Article
Medicine, General & Internal
Anders Pretzmann Mikkelsen, Iben Katinka Greiber, Nikolai Madrid Scheller, Ojvind Lidegaard
Summary: A nationwide retrospective cohort study in Denmark found no significant association between maternal exposure to epidural analgesia during labor and autism spectrum disorder in offspring.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Behavioral Sciences
Adele M. Dimian, Annette Estes, Stephen Dager, Joseph J. Piven, Jason Wolff, IBIS Network
Summary: Self-injurious behavior (SIB) is common in individuals with autism spectrum disorder (ASD) and can occur at different ages. Previous research has shown a link between SIB at 12 months and SIB at 24 months. This study extends these findings by examining SIB occurrence and associated risk factors at 36 months. The results show that a diagnosis of ASD, SIB at 12 months, stereotypy, hyper- and hypo- sensory responsivity, and lower intellectual functioning are significant predictors of SIB at 36 months.
Article
Health Care Sciences & Services
Jade Horsnell, Stephen Mangar, Dagmara Dimitriou, Elizabeth J. Halstead
Summary: This study investigated parental experiences and motivations for using melatonin to manage sleep disturbances in their autistic children. Results showed that some parents believed melatonin improved their child's sleep, while others reported limited or diminishing effects. Suggestions were made for healthcare professionals and families to establish clear guidelines and manage expectations when using melatonin.
Article
Behavioral Sciences
Ashley Y. Song, Kelly Bakulski, Jason Feinberg, Craig Newschaffer, Lisa A. Croen, Irva Hertz-Picciotto, Rebecca J. Schmidt, Homayoon Farzadegan, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta
Summary: This study found that accelerated epigenetic aging in mothers was associated with lower cognitive ability and function in offspring at 12 months, while accelerated maternal epigenetic aging was marginally associated with increased odds of ASD in offspring at 36 months. On the other hand, father's accelerated aging was marginally associated with decreased ASD risk in their offspring. This suggests that epigenetic aging in parents may play a role in neurodevelopment and ASD risk.
Article
Multidisciplinary Sciences
Masud Rabbani, Munirul M. Haque, Dipranjan Das Dipal, Md Ishrak Islam Zarif, Anik Iqbal, Amy Schwichtenberg, Naveen Bansal, Tanjir Rashid Soron, Syed Ishtiaque Ahmed, Sheikh Iqbal Ahamed
Summary: This study aimed to evaluate the behavioral patterns of children with ASD during and after the COVID-19 lockdown, and found that support in the areas of problematic behavior could mitigate future risks.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Multidisciplinary
Yuanting Lin, Yan Wang, Chunhui Lin, Qingnan Ni, Ruolin Jia, Yanling Chang, YuanPing Qi
Summary: This study examines the connection between parental burnout and alexithymia among parents of autistic children. It finds that parents of autistic children are more prone to experiencing parental burnout, and there is a relationship between parental burnout and parents' personality traits. The study also reveals that social support is negatively related to both alexithymia and parental burnout.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Developmental
Maria Sanchez, Jennifer C. Bullen, Matthew C. Zajic, Nancy McIntyre, Peter Mundy
Summary: This study examined differences in internalizing and externalizing behaviors between boys and girls diagnosed with autism spectrum disorder (ASD). Girls showed higher instances of bullying, less anger control, and poorer emotional self-control compared to boys. There were no differences between the groups in terms of social communication. Further research is needed to investigate the lesser known area of externalizing behaviors in girls with ASD.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Jingnan Du, Edmund T. Rolls, Weikang Gong, Miao Cao, Deniz Vatansever, Jie Zhang, Jujiao Kang, Wei Cheng, Jianfeng Feng
Summary: The study showed that children of younger mothers tend to have more behavioral and cognitive problems, which are associated with lower volumes of certain cortical regions. The findings suggest that parental age is linked to behavioral issues and cognitive decline in children.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Wen-Xiong Chen, Xian Liu, Zhifang Huang, Cheng Guo, Fangmei Feng, Yani Zhang, Yuanyuan Gao, Kelu Zheng, Jingyu Huang, Jing Yu, Wenqing Wei, Simin Liang
Summary: This study explored the relationship between clinical profiles and age at first concern and diagnosis among autistic children. The results showed that language delay and regression were associated with earlier diagnostic age. Language delay was more strongly associated with earlier diagnosis among male children and those from higher socioeconomic backgrounds.
FRONTIERS IN PSYCHIATRY
(2023)
Letter
Medicine, General & Internal
James T. Nugent, Christine Bakhoum, Lama Ghazi, Jason H. Greenberg
Summary: This study compares the frequency of hypertension screening at health maintenance visits between children with and without autism.
Article
Psychology, Developmental
T. St John, A. Estes, K. K. Begay, J. Munson, M. A. Reiter, S. R. Dager, N. Kleinhans
Summary: Children with sensory abnormalities exhibit poorer social functioning compared to typically developing children, and have similar social functioning levels to those with autism spectrum disorder. Increased sensory abnormalities are associated with worse social functioning in all groups, highlighting the need for interventions to support social functioning in this population.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Environmental Sciences
Johanna Inhyang Kim, Jung Lee, Kyung-Shin Lee, Young Ah Lee, Choong Ho Shin, Yun-Chul Hong, Bung-Nyun Kim, Youn-Hee Lim
Summary: This study found that exposure to certain phthalate metabolites during pregnancy can lead to increased autistic traits in young children, while exposure to other metabolites during early childhood may result in autistic traits in older school-aged children, especially boys.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Psychology, Multidisciplinary
Lori-Ann R. Sacrey, Lonnie Zwaigenbaum, Susan E. Bryson, Jessica A. Brian, Isabel M. Smith, Nancy Garon, Tracy Vaillancourt, Caroline Roncadin
Summary: This study examines the relationship between temperament in infancy and internalizing and externalizing behavior at age 5, and finds that temperament is linked to later mental health conditions. Specifically, certain temperament traits in infancy predict internalizing and externalizing problems at age 5.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Health Care Sciences & Services
Alessandro Musetti, Tommaso Manari, Barbara Dioni, Cinzia Raffin, Giulia Bravo, Rachele Mariani, Gianluca Esposito, Dagmara Dimitriou, Giuseppe Plazzi, Christian Franceschini, Paola Corsano
Summary: The study found that increased parental involvement in interventions for children or adolescents with ASD may be a way to improve their quality of life. However, further research focusing specifically on parental involvement during interventions for children and adolescents with ASD is needed.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Jingyuan Xiao, Yu Gao, Yongfu Yu, Gunnar Toft, Yawei Zhang, Jiajun Luo, Yuntian Xia, Katarzyna Chawarska, Jorn Olsen, Jiong Li, Zeyan Liew
Summary: Offspring of parents born with adverse characteristics had an elevated risk for ASD, with parents born very preterm potentially doubling the risk for their children. Parental social-mental and offspring perinatal factors may explain a portion of this risk.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Ophthalmology
Meiyan Li, Danjuan Yang, Yang Shen, Jianmin Shang, Lingling Niu, Yongfu Yu, Xiaoying Wang, Peijun Yao, Xingtao Zhou
Summary: This study aimed to compare mydriatic and eye-steering ultrawide field imaging with standard non-mydriatic ultrawide field imaging in detecting peripheral retinal lesions in myopic patients. The results showed that both mydriasis and eye-steering technique significantly increased the sensitivity of detecting peripheral lesions, especially those located in the superior and inferior quadrants.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
Tai Ren, Priscilla Ming Yi Lee, Fei Li, Jiong Li
Summary: This study aimed to investigate whether children born to mothers who used carbamazepine during pregnancy had worse academic performance in adolescence. The results showed that offspring exposed to maternal carbamazepine monotherapy during pregnancy had lower scores in Danish and mathematics in the ninth-grade exit examination.
Article
Medicine, General & Internal
Hua Chen, Imre Janszky, Mikael Rostila, Dang Wei, Fen Yang, Jiong Li, Krisztina D. Laszlo
Summary: This study investigated whether the loss of a parent or sibling in childhood is associated with an increased risk of atrial fibrillation (AF) and found that both childhood and adulthood bereavement were associated with an increased AF risk.
Article
Psychiatry
Hui Yang, Di Sun, Yating Yang, Ruilang Lin, Jiaqin Xu, Jingyi Wu, Xiaorui Cui, Jiong Li, Guoyou Qin, Xiaojie Han, Yongfu Yu
Summary: This study found that depression was associated with all-cause mortality among individuals at a high baseline risk of CVD, but no significant association was observed in people at a low baseline risk of CVD.
PSYCHIATRY RESEARCH
(2023)
Article
Environmental Sciences
Zixia Wang, Jiajun Luo, Yan Zhang, Jiong Li, Jun Zhang, Ying Tian, Yu Gao
Summary: The study suggests that maternal glucose level may affect the association between prenatal PFAS exposure and birth weight. The negative correlation between PFAS concentration and birth weight z-score is more pronounced in the high glucose group, and the correlation becomes stronger as the glucose level increases. These findings indicate that high glucose levels may increase the risk of reduced birth weight related to PFAS exposure, and provide intervention strategies for pregnant women with high PFAS exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Kejia Hu, Qianwei Liu, Krisztina D. Laszlo, Dang Wei, Fen Yang, Katja Fall, Hans-Olov Adami, Weimin Ye, Unnur A. Valdimarsdottir, Jiong Li, Fang Fang
Summary: There is evidence indicating a higher prevalence of mental illness among spouses of cancer patients. This study aimed to assess the burden of psychiatric disorders among spouses of cancer patients and describe its changes over time. The findings emphasize the importance of clinical attention to prevent mental illness among these spouses.
Article
Oncology
Yiliang Zhang, Longfu Zhang, Bin Li, Ting Ye, Yang Zhang, Yongfu Yu, Yuan Ma, Yihua Sun, Jiaqing Xiang, Yike Li, Haiquan Chen
Summary: This study applied machine learning to predict the metastasis of recurrent laryngeal nerve (RLN) lymph nodes in esophageal squamous cell carcinoma (ESCC). Models were established using baseline and pathological features of 3352 surgically treated ESCC patients, achieving high negative predictive values and suggesting potential intraoperative applications to spare RLN node dissection.
Article
Cardiac & Cardiovascular Systems
Jingyi Wu, Xiaojie Han, Di Sun, Jie Zhang, Jiong Li, Guoyou Qin, Wei Deng, Yongfu Yu, Huilin Xu
Summary: This study aimed to investigate the age-specific association between hypertension stage at diagnosis and cardiovascular mortality or all-cause mortality among elderly hypertensive patients. The findings showed that compared to stage 1 hypertension, stage 3 hypertension was associated with a higher risk of cardiovascular mortality and all-cause mortality in different age groups, with stronger effects in the 60-69 age group.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Medicine, General & Internal
Liu Yang, Chen Huang, Min Zhao, Priscilla M. Y. Lee, Cheng Zhang, Yongfu Yu, Bo Xi, Jiong Li
Summary: This study aimed to assess the impact of maternal hypertensive disorders (HDP) on the development of diabetes in offspring from childhood to early adulthood. Using Danish national health registers, 2,448,753 individuals born in Denmark from 1978 to 2018 were included. The results showed that offspring of mothers with HDP had an increased risk of diabetes, suggesting that timely and effective prevention of HDP should be considered as a strategy for diabetes prevention and control in future generations.
Article
Medicine, General & Internal
Hui Wang, Priscilla Ming Yi Lee, Jun Zhang, Katrine Svendsen, Fei Li, Jiong Li
Summary: Individuals with intellectual disability are at increased risk of early-onset cardiovascular diseases, particularly cerebrovascular disease, stroke, heart failure, and deep vein thrombosis. The severity of intellectual disability is positively associated with the risk of cardiovascular diseases. This study highlights the importance of recognizing the cardiovascular disease risks in individuals with intellectual disability.
Correction
Medicine, General & Internal
Jiahong Sun, Ce Wang, Min Zhao, Priscilla M. Y. Lee, Bo Xi, Yongfu Yu, Jiong Li
Article
Medicine, General & Internal
Min Luan, Fen Yang, Maohua Miao, Wei Yuan, Mika Gissler, Elizabeth V. Arkema, Donghao Lu, Jiong Li, Krisztina D. Laszlo
Summary: Postpartum psychiatric disorders (PPD) are common complications of childbirth. This study found that women with rheumatoid arthritis (RA) had a higher risk of developing PPD, especially if they had no previous history of psychiatric disorders.
Article
Gastroenterology & Hepatology
Jiong Li, Jiawen Chen, Priscilla Ming Yi Lee, Jun Zhang, Fei Li, Tai Ren
Summary: This study evaluated the familial recurrence of intrahepatic cholestasis of pregnancy (ICP). The results showed that co-twins and first-degree relatives of ICP patients had a similar 5-fold and 2.5-fold increased risk of ICP, respectively. No increased risk was observed in second-degree and third-degree relatives. Further investigation is needed to understand the increased risk of ICP in nonbiological relatives.
Article
Urology & Nephrology
Bingxin Jiang, Dongxu Tang, Neng Dai, Chen Huang, Yahang Liu, Ce Wang, Jiahuan Peng, Guoyou Qin, Yongfu Yu, Jiaohua Chen
Summary: This cohort study aimed to examine the association between nighttime sleep duration and chronic kidney disease (CKD), as well as the impact of daytime napping on this association. The results showed that short or persistent long or short nighttime sleep duration were associated with an increased risk of CKD onset. However, maintaining optimal nighttime sleep duration may help reduce the risk of CKD. Additionally, daytime napping may be protective against CKD onset.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)