Geometric regulation of histone state directs melanoma reprogramming

PRDM14 controls X-chromosomal and global epigenetic reprogramming of H3K27me3 in migrating mouse primordial germ cells

(2019) Anna Mallol et al.   Epigenetics & Chromatin

Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice

(2017) Michael C. Saul et al.   GENOME RESEARCH

Melanoma topology reveals a stem-like phenotype that promotes angiogenesis

(2017) Junmin Lee et al.   Science Advances

Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells

(2016) Mei-Fong Pang et al.   CANCER RESEARCH

Interfacial geometry dictates cancer cell tumorigenicity

(2016) Junmin Lee et al.   NATURE MATERIALS

PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency

(2016) Naoki Okashita et al.   Stem Cell Reports

The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers

(2014) Brianna J. Klein et al.   Cell Reports

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Single-Cell Profiling of Epigenetic Modifiers Identifies PRDM14 as an Inducer of Cell Fate in the Mammalian Embryo

(2013) Adam Burton et al.   Cell Reports

Epiblast Stem Cell-Based System Reveals Reprogramming Synergy of Germline Factors

(2012) Astrid Gillich et al.   Cell Stem Cell

Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

(2012) Olga Shakhova et al.   NATURE CELL BIOLOGY

Radiation-Induced Reprogramming of Breast Cancer Cells

(2012) Chann Lagadec et al.   STEM CELLS

PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells

(2011) Masakazu Yoshida et al.   BIOCHEMICAL JOURNAL

Binding of the JmjC Demethylase JARID1B to LSD1/NuRD Suppresses Angiogenesis and Metastasis in Breast Cancer Cells by Repressing Chemokine CCL14

(2011) Q. Li et al.   CANCER RESEARCH

Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells

(2011) P. C. Hollenhorst et al.   GENES & DEVELOPMENT

ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma

(2011) Barbara Spangler et al.   INTERNATIONAL JOURNAL OF CANCER

Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors

(2011) E J Dettman et al.   ONCOGENE

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis

(2010) Isabel Ben-Batalla et al.   JOURNAL OF CLINICAL INVESTIGATION

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

(2010) Na-Yu Chia et al.   NATURE

Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates

(2010) Ziyang Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex

(2009) Johannes von Burstin et al.   GASTROENTEROLOGY

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE

Critical function of Prdm14 for the establishment of the germ cell lineage in mice

(2008) Masashi Yamaji et al.   NATURE GENETICS

Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

(2008) Leighton J. Core et al.   SCIENCE