期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 52, 期 10, 页码 1055-1062出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmaa098
关键词
reactive oxygen species; osteoclast resorption; osteoblast formation; signaling pathway; ROS scavenger
资金
- National Natural Science Foundation of China [81873991, 81771885, 81672238, 81472077, 81572183, 91849114, 81472105]
- Young Medical Talents of Jiangsu Province [QNRC2016751]
- Natural Science Foundation of Jiangsu Province [BK20180001]
- Basic Applied Research Program of Suzhou City [SYS2018032, KJXW2017002, KJXW2017009]
Accumulating evidence indicates that intracellular reactive oxygen species (ROS) production is highly involved in bone homeostasis by intervening osteoclast or osteoblast differentiation. Interestingly, ROS that are known as oxidizing agents exert dose-dependent biphasic properties in bone remodeling, including preventing osteoblast activity but accelerating osteoclast resorption. ROS mainly composed of superoxide anion radical, hydroxyl radical, nitric oxide, and two-electron reduction product hydrogen peroxide, which are important components to regulate bone cell metabolism and function in mammal skeleton. These free radicals can be partly produced in bone and boosted in an inflammation state. Although numerous researches have emphasized the impacts of ROS on bone cell biology and verified the mechanism of ROS signaling cascades, the recapitulatory commentary is necessary. In this review article, we particularly focus on the regulation of the intracellular ROS and its potential mechanism impacting on cell-signaling transduction in osteoclast and osteoblast differentiation for preferable understanding the pathogenesis and searching for novel therapeutic protocols for human bone diseases.
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