Article
Chemistry, Multidisciplinary
Saloni Bhatia, Padmini Gokhale, Teesta Katte, Shreeshanthi Acharya, Avinash Arvind Rasalkar, Soumya Vidapanakal, Ram Manas, Sampath Chinnam, Prathibha Narayanan, Ashok Kumar Shettihalli, Vijayakumar Kadappa, Divijendra Natha Reddy Sirigiri
Summary: This study analyzed the expression status of genes related to the infectivity and propagation of SARS-CoV-2 to assess the susceptibility of certain cancer patients to COVID-19 infection and subsequent complications. The findings suggest that patients with specific types of cancer are more at risk for COVID-19, and the genes responsible for severe COVID-19 are highly expressed in various cancer types.
Article
Medical Laboratory Technology
Maria Westerhoff, Dan Jones, Steven M. Hrycaj, May P. Chan, Liron Pantanowitz, Huolin Tu, Karen Choi, Joel Greenson, Laura Lamps
Summary: This study evaluated the histopathology and in situ hybridization for SARS-CoV-2 in gastrointestinal samples from COVID-19 patients. The findings suggest a varied range of gastrointestinal manifestations in patients with COVID-19, but no distinct histologic findings were identified.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Charlotte Steenblock, Stefanie Richter, Ilona Berger, Marko Barovic, Janine Schmid, Undine Schubert, Natalia Jarzebska, Anne von Maessenhausen, Andreas Linkermann, Annette Schuermann, Jessica Pablik, Thomas Dienemann, Katja Evert, Roman N. Rodionov, Natalia Y. Semenova, Vsevolod A. Zinserling, Raul R. Gainetdinov, Gustavo Baretton, Dirk Lindemann, Michele Solimena, Barbara Ludwig, Stefan R. Bornstein
Summary: This study comprehensively analyzed pancreatic tissues from COVID-19 patients and found detectable SARS-CoV-2 viral infiltration in beta-cells, potentially contributing to metabolic dysregulation. Even in the absence of overt new-onset diabetes, viral infection of pancreatic beta-cells may lead to varying degrees of metabolic abnormalities.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu
Summary: The study found that the S protein of SARS-CoV-2 may lead to dysfunction and death of pericytes, potentially contributing to microvascular injury, and it activates the ERK1/2 pathway through the CD147 receptor, which could play a role in microvascular damage.
Article
Multidisciplinary Sciences
Sebastian Cremer, Lisa Pilgram, Alexander Berkowitsch, Melanie Stecher, Siegbert Rieg, Mariana Shumliakivska, Denisa Bojkova, Julian Uwe Gabriel Wagner, Galip Servet Aslan, Christoph Spinner, Guillermo Luxan, Frank Hanses, Sebastian Dolff, Christiane Piepel, Clemens Ruppert, Andreas Guenther, Maria Madeleine Ruethrich, Joerg Janne Vehreschild, Kai Wille, Martina Haselberger, Hanno Heuzeroth, Arne Hansen, Thomas Eschenhagen, Jindrich Cinatl, Sandra Ciesek, Stefanie Dimmeler, Stefan Borgmann, Andreas Zeiher
Summary: Patients with cardiovascular comorbidities who take angiotensin II receptor blockers have lower mortality rates in COVID-19 compared to those who do not take these medications. This effect is particularly significant in patients who present early in the course of the disease. Additionally, these patients on ARBs also show lower levels of inflammatory markers and reduced frequency of reaching mortality-predicting thresholds.
Article
Immunology
Zhenglin Chang, Lingyue An, Min Lei, Zhenfeng Song, Jian Deng, Ruizheng Tang, Zhangkai J. J. Cheng, Wenqi Wu, Baoqing Sun
Summary: This study found that COVID-19 is causally associated with an increased risk of lower urinary tract calculi and sexual dysfunction. However, it may have a slight protective effect on urinary tract infections and bladder cancer. Molecular pathway analysis suggests that the inflammatory-immune response module may mediate the connection between COVID-19 and its associated genitourinary disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sean T. Koester, Naisi Li, Daniel M. Lachance, Norma M. Morella, Neelendu Dey
Summary: Patients with gastrointestinal symptoms of COVID-19 tend to have worse prognosis. The gene Ace2, expressed in the gut and encoding the host protein targeted by SARS-CoV-2, may play a role in mitigating COVID-19 severity. Research suggests that the microbiome could potentially modulate Ace2 expression, impacting COVID-19 infection risk and disease severity.
Article
Cell Biology
Juan A. Perez-Bermejo, Serah Kang, Sarah J. Rockwood, Camille R. Simoneau, David A. Joy, Ana C. Silva, Gokul N. Ramadoss, Will R. Flanigan, Parinaz Fozouni, Huihui Li, Pei-Yi Chen, Ken Nakamura, Jeffrey D. Whitman, Paul J. Hanson, Bruce M. McManus, Melanie Ott, Bruce R. Conklin, Todd C. McDevitt
Summary: This study found that heart cells of COVID-19 patients exposed to SARS-CoV-2 may suffer significant damage such as myofibrillar fragmentation and nuclear disruption, providing insights for potential therapeutic discovery.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biology
Julien Brechbuhl, Ana Catarina Lopes, Dean Wood, Sofiane Bouteiller, Aurelie de Valliere, Chantal Verdumo, Marie-Christine Broillet
Summary: The COVID-19 pandemic has sparked a global scientific effort to study the SARS-CoV-2 virus, with a focus on infection mechanisms and symptoms. Research shows that the virus directly affects the human chemosensory systems, leading to anosmia and ageusia. Mouse experiments suggest that the virus targets basal and sensory cells, with viral entry sites appearing age-dependently.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Petter Brodin
Summary: The severity of COVID-19 varies by sex and age, and is linked to comorbidities. Differences in immune reactions may go some way to explain this.
Review
Biochemistry & Molecular Biology
Hyung Muk Choi, Soo Youn Moon, Hyung In Yang, Kyoung Soo Kim
Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic. Severe patients lack definitive treatment, only symptomatic drugs are used based on clinician experience. Basic medical researchers are exploring the pathogenesis of COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Mohammadarian Akbari, Mohammad Taheri, Golbarg Mehrpoor, Solat Eslami, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Noormohammad Arefian
Summary: The contribution of the renin-angiotensinogen system in the risk of COVID-19 and related complications has been assessed, but the results are inconsistent. This study examined ACE1 and ACE2 levels in COVID-19 patients and healthy controls, as well as genotyped two polymorphisms in the ACE1 gene. The findings suggest that ACE1 polymorphisms may affect the risk of COVID-19 and ACE expression.
VASCULAR PHARMACOLOGY
(2022)
Article
Cell Biology
Rocio Diaz Escarcega, Pedram Honarpisheh, Gabriela Delevati Colpo, Hilda W. Ahnstedt, Lucy Couture, Shivanki Juneja, Glenda Torres, Guadalupe J. Ortiz, James Sollome, Natalie Tabor, Bhanu P. Ganesh, H. Alex Choi, Fudong Liu, Louise D. McCullough, Andrey S. Tsvetkov
Summary: The study finds sex differences in metabolism and sexual dimorphism in the correlations between clinical parameters and metabolic profiles in severe COVID-19 patients, providing important knowledge for the development of sex-associated biomarkers and druggable targets for COVID-19 patients.
CELL DEATH & DISEASE
(2022)
Review
Andrology
Farzam Sheikhzadeh Hesari, Seyedeh Shaghayegh Hosseinzadeh, Mohammad Ali Asl Monadi Sardroud
Summary: Research indicates that the male reproductive system may be susceptible to SARS-CoV-2 infection, highlighting the importance of further examination and tests to address related complications and fertility issues.
Review
Biochemistry & Molecular Biology
Raziyeh Najafloo, Jila Majidi, Alimohamad Asghari, Mina Aleemardani, Seyed Kamran Kamrava, Sara Simorgh, Amelia Seifalian, Zohreh Bagher, Alexander M. Seifalian
Summary: The mechanism of anosmia in COVID-19 patients is multifaceted, involving factors such as inflammation, cell apoptosis, and odor transmission. Novel treatment strategies for long-term anosmia involve smart drug delivery, tissue engineering, and cell therapy to support efficient recovery of the olfactory system.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Otorhinolaryngology
Mengqing Zhang, Chao Li, Fang Zhang, Xiaoxiao Han, Qinglu Yang, Tuo Lin, Huichang Zhou, Min Tang, Jungui Zhou, Hongling Shi, Yanping Hui, Mingfeng Xiong, Ling Pang, Baolan Wang, Zhen Feng, Zhanfei Li, Changbing Cao, Xiao Lu, Yuanyuan Ding, Shukun Shen, Zhengyue Xu, Fan Yu, Chen Chen, Ling Meng, Guiqing Liao, Jinxin Zhang, Ayodele Sasegbon, Zulin Dou
Summary: The study found a high prevalence of dysphagia among older individuals and patients with stroke, head and neck cancers, or neurodegenerative diseases in China. The prevalence of dysphagia increases steadily with age and comorbid disease. Individuals with dysphagia are more likely to suffer from malnutrition.
Article
Cell Biology
Farong Ou, Yihuan Huang, Jiadong Sun, Kai Su, Yiqing He, Rongsheng Zeng, Dongxiao Tang, Guiqing Liao
Summary: Yohimbine can suppress TMJOA-induced chondrocyte inflammation, and the inhibition of the NF-kappa B pathway contributes to this effect.
Article
Medicine, Research & Experimental
Shanwei Shi, Huigen Luo, Lihong Wang, Hua Li, Yujie Liang, Juan Xia, Zhi Wang, Bin Cheng, Linfeng Huang, Guiqing Liao, Baoshan Xu
Summary: The study demonstrated that OSCC tumors with partial loss of 45S rDNA copy number were sensitive to CX5461 and the combination of CX5461 and INK128. The synergistic effects of the cotreatment induced apoptosis, inhibited cell growth, and prolonged the survival time of tumor-bearing mice. INK128 also enhanced the antitumor activity of CX5461 by compromising the NHEJ-DNA repair pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiangqi Liu, Qunxing Li, Ying Zhou, Xinlin He, Juan Fang, Huanzi Lu, Xi Wang, Dikan Wang, Da Ma, Bin Cheng, Guiqing Liao, Zhi Wang
Summary: The study revealed that T-cell expression of TIGIT is elevated in patients with oral squamous cell carcinoma (OSCC) and is associated with T stage and nodal invasion. Additionally, TIGIT-expressing T cells display a dysfunctional and inhibitory phenotype, while TIGIT blockade enhances proliferation ability and cytokine production in CD4(+) and CD8(+) T cells.
Article
Cell Biology
Mo Liu, Qingwen Liu, Song Fan, Feng Su, Chun Jiang, Guanming Cai, Youyuan Wang, Guiqing Liao, Xinyuan Lei, Weixiong Chen, Junming Bi, Weiqi Cheng, LuoDan Zhao, Yi Ruan, Jinsong Li
Summary: Abnormal expression of long-noncoding RNA, LTSCCAT, is involved in the tumorigenesis and progression of tongue squamous cell carcinoma (TSCC). LTSCCAT promotes invasion and metastasis of TSCC by acting as a competitive endogenous RNA for miR-103a-2-5p to regulate metastasis-related genes.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Pensiri Saenthaveesuk, Le Yang, Bin Zeng, Meng Xu, Simon Young, Guiqing Liao, Yujie Liang
Summary: A nomogram incorporating multiparametric MRI was developed and validated to predict occult nodal metastasis risk in patients with squamous cell carcinoma of lateral tongue, demonstrating good predictive accuracy and calibration.
Article
Oncology
Yudong Xiao, Tao Wang, Wei Deng, Le Yang, Bin Zeng, Xiaomei Lao, Sien Zhang, Xiangqi Liu, Daiqiao Ouyang, Guiqing Liao, Yujie Liang
Summary: This study found that FCR is a potential acoustic marker for detecting disease and speech function related to oral tongue cancers. There was a strong correlation between pre-operative FCR and SHI scores, with FCR increasing significantly with higher T classification especially in women. Longitudinally, the effects of T classification, extent of resection, and their interaction with time on FCR were all significant.
Article
Polymer Science
Zhengshi Li, Huimin Lin, Shanwei Shi, Kai Su, Guangsen Zheng, Siyong Gao, Xuan Zeng, Honglong Ning, Meng Yu, Xiang Li, Guiqing Liao
Summary: Bone healing is a complex process that requires the participation of cells and bioactive factors. SDF-1 alpha and Mg2+ are significant bioactive factors for cell recruitment and osteogenesis during bone regeneration. A bifunctional hydrogel containing a sequential delivery system is fabricated to improve osteogenesis. The XPMS hydrogel, loaded with SDF-1 alpha and Mg2+, provides a novel strategy for repairing bone defects.
Article
Chemistry, Physical
Di Wu, Lu Zhao, Bingdong Sui, Lingping Tan, Lu Lu, Xueli Mao, Guiqing Liao, Songtao Shi, Yang Cao, Xiaobao Yang, Xiaoxing Kou
Summary: This study establishes a function-oriented mathematical model to evaluate and predict the regenerative capacity and stemness of MSCs, and validates the predictive power of the model.
Article
Oncology
Wei Deng, Guiyi Zhao, Zhengshi Li, Le Yang, Yudong Xiao, Sien Zhang, Kaixin Guo, Chunqing Xie, Yujie Liang, Guiqing Liao
Summary: This study investigated the recovery process of swallowing function and identified swallowing pattern in patients undergoing total glossectomy. The results showed that patients who underwent total glossectomy had severely impaired swallowing function and safety. Abnormalities in water swallow test outcomes and videofluoroscopy swallowing study were observed in these patients.
Article
Oncology
Kan Li, Jianbin Gong, Qiuhan Zheng, Le Yang, Xueying Mei, Jianghai Chen, Guiqing Liao, Yujie Liang
Summary: This study found that multiple primary oral cancers (MP-OCs) and primary oral cancers (P-OCs) have different molecular characteristics. MP-OCs have worse prognosis, more somatic mutations, more complicated mutation signatures, and higher tumor mutational burden and mutant-allele tumor heterogeneity. In addition, MP-OCs and P-OCs also differ in the pattern of copy number variation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Huiyi Liang, Yibo Du, Chenxu Zhu, Zhaoqiang Zhang, Guiqing Liao, Lixin Liu, Yongming Chen
Summary: Cancer metastasis that is resistant to conventional therapies has become a major cause of patient death. Recent reports indicate that the neutrophil extracellular trap (NET) is closely associated with cancer distant metastases, and the cell-free DNA of NETs has been identified as the ligand of the transmembrane protein CCDC25 of cancer cells, acting as a chemokine to induce cancer cell migration to distant organs. A strategy using poly(aspartic acid) based-cationic materials is presented to interfere with the interaction between NET-DNA and CCDC25, inhibiting NET-DNA-mediated cancer cell chemotaxis and migration. Nanoparticulate poly(aspartic acid) derivatives efficiently reduce hepatic NET-DNA infiltration and suppress cancer metastases in mice and human metastatic models without toxicity to organs.
Article
Oncology
Shuqin Wang, Sien Zhang, Zhi Lin, Jingxin Ma, Lijun Zhu, Guiqing Liao
Summary: In this study, an apoptosis-related gene (ARG) prediction model was established to predict the survival rate of oral squamous cell carcinoma (OSCC) patients. The model showed good prognostic ability and a nomogram was built to forecast the survival probability of OSCC patients. GO and KEGG analyses revealed multiple molecular biological processes and signaling pathways associated with this prognostic model in OSCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell & Tissue Engineering
W. Liao, J. Sun, Y. Wang, Y. He, K. Su, Y. Lu, G. Liao, Y. Sun
Summary: This study confirms that histone deacetylase (HDAC) inhibitors can improve the inhibition of chondrogenesis caused by arthritis, and it identifies the inhibition of the IL-6/MMP13 pathway as a contributing factor to this process.
BONE & JOINT RESEARCH
(2022)
Review
Medicine, General & Internal
Qiuhan Zheng, Le Yang, Bin Zeng, Jiahao Li, Kaixin Guo, Yujie Liang, Guiqing Liao
Summary: This study evaluated the diagnostic accuracy of AI algorithms in detecting tumor metastasis using medical radiology imaging. The results showed that AI algorithms may perform as well as or even better than healthcare professionals in terms of sensitivity and specificity. Different AI algorithms, such as machine learning and deep learning, showed varying levels of sensitivity and specificity.
