Inorganic nanoparticles are a versatile platform for biomedical applications, particularly in the study and application of chiral effects. Recent research focuses on characterizing 3D stereochirality, bionic fabrication of hierarchical chirality, studying optical activities, and experimental demonstration in biomedical applications. These studies pave the way for fully understanding and utilizing chiral effects in the design and fabrication of inorganic chiral nanoparticles for practical problem-solving in environment and public health.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Qi Sun, Yi Wang, Qiuxia Fu, Ai Ouyang, Shanshan Liu, Zhongyuan Wang, Zijie Su, Jiaxing Song, Qianling Zhang, Pingyu Zhang, Desheng Lu
Summary: The sulfur-coordinated organoiridium(III) complexes pbtIrSS and ppyIrSS were found to inhibit breast cancer tumorigenesis and metastasis by targeting Wnt/beta-catenin signaling for the first time. Treatment with these complexes can decrease the expression of Wnt target genes, suppress cell migration and invasion, and regulate the stemness properties of breast cancer cells. These complexes have the potential to be developed as novel breast cancer therapeutic agents with potent anti-tumor and anti-metastasis effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biotechnology & Applied Microbiology
Fumei He, Jinxiu Cao, Junyang Qi, Zeqi Liu, Gan Liu, Wenbin Deng
Summary: Inorganic nanomaterials have unique physical and chemical properties that can optimize the therapeutic effects of stem cell transplantation and influence stem cell differentiation. They can be used as vectors to transport substances that interfere with the fate of stem cells, due to their huge specific surface area and modifiability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Elena Giusto, Ludmila Zarska, Darren Fergal Beirne, Arianna Rossi, Giada Bassi, Andrea Ruffini, Monica Montesi, Diego Montagner, Vaclav Ranc, Silvia Panseri
Summary: This study developed a graphene oxide-based nanocarrier to overcome the limitations of platinum-based chemotherapeutics. The results demonstrated that this nanoplatform has good anti-tumor effects in various cancer cells and potential for inhibiting cell migration.
Review
Chemistry, Medicinal
Yuan Fan, Shaobo Ou-yang, Dong Zhou, Junchao Wei, Lan Liao
Summary: Chirality is widespread in nature and plays a crucial role in maintaining physiological processes. Chiral inorganic nanomaterials with intense optical activity have gained much attention in recent years for their remarkable properties. The preparation and chirality origin of chiral nanomaterials have been extensively studied, and emerging biological applications have also been investigated.
Article
Biochemistry & Molecular Biology
Maria J. S. A. Silva, Robin Vinck, Youchao Wang, Bruno Saubamea, Mickael Tharaud, Elena Dominguez-Jurado, Johannes Karges, Pedro M. P. Gois, Gilles Gasser
Summary: An increasing number of novel Ru(II) polypyridyl complexes have been successfully applied as photosensitizers (PSs) for photodynamic therapy (PDT). Classical maleimide and versatile NHS-activated acrylamide strategies were employed to conjugate a promising Ru(II) polypyridyl complex to the N-terminally Cys-modified Bombesin (BBN) targeting unit. Although lacking in tumoral selectivity, the new bioconjugates showed high phototoxic activity and decreased toxicity in the absence of light irradiation, making them potentially useful for advanced cancer treatment.
Article
Chemistry, Inorganic & Nuclear
Mariano Soba, Gonzalo Scalese, Federico Casuriaga, Nicolas Perez, Nicolas Veiga, Gustavo A. Echeverria, Oscar E. Piro, Ricardo Faccio, Leticia Perez-Diaz, Gilles Gasser, Ignacio Machado, Dinorah Gambino
Summary: In this study, multifunctional Re(I) tricarbonyl compounds were designed as potential antichagasic drugs. These compounds showed activity against T. cruzi and demonstrated good selectivity towards the parasite compared to mammalian cells. The mechanism of action and physicochemical properties of these compounds were also investigated, showing promising potential for further drug development.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Organic
Capucine Mahe, Olivier Blacque, Gilles Gasser, Vincent Gandon, Kevin Cariou
Summary: The first synthesis of various N-metallocenyl ynamides has been achieved, along with the development of two strategies for the oxidative cyclization of N-ferrocenyl ynamide into ansa[3]-ferrocenylamide. The mechanism for the iodine(III)-triggered transformation has been investigated using DFT calculations, revealing a concerted iodination deprotonation step.
Article
Chemistry, Physical
Elie Geagea, Ali Hamadeh, Judicael Jeannoutot, Frank Palmino, Nicolas Breault, Alain Rochefort, Samar Hajjar-Garreau, Carmelo Pirri, Christophe M. Thomas, Frederic Cherioux
Summary: We demonstrate efficient dissociation of the strong N-2 bond at low pressure and ambient temperature on a Si(111)-7x7 surface. Experimental investigation and density functional theory results suggest that electron transfer from the Si(111)-7x7 surface to the pi*-antibonding orbitals of N-2, facilitated by relatively low thermal energy collisions, significantly weakens the N-2 bond, leading to the formation of a Si3N interface on the surface.
Article
Biochemistry & Molecular Biology
Youchao Wang, Patrick S. S. Felder, Pierre Mesdom, Olivier Blacque, Thomas L. L. Mindt, Kevin Cariou, Gilles Gasser
Summary: The synthesis and characterization of a ruthenium-rhenium binuclear complex, combining the photophysical properties of a rhenium(I) tricarbonyl complex and a ruthenium(II) polypyridyl complex, is presented in this study for its potential use as a photosensitizer in anticancer photodynamic therapy. One of the complexes synthesized, which localized in mitochondria, showed selectivity towards human lung carcinoma A549 and human colon colorectal adenocarcinoma HT29 cells, with interesting photo-index (PI) values of 135.1 and 256.4, respectively, compared to noncancerous retinal pigment epithelium RPE1 cells (22.4).
Article
Biochemistry & Molecular Biology
Germain Niogret, Alix Bouvier-Muller, Chiara Figazzolo, Jack M. Joyce, Frederic Bonhomme, Patrick England, Olena Mayboroda, Riccardo Pellarin, Gilles Gasser, James H. R. Tucker, Julian A. Tanner, G. Paul Savage, Marcel Hollenstein
Summary: Chemical modification of aptamers is important for improving their performance and stability. By combining enzymatic synthesis and nucleotides with bioisosteres, the synthetic burden of post-SELEX modification can be reduced and additional sequences with maintained binding but reduced specificity can be identified.
Review
Chemistry, Multidisciplinary
Yiyi Zhang, Bich-Thuy Doan, Gilles Gasser
Summary: This review systematically summarizes the effects of metal-based photosensitizers (PSs) on different types of regulated cell death (RCD), including ferroptosis, immunogenic cell death (ICD), and pyroptosis. The characteristics and mechanisms of each RCD are explained, and commonalities between different metal-based PSs inducing the same RCD are emphasized. Future perspectives on metal-based PSs inducing novel forms of RCD are also discussed.
Article
Chemistry, Multidisciplinary
Lisa Gourdon-Grunewaldt, Marija Bakija, Lara Wild, Berislav Peric, Gilles Gasser, Srecko I. Kirin, Kevin Cariou
Summary: In order to achieve bioorthogonal intracellular catalysis, a library of platinum(II) complexes was synthesized. The non-toxicity of these complexes to living cells was demonstrated and their catalytic activity was evaluated. None of the platinum complexes showed any catalytic activity for the targeted reaction, but it was found that the silver salt AgSbF6 commonly used to 'activate' metal catalysts was a very efficient catalyst for the studied intramolecular cyclization reaction.
HELVETICA CHIMICA ACTA
(2023)
Article
Chemistry, Inorganic & Nuclear
Lucy E. Enslin, Kallol Purkait, Maria Dalla Pozza, Bruno Saubamea, Pierre Mesdom, Hendrik G. Visser, Gilles Gasser, Marietjie Schutte-Smith
Summary: This report presents highly cytotoxic Re(I) carbonyl complexes with low nanomolar activity against prostate cancer cells, highlighting the potential of using rhenium in cancer treatment. Eight aqua complexes with a general formula of fac-[Re(CO)(3)(N,N'-bid)(H2O)][NO3] were synthesized and characterized. The cytotoxicity of these complexes was evaluated on prostate cancer cells, with three complexes showing very low cytotoxic activity and selectivity over normal cells. Further experiments revealed the mitochondrial and nuclear localization of the most selective complexes, as well as their impact on mitochondrial dysfunction and ATP production in cancer cells.
INORGANIC CHEMISTRY
(2023)
Editorial Material
Chemistry, Multidisciplinary
Gloria Vigueras, Gilles Gasser
Summary: Pharmacologically inactive prodrugs activated by near-infrared light have potential clinical applications. Platinum-based photo-oxidants have been shown to eliminate tumors in mice through a new mode of action.
Article
Chemistry, Physical
Bo Jiang, Christophe M. M. Thomas
Summary: To address environmental problems and promote sustainable plastics production, there is growing interest in developing selective methods to convert renewable feedstocks into monomers suitable for polymers. In this study, a one-pot catalytic synthesis of polycarbonates from renewable resources is presented. This approach utilizes a commercially available magnesium catalyst to couple diethyl carbonate with a camphor-based diol, providing access to a new library of unique polycarbonates. Furthermore, chemical recycling of these polycarbonates can be initiated through magnesium-catalyzed methanolysis.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Sara Benetti, Maria Dalla Pozza, Lorenzo Biancalana, Stefano Zacchini, Gilles Gasser, Fabio Marchetti
Summary: Novel diiron vinyliminium complexes were synthesized and characterized by various spectroscopic techniques. Their solubility in D2O, Log Pow coefficients, and stability in aqueous media were determined. The antiproliferative activity of these complexes on cancer cell lines was evaluated and their mechanism of action was investigated by assessing their influence on mitochondrial respiration.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Yandong Ma, Zhihua Zhang, Fan Sun, Pierre Mesdom, Xin Ji, Pierre Burckel, Gilles Gasser, Min-Hui Li
Summary: Polymer micelles/vesicles made of a red-light-responsive block copolymer are developed as a model system for anticancer phototherapy. The system can release Ru complexes and generate ROS under red-light irradiation, leading to high cytotoxicity against cancer cells.
Article
Chemistry, Multidisciplinary
Youchao Wang, Pierre Burckel, Kallol Purkait, Bruno Saubamea, Pierre Burckel, Philippe Arnoux, Celine Frochot, Kevin Cariou, Thibaud Rossel, Gilles Gasser
Summary: Photodynamic therapy (PDT) is a medical technique that uses non-toxic molecules called photosensitizers (PSs) for cancer treatment. This study introduces novel ruthenium and osmium polypyridyl complexes that can target carbonic anhydrases (CAs), which are overexpressed in cancer cells. These complexes accumulate in cancer cells and effectively kill them when irradiated with light. This research proposes a strategy to improve the selectivity of PDT.
Article
Chemistry, Multidisciplinary
Youchao Wang, Pierre Burckel, Kallol Purkait, Bruno Saubamea, Pierre Burckel, Philippe Arnoux, Celine Frochot, Kevin Cariou, Thibaud Rossel, Gilles Gasser
Summary: Photodynamic therapy is a medical technique that uses non-toxic molecules to selectively kill cancer cells when irradiated with light. This study presents novel complexes that target carbonic anhydrases, improving the selectivity of photodynamic therapy for cancer treatment.
