期刊
ISCIENCE
卷 23, 期 5, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2020.101078
关键词
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资金
- European Union (EU FP6 MEMORIES) [037831]
- European Union (EU FP6 StemStroke) [037526]
- BBSRC [BB/L021382/1]
- European Union's Horizon 2020 Framework Program for Research and Innovation [785907]
- Telethon, Italy [GGP 16083]
- ESTAR fellowship - EC's FP6 Marie Curie host fellowship for Early Stage Research Training [MECC-BFU2014-56692-R, MEST-CT-2004-504640]
- BBSRC [BB/L021382/1] Funding Source: UKRI
Early in brain development, impaired neuronal signaling during time-sensitive windows triggers the onset of neurodevelopmental disorders. GABA, through its depolarizing and excitatory actions, drives early developmental events including neuronal circuit formation and refinement. BDNF/TrkB signaling cooperates with GABA actions. How these developmental processes influence the formation of neural circuits and affect adult brain function is unknown. Here, we show that early deletion of Ntrk2/Trkb from immature mouse hippocampal dentate granule cells (DGCs) affects the integration and maturation of newly formed DGCs in the hippocampal circuitry and drives a premature shift from depolarizing to hyperpolarizing GABAergic actions in the target of DGCs, the CA3 principal cells of the hippocampus, by reducing the expression of the cation-chloride importer Nkcc1. These changes lead to the disruption of early synchronized neuronal activity at the network level and impaired morphological maturation of CA3 pyramidal neurons, ultimately contributing to altered adult hippocampal synaptic plasticity and cognitive processes.
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