期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 38, 页码 42586-42594出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c13518
关键词
microfluidics; probiotics; microcapsule; intestinal barrier; gastrointestinal disease
资金
- National Natural Science Foundation of China [61927805, 51522302]
- NSAF Foundation of China [U1530260]
- Natural Science Foundation of Jiangsu [BE2018707]
- Scientific Research Foundation of Southeast University
- Joint Fund of Basic and Applied Basic Research Fund of Guangdong Province [2019A1515110925, 2019A1515111155]
- China Postdoctoral Science Foundation [2019M663108, 2019M653061]
- Science, Technology and Innovation Commission of Shenzhen Municipality [JCYJ20190808120405672, JCYJ20170817171930009]
- Scientific Research Foundation of the Graduate School of Southeast University
- Fudan University [JIH1340032, JIH1340038]
- Zhongshan-Xuhui Hospital
Designing strategies to utilize the synergistic effect of probiotics and prebiotics is a promising way in treating metabolic-related diseases. Here, inspired by the mutually promotable but mutually incompatible characteristics of Yin and Yang, dual-core microcapsules that encapsulate Lactobacillus and Bacillus subtilis into separate compartments were presented through electrostatically driven microfluidics. The microcapsules showed acid resistance and preserved probiotic activity. They also fostered the proliferation of probiotics while creating an anaerobic environment and promoted lactic acid fermentation without affecting each other. It has been demonstrated that the microcapsules could reduce inflammation, improve fat metabolism, and restore intestinal barrier functions, thus contributing to the treatment of metabolic syndrome in vivo. These features make the dual-core microcapsules an ideal candidate for treating metabolic syndrome and related diseases.
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