期刊
BLOOD ADVANCES
卷 4, 期 10, 页码 2261-2271出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/bloodadvances.2020001636
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资金
- National Institutes of Health, National Cancer Institute cancer center support grant [P30 CA008748]
- National Institutes of Health, National Cancer Institute [P50 CA192937]
- NATIONAL CANCER INSTITUTE [ZIEBC011384] Funding Source: NIH RePORTER
TET2 and DNMT3A mutations are frequently identified in T-cell lymphomas of T follicular helper cell origin (TCL-TFH), clonal hematopoiesis (CH), and myeloid neoplasms (MNs). The relationships among these 3 entities, however, are not well understood. We performed comprehensive genomic studies on paired bone marrow and tissue samples as well as on flow cytometry-sorted bone marrow and peripheral blood iu subpopulations from a cohort of 22 patients with TCL-TFH to identify shared CH-type mutations in various hematopoietic cell compartments. Identical mutations were detected in the neoplastic T-cell and myeloid compartments of 15 out of 22 patients (68%), including TET2 (14/15) and DNMT3A (10/15). Four patients developed MNs, all of which shared CH-type mutations with their TCL-TFH; additional unique genetic alterations were also detected in each patient's TCL-TFH and MN. These data demonstrate that CH is prevalent in patients with TCL-TFH and that divergent evolution of a CH clone may give rise to both TCL-TFH and MNs.
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