Review
Medicine, General & Internal
Davide Ceccato, Angelo Di Vincenzo, Claudio Pagano, Raffaele Pesavento, Paolo Prandoni, Roberto Vettor
Summary: In obese hospitalized patients, weight-adjusted dose heparin is not associated with a lower risk of VTE or a higher risk of bleeding compared to fixed-dose heparins. However, it is associated with higher anti-Xa levels.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Nuccia Morici, GianMarco Podda, Simone Birocchi, Luca Bonacchini, Marco Merli, Michele Trezzi, Gianluca Massaini, Marco Agostinis, Giulia Carioti, Francesco Saverio Serino, Gianluca Gazzaniga, Daniela Barberis, Laura Antolini, Maria Grazia Valsecchi, Marco Cattaneo
Summary: This study investigated whether higher doses of anticoagulants are necessary for COVID-19 patients hospitalized in general wards. The results showed no significant difference in thromboprophylaxis efficacy between 40 mg b.i.d. and 40 mg o.d. enoxaparin in these patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Miguel Cervero, Daniel Lopez-Wolf, Guiomar Casado, Maria Novella-Mena, Pablo Ryan-Murua, Maria Luisa Taboada-Martinez, Sara Rodriguez-Mora, Lorena Vigon, Mayte Coiras, Montserrat Torres
Summary: There is sufficient evidence to support that vitamin D deficiency may increase susceptibility to SARS-CoV-2 infection and severity of COVID-19. This study conducted a small clinical trial in hospitalized patients and found that daily supplementation of 10,000 IU of vitamin D-3 can safely and effectively reduce the duration and severity of COVID-19.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Julie Schjodtz Hansen, Stefan Gustavsen, Homayoun Roshanisefat, Matthias Kant, Fin Biering-Sorensen, Claus Andersen, Anna Olsson, Helene Hojsgaard Chow, Nasrin Asgari, Julie Richter Hansen, Helle Hvilsted Nielsen, Rikke Middelhede Hansen, Thor Petersen, Annette Bang Oturai, Finn Sellebjerg, Eva Aggerholm Saedder, Helge Kasch, Peter Vestergaard Rasmussen, Nanna Brix Finnerup, Kristina Bacher Svendsen
Summary: This study investigated the effect of cannabis-based medicine (CBM) on central neuropathic pain (NP) and spasticity in patients with multiple sclerosis (MS) and spinal cord injury (SCI). The results showed that THC, CBD, or their combination did not have a significant effect on pain and spasticity. The study was limited by a smaller sample size due to COVID-19 and recruitment challenges.
Article
Surgery
Piotr Witkowski, Martin Wijkstrom, Piotr J. Bachul, Katherine A. Morgan, Marlon Levy, Nicholas Onaca, Sushela S. Chaidarun, Timothy Gardner, A. M. James Shapiro, Andrew Posselt, Syed A. Ahmad, Luisa Daffonchio, Pier A. Ruffini, Melena D. Bellin
Summary: The use of reparixin for islet autotransplantation in patients undergoing total pancreatectomy did not significantly improve outcomes. Inhibiting the CXCL8 pathway alone may not be sufficient to prevent islet damage in transplantation procedures. This first multicenter clinical trial in TPIAT shows potential for future collaborations.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Gregg W. Stone, Michael E. Farkouh, Anuradha Lala, Elizabeth Tinuoye, Ovidiu Dressler, Pedro R. Moreno, Igor F. Palacios, Shaun G. Goodman, Rodrigo B. Esper, Alexandre Abizaid, Deepak Varade, Juan F. Betancur, Alejandro Ricalde, Gerardo Payro, Jose Maria Castellano, Ivan F. N. Hung, Girish N. Nadkarni, Gennaro Giustino, Lucas C. Godoy, Jason Feinman, Anton Camaj, Solomon W. Bienstock, Remo H. M. Furtado, Carlos Granada, Jessica Bustamante, Carlos Peyra, Johanna Contreras, Ruth Owen, Deepak L. Bhatt, Stuart J. Pocock, Valentin Fuster
Summary: This study aimed to determine the safety and effectiveness of therapeutic-dose anticoagulation in noncritically ill patients with COVID-19. The results showed that therapeutic-dose anticoagulation reduced the all-cause mortality and intubation rate compared to prophylactic-dose anticoagulation, but did not significantly improve the 30-day primary composite outcome.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Microbiology
Xiaoqian Wang, Lihong Chen, Hongjie Ruan, Zhengai Xiong, Wenying Wang, Jin Qiu, Weihua Song, Chunlian Zhang, Fengxia Xue, Tianhua Qin, Bei Zhang, Ruifang An, Xiping Luo, Wei Wang, Songling Zhang, Yunlang Cai, Jiali Kang, Henan Deng, Shangrong Fan, Manhua Cui, Shijin Wang, Xiaowan Luo, Zhiying Su, Jing Shu, Quanren Wang, Fang Wang, Jianling Bai, Qinping Liao, Damian J. Krysan
Summary: Fluconazole remains the dominant treatment option for severe vulvovaginal candidiasis (VVC), but this study found that Oteseconazole demonstrated significant and clinically meaningful superiority in treating severe VVC with good tolerability.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Surgery
K. J. Steinthorsdottir, H. N. Awada, N. A. Schultz, P. N. Larsen, J. G. Hillingso, O. Jans, H. Kehlet, E. K. Aasvang
Summary: In patients undergoing open liver resection surgery, a single high dose of preoperative glucocorticoids did not reduce the incidence of postoperative complications compared to a standard dose. Other outcomes, such as hospital stay duration and 30-day morbidity, were similar between the two groups.
Article
Plant Sciences
Sungha Kim, Muhack Yang, Boncho Ku, Eunhye Cha, Wookcheol Seo, Ilhong Son, Hyungwon Kang, Dongwoung Kim, Bongkeun Song, Chang-Sop Yang, Sungchul Kim
Summary: This study aimed to evaluate the efficacy and safety of Mecasin in patients with ALS. Patients were randomized to receive daily doses of 1.6 g or 2.4 g Mecasin, or placebo for 12 weeks. The results showed that Mecasin can slow down the progression of symptoms in ALS patients without major adverse effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Feihe Guo, Cuicui Jiao, Kaihong Xu, Chunbo Yang, Xiadi Huang, Yongchao Lu, Lili Xu, Xinzhong Chen
Summary: The study aimed to determine the optimal effective dose of pituitrin in laparoscopic myomectomy for uterine leiomyoma. The results showed that 2 units of pituitrin could provide a satisfactory surgical field with minimal hemodynamic changes.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Plant Sciences
Yihe Chi, Lin Lin, Xin Guo, Jingmin Xiao, Feiting Fan, Changli Yu, Hanrong Xue, Suyun Li, Dongwei Guo, Lei Liu, Yaoyong Wang, Xiao Ma, Jianguo Pang, Jincheng Wang, Zhiying Zhao, Xianping Zhao, Guangen Wang, Dongwei Gu, Hui Zhen, Hongping Chen, Junping Ding, Mingjuan Zhou, Zhenhu Wu, Yun Han, Yuanbin Chen, Lei Wu
Summary: XBZK granules are a promising therapy for postinfectious cough, effectively reducing the severity of cough, shortening the time for cough recovery, and decreasing the viscosity of sputum.
Article
Cardiac & Cardiovascular Systems
Marco G. Mennuni, Giulia Renda, Leonardo Grisafi, Andrea Rognoni, Crizia Colombo, Veronica Lio, Melissa Foglietta, Ivan Petrilli, Mario Pirisi, Enrico Spinoni, Danila Azzolina, Eyal Hayden, Gianluca Aimaretti, Gian Carlo Avanzi, Mattia Bellan, Vincenzo Cantaluppi, Andrea Capponi, Luigi M. Castello, Damiano D'Ardes, Francesco Della Corte, Sabina Gallina, Marco Krengli, Mario Malerba, Sante D. Pierdomenico, Paola Savoia, Patrizia Zeppegno, Pier P. Sainaghi, Francesco Cipollone, Giuseppe Patti
Summary: In patients hospitalized for COVID-19, the use of prophylactic dose of enoxaparin appears to be associated with similar in-hospital overall mortality compared to higher doses, but significantly lower incidence of adverse events such as cardiovascular death, venous thromboembolism, new-onset ARDS, and mechanical intubation. These findings need to be confirmed in a randomized, controlled study.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Pharmacology & Pharmacy
Markus Zadrazil, Peter Marhofer, Werner Schmid, Daniela Marhofer, Philipp Opfermann
Summary: ADV6209, a new formulation of midazolam with the addition of gamma-cyclodextrin for oral use, has been shown to have similar efficacy to the standard formulation in reducing preoperative anxiety in children. However, it is better orally accepted, making it a more suitable option for pediatric sedation.
Article
Critical Care Medicine
Richard Onalo, Antoinette Cilliers, Peter Cooper, Claudia R. Morris
Summary: This study found that oral arginine supplementation can improve cardiopulmonary hemodynamics in children with sickle cell anemia experiencing pain. After supplementation, the patients showed improved indices of cardiopulmonary function, and there was a negative correlation with markers of arginine bioavailability.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Hematology
Stefano Barco, Davide Voci, Ulrike Held, Tim Sebastian, Roland Bingisser, Giuseppe Colucci, Daniel Duerschmied, Andre Frenk, Bernhard Gerber, Andrea Goetschi, Stavros Konstantinides, Francois Mach, Helia Robert-Ebadi, Thomas Rosemann, Noemi R. Simon, Herve Spechbach, David Spirk, Stefan Stortecky, Lukas Vaisnora, Marc Righini, Nils Kucher
Summary: This study aimed to investigate whether thromboprophylaxis with enoxaparin would prevent hospitalization and death in symptomatic COVID-19 outpatients. The results showed that enoxaparin did not reduce the risk of hospitalization and death among these patients.
LANCET HAEMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Bruno Bockorny, Andrea J. Bullock, Thomas A. Abrams, Salomao Faintuch, David C. Alsop, S. Nahum Goldberg, Muneeb Ahmed, Rebecca A. Miksad
Summary: The study evaluated the efficacy of short-course sorafenib prior to RFA for HCC tumors and found that sorafenib did not increase the size of the ablation zone achieved with RFA, but significantly decreased tumor blood perfusion. Sorafenib was well-tolerated with no grade 4 toxicity observed. Future research should investigate alternative antiangiogenic strategies to enhance RFA efficacy.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Oncology
Joseph E. Grossman, Lakshmi Muthuswamy, Ling Huang, Dipikaa Akshinthala, Sofia Perea, Raul S. Gonzalez, Leo L. Tsai, Jonah Cohen, Bruno Bockorny, Andrea J. Bullock, Benjamin Schlechter, Mary Linton B. Peters, Catherine Conahan, Supraja Narasimhan, Christine Lim, Roger B. Davis, Robert Besaw, Mandeep S. Sawhney, Douglas Pleskow, Tyler M. Berzin, Martin Smith, Tara S. Kent, Mark Callery, Senthil K. Muthuswamy, Manuel Hidalgo
Summary: This pilot feasibility trial investigated the use of patient-derived organoids (PDOs) to guide personalized therapy for pancreatic ductal adenocarcinoma (PDAC). The study found that the drug sensitivity of PDOs can predict the clinical outcome of patients and is correlated with treatment responses.
CLINICAL CANCER RESEARCH
(2022)
Article
Hematology
Eric J. Miller, Rushad Patell, Erik J. Uhlmann, Siyang Ren, Hannah Southard, Pavania Elavalakanar, Griffin M. Weber, Donna Neuberg, Jeffrey Zwicker
Summary: In this study, the influence of antiplatelet agents on the development of brain tumor-associated intracranial hemorrhage (ICH) was analyzed. It was found that the use of antiplatelet agents did not increase the risk of ICH, nor did it affect the incidence, size, or severity of ICH in patients with brain metastases.
Letter
Oncology
Joan How, Kathleen M. E. Gallagher, Yiwen Liu, Katelin Katsis, Eva L. Elder, Rebecca C. Larson, Mark B. Leick, Donna Neuberg, Marcela V. Maus, Gabriela S. Hobbs
Article
Medicine, General & Internal
Adeel M. Khan, Thita Chiasakul, Robert Redd, Rushad Patell, Ellen P. McCarthy, Donna Neuberg, Jeffrey I. Zwicker
Summary: This study analyzed the overall survival of cancer patients treated with warfarin or direct oral anticoagulants (DOACs) for venous thromboembolism (VTE). The findings suggest that warfarin is associated with prolonged overall survival compared to DOACs in the treatment of VTE in cancer patients. These results indicate that warfarin may be a better option for the treatment of cancer-associated VTE.
Review
Oncology
Bruno Bockorny, Joseph E. Grossman, Manuel Hidalgo
Summary: Pancreatic ductal adenocarcinoma (PDAC) remains a challenging cancer to treat. Chemotherapy has limited benefits and immunotherapy has made little progress. However, recent advances in understanding the tumor microenvironment and new approaches to immunotherapy have provided hope. Improvements in preclinical models, targeting the tumor microenvironment, and identifying biomarkers will likely lead to better selection of patients who could benefit from immunotherapy. Urgent research is needed to design effective combination trials to cure patients with PDAC.
CLINICAL CANCER RESEARCH
(2022)
Letter
Hematology
Maureen Okam Achebe, Elyse Mandell, Katherine Jolley, Hae Soo Park, Revital Freedman, Siyang Ren, Donna Neuberg, Michael Auerbach
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
Charles Hsu, Rushad Patell, Jeffrey I. Zwicker
Summary: Venous thromboembolism (VTE) and thrombocytopenia are common complications in patients with cancer. This study evaluated the prevalence of thrombocytopenia among patients with acute cancer-associated thrombosis (CAT) and found that concurrent diagnoses of CAT and thrombocytopenia are very common, especially in patients with hematologic malignancies.
Article
Oncology
Livius Penter, Elisa ten Hacken, Jackson Southard, Caleb A. Lareau, Leif S. Ludwig, Shuqiang Li, Donna S. Neuberg, Kenneth J. Livak, Catherine J. Wu
Summary: Murine models are essential for functional genomic studies and preclinical testing. A study using mtscATAC-seq technology on murine cancer models found mtDNA mutations and provided insights into disease biology and therapeutic vulnerabilities. This demonstrates the feasibility and utility of multi-modal single-cell and natural barcoding approaches.
Article
Multidisciplinary Sciences
David K. Y. Zhang, Kwasi Adu-Berchie, Siddharth Iyer, Yutong Liu, Nicoletta Cieri, Joshua M. Brockman, Donna Neuberg, Catherine J. Wu, David J. Mooney
Summary: Personalizing the level of stimulation during T-cell activation enhances CAR-T functionality.
NATURE COMMUNICATIONS
(2023)
Letter
Biophysics
Sharmila Raghunandan, Lev Gorfinkel, Brandi Bratrude, Yvonne Suessmuth, Kyle Hebert, Donna Neuberg, Kirsten M. Williams, Michelle L. Schoettler, Amelia A. Langston, Leslie S. Kean, Muna Qayed, John Horan, Benjamin K. Watkins
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Franziska Wachter, Kyle Hebert, Yana Pikman, Jiemin Yang, Binita Shah, Jacob Bledsoe, Akiko Shimamura, Donna S. Neuberg, Jessica A. Pollard, Leslie E. Lehmann
Summary: The role of cytoreduction prior to hematopoietic cell transplant (HCT) for pediatric patients with myelodysplastic syndrome (MDS) and related disorders is still uncertain. This retrospective analysis examined the pre-transplant disease management and HCT outcomes for pediatric patients with MDS and related disorders who underwent HCT between 2010 and 2020. The results showed that cytoreduction did not provide a survival benefit overall, but patients who achieved measurable residual disease (MRD) negativity after cytoreduction had improved overall survival compared to those with persistent disease.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Jennifer J. G. Welch, Yael Flamand, Kristen E. E. Stevenson, Donna S. S. Neuberg, Uma H. H. Athale, Kara M. M. Kelly, Caroline Laverdiere, Bruno Michon, Andrew E. E. Place, Stephen E. E. Sallan, Lewis B. B. Silverman, Lynda M. M. Vrooman
Summary: This study examines the health-related quality of life (HR-QoL) of children with acute lymphoblastic leukemia (ALL) during treatment. It found that children with ALL experience substantial impairment in HR-QoL, particularly related to fatigue during treatment involving asparaginase.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Medicine, Research & Experimental
Oluwatoyosi Muse, Rushad Patell, Christian G. Peters, Moua Yang, Emale El-Darzi, Sol Schulman, Anna Falanga, Marina Marchetti, Laura Russo, Jeffrey I. Zwicker, Robert Flaumenhaft
Summary: Thrombosis is a common complication of advanced cancer, and our study reveals that activation of the unfolded protein response (UPR) in cancer cells can lead to increased release of prothrombotic particles, providing a mechanistic link between ER stress and cancer-associated thrombosis.
Article
Hematology
Lakshmanan Krishnamurti, Donna Neuberg, Keith M. Sullivan, Shannon Smith, Mary Eapen, Mark C. Walters
Summary: This study aimed to compare the efficacy of bone marrow transplantation (BMT) with gene therapy in sickle cell disease (SCD), but it was prematurely closed due to recruitment difficulties. Barriers to enrollment included a shortage of suitable donors, exclusion of individuals with previously identified donors, preferences for conventional care among SCD patients, and the impact of the pandemic on recruitment, among others.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)