Fructose contributes to the Warburg effect for cancer growth

Fructose Production and Metabolism in the Kidney

(2020) Takahiko Nakagawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction

(2020) Ana Andres-Hernando et al.   Cell Metabolism

High-fructose corn syrup enhances intestinal tumor growth in mice

(2019) Marcus D. Goncalves et al.   SCIENCE

Isocaloric Fructose Restriction Reduces Serum D-Lactate Concentration in Children With Obesity and Metabolic Syndrome

(2019) Ayca Erkin-Cakmak et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys

(2019) Jeffrey B. Schwimmer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

(2019) Samir Softic et al.   Cell Metabolism

Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts

(2019) R. J. Johnson et al.   JOURNAL OF INTERNAL MEDICINE

GLUT5 increases fructose utilization and promotes tumor progression in glioma

(2018) Chunhai Su et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma

(2018) Wenbo Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis

(2018) Pengcheng Bu et al.   Cell Metabolism

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids

(2018) Cholsoon Jang et al.   Cell Metabolism

Fructose metabolism and metabolic disease

(2018) Sarah A. Hannou et al.   JOURNAL OF CLINICAL INVESTIGATION

High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism

(2018) Miguel A. Lanaspa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fructose fuels lung adenocarcinoma through GLUT5

(2018) Yuanyuan Weng et al.   Cell Death & Disease

Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity

(2017) Jean-Marc Schwarz et al.   GASTROENTEROLOGY

More pieces of the fructose puzzle

(2017) K. L. Stanhope   JOURNAL OF INTERNAL MEDICINE

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

(2017) Thomas J. Park et al.   SCIENCE

Fructose Metabolism from a Functional Perspective: Implications for Athletes

(2017) Luc Tappy et al.   SPORTS MEDICINE

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

(2017) Ana Andres-Hernando et al.   Nature Communications

Short-term isocaloric fructose restriction lowers apoC-III levels and yields less atherogenic lipoprotein profiles in children with obesity and metabolic syndrome

(2016) Alejandro Gugliucci et al.   ATHEROSCLEROSIS

Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential

(2016) Wen-Lian Chen et al.   CANCER CELL

A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway

(2016) Y. Jiang et al.   CANCER RESEARCH

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation

(2016) Xinjian Li et al.   NATURE CELL BIOLOGY

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease

(2015) Peter Mirtschink et al.   NATURE

Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome

(2015) Robert H. Lustig et al.   Obesity

Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy

(2014) M. A. Lanaspa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fructokinase activity mediates dehydration-induced renal injury

(2013) Carlos A. Roncal Jimenez et al.   KIDNEY INTERNATIONAL

Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

(2013) Miguel A. Lanaspa et al.   Nature Communications

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

(2012) Miguel A. Lanaspa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fructose metabolism in humans – what isotopic tracer studies tell us

(2012) Sam Z Sun et al.   Nutrition & Metabolism

Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Development of Fatty Liver

(2012) Miguel A. Lanaspa et al.   PLoS One

Functional roles of fructose

(2012) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice

(2012) T. Ishimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease

(2011) A. Brymora et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Radiopharmacological evaluation of 6-deoxy-6-[18F]fluoro-d-fructose as a radiotracer for PET imaging of GLUT5 in breast cancer

(2011) Melinda Wuest et al.   NUCLEAR MEDICINE AND BIOLOGY

Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucose

(2010) Virgile Lecoultre et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth

(2010) H. Liu et al.   CANCER RESEARCH

Fructose as a carbon source induces an aggressive phenotype in MDA-MB-468 breast tumor cells

(2010) Monzavi-Karbassi   INTERNATIONAL JOURNAL OF ONCOLOGY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measurement of glucose and fructose in clinical samples using gas chromatography/mass spectrometry

(2009) Paulin N. Wahjudi et al.   CLINICAL BIOCHEMISTRY

Ketohexokinase: Expression and Localization of the Principal Fructose-metabolizing Enzyme

(2009) Christine P. Diggle et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Direct Spectrophotometric Determination of Serum Fructose in Pancreatic Cancer Patients

(2009) Hongxiang Hui et al.   PANCREAS

Evidence for the Mitochondrial Lactate Oxidation Complex in Rat Neurons: Demonstration of an Essential Component of Brain Lactate Shuttles

(2008) Takeshi Hashimoto et al.   PLoS One