期刊
ISCIENCE
卷 23, 期 8, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2020.101395
关键词
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资金
- National Natural Science Foundation of China [21801011, 21825101, 21602007]
- China Postdoctoral Science Foundation [2018M630022]
- International Postdoctoral Exchange Fellowship Program [20180033]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011641]
- Shenzhen Basic Research Funds [JCYJ20170818085510474, JCYJ20170818085438996]
Polysubstituted bicyclic acetals are a class of privileged pharmacophores with a unique 3D structure and an adjacent pair of hydrogen bond acceptors. The key, fused acetal functionality is often assembled, via intramolecular cyclization, from linear substrates that are not readily available. Herein, we report a formal cycloaddition between cinnamyl alcohols and cyclic enol ethers under ambient photoredox catalysis conditions. Polysubstituted bicyclic acetals can be prepared in one step from readily available building blocks. Employment of sugar-derived enol ethers allows easy access to a library of scaffolds with intriguing conforma-tion and medicinal chemistry potential.
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