Article
Public, Environmental & Occupational Health
Rahul Patel, Jaspal S. Kooner, Weihua Zhang
Summary: Disparities in COVID-19 outcomes exist based on ethnicity and comorbidities. The study found that minority ethnic groups in the UK have poorer outcomes and a higher prevalence of certain comorbidities. The research also highlighted the lack of understanding regarding the relationship between psychiatric disorders and COVID-19 outcomes.
Review
Medicine, General & Internal
Eleonora Di Salvo, Mario Di Gioacchino, Alessandro Tonacci, Marco Casciaro, Sebastiano Gangemi
Summary: The role of alarmins in patients affected by COVID-19 disease and their relationship with commonly reported comorbidities are the focus of current research. There is limited literature on this specific topic, but preliminary evidence confirms the involvement of danger signals in amplifying the inflammatory reaction associated with SARS-CoV-2 infection.
ANNALS OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sefer Elezkurtaj, Selina Greuel, Jana Ihlow, Edward Georg Michaelis, Philip Bischoff, Catarina Alisa Kunze, Bruno Valentin Sinn, Manuela Gerhold, Kathrin Hauptmann, Barbara Ingold-Heppner, Florian Miller, Hermann Herbst, Victor Max Corman, Hubert Martin, Helena Radbruch, Frank L. Heppner, David Horst
Summary: The study conducted autopsies on 26 patients who died after SARS-CoV-2 infection and COVID-19, finding that septic shock and multi organ failure were the most common immediate causes of death, often due to suppurative pulmonary infection. Most patients had comorbidities such as hypertension, ischemic heart disease, and obesity. The majority of deaths were found to be directly related to COVID-19, with contributory implications of preexisting health conditions to the mechanism of death.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Akin Osibogun, Mobolanle Balogun, Akin Abayomi, Jide Idris, Yetunde Kuyinu, Oluwakemi Odukoya, Ololade Wright, Remi Adeseun, Bamidele Mutiu, Babatunde Saka, Nike Osa, Dayo Lajide, Ismael Abdus-Salam, Bodunrin Osikomaiya, Oluwatosin Onasanya, Bisola Adebayo, Yewande Oshodi, Sunday Adesola, Olu Adejumo, Olufemi Erinoso, Hussein Abdur-Razzaq, Abimbola Bowale, Kingsley Akinroye
Summary: Data on comorbidities and their impact on COVID-19 outcomes among African populations are scarce. This study from Nigeria identified hypertension, diabetes, renal disease, cancer, and HIV as comorbidities that predict death in COVID-19 patients. The study suggests the importance of public awareness, early detection, and tailored care for COVID-19 patients with comorbidities.
Article
Immunology
Mohammed Aldhaeefi, Zabreen Tahir, David J. Cote, Saef Izzy, Joseph El Khoury
Summary: Demographics and comorbidities, such as age over 70, chronic kidney disease, hypertension, hyperlipidemia, obesity, or coronary artery disease, are associated with persistent COVID-19 PCR positivity for more than 4 weeks. Therefore, age and the presence of co-morbidities should be considered when interpreting a positive COVID PCR test.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Virology
Priya Duggal, Tristan Penson, Hannah N. Manley, Candelaria Vergara, Rebecca M. Munday, Dylan Duchen, Elizabeth A. Linton, Amber Zurn, Jeanne C. Keruly, Shruti H. Mehta, David L. Thomas
Summary: Understanding and describing the symptoms of COVID-19 patients in community settings months after infection, it was found that nearly one-third of the individuals reported incomplete recovery, and a small percentage reported symptoms severe enough to affect daily activities. Those with post-acute sequelae were more likely to have a history of heart attack. Among those with long-term symptoms, men and women were equally represented, but only women reported symptoms that constrained daily activities, with a majority being caregivers. The types of symptoms varied, with many experiencing a deviation from prior COVID-19 health, such as reduced exercise ability, walking ability, concentration, or breathing.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Ann M. Navar, Stacey N. Purinton, Qingjiang Hou, Robert J. Taylor, Eric D. Peterson
Summary: Among hospitalized COVID-19 patients in the United States, there are racial and ethnic disparities in mortality rates, with Black adults showing higher mortality rates due to a higher burden of comorbidities. In contrast, Hispanic patients exhibit lower mortality rates even after adjusting for various demographic and clinical factors.
Article
Medicine, General & Internal
Nico Dragano, Olga Dortmann, Joerg Timm, Matthias Mohrmann, Rosemarie Wehner, Christoph J. Rupprecht, Maria Scheider, Ertan Mayatepek, Morten Wahrendorf
Summary: This population-based cohort study found that children from disadvantaged households have a higher risk of COVID-19 hospitalization. This highlights the need to pay attention to children from vulnerable families and consider closer monitoring. Although some explanatory factors were taken into account, no clear conclusion was drawn about the underlying processes.
Review
Immunology
Banafsheh Bigdelou, Mohammad Reza Sepand, Sahar Najafikhoshnoo, Jorge Alfonso Tavares Negrete, Mohammed Sharaf, Jim Q. Ho, Ian Sullivan, Prashant Chauhan, Manina Etter, Tala Shekarian, Olin Liang, Gregor Hutter, Rahim Esfandiarpour, Steven Zanganeh
Summary: The interactions between COVID-19 and co-existing diseases have significant implications for clinical outcomes. Co-existing diseases make patients more vulnerable to severe consequences from COVID-19, highlighting the importance of further research for the optimal management of patients with comorbidities.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Nikhita Gogate, Daniel Lyman, Amanda Bell, Edmund Cauley, Keith A. Crandall, Ashia Joseph, Robel Kahsay, Darren A. Natale, Lynn M. Schriml, Sabyasach Sen, Raja Mazumder
Summary: In response to the COVID-19 outbreak, scientists and medical researchers are exploring a wide range of host responses, symptoms, and lingering issues post-recovery in the human population. They have identified 145 potential COVID-19 biomarkers, most of which are related to immune or coagulation cascades, indicating a complex vascular pathobiology of the disease. Additionally, these biomarkers show commonality with established cancer biomarkers as well as biomarkers for metabolic syndrome and diabetes.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Infectious Diseases
Kanwal Raghav, Seerat Anand, Anirudh Gothwal, Pooja Singh, Arvind Dasari, Michael J. Overman, Jonathan M. Loree
Summary: Although racial/ethnic disparities in healthcare have long been recognized, recent discourse around structural racism will hopefully lead to improved transparency surrounding these issues. Despite the disproportionate impact of COVID-19 on racial/ethnic minorities, the extent and reliability of race reporting in COVID research is unclear. Research during the first wave of the pandemic lacked appropriate racial/ethnicity reporting, but mirrored COVID-19 incidence in the USA, highlighting the increased burden of infection among Black individuals.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Hematology
Lana Mucalo, Amanda M. Brandow, Mahua Dasgupta, Sadie F. Mason, Pippa M. Simpson, Ashima Singh, Bradley W. Taylor, Katherine J. Woods, Fouza Yusuf, Julie A. Panepinto
Summary: A history of pain and SCD heart/lung comorbidities were identified as risk factors for hospitalization in children, while a history of pain was a risk factor for hospitalization in adults. A history of pain was associated with an increased risk of developing serious COVID-19 illness in both children and adults.
Article
Public, Environmental & Occupational Health
Shaffi F. Koya, Shahul H. Ebrahim, Lekha D. Bhat, Bindhya Vijayan, Salman Khan, Soji D. Jose, Zarin Pilakkadavath, Premini Rajeev, Jinbert L. Azariah
Summary: This study aimed to describe the factors associated with COVID-19 deaths in the State of Tamil Nadu, India, and to compare deaths among COVID patients with and without comorbidities. The research found that young adults with comorbidities in India had shorter survival times from symptom onset to death, and hypothyroidism is a COVID-19 associated co-morbidity.
JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH
(2021)
Article
Multidisciplinary Sciences
Soo Ick Cho, Susie Yoon, Ho-Jin Lee
Summary: The study investigated the impact of comorbidity burden on mortality in patients with COVID-19, and found that hypertension, diabetes, and other diseases are significant risk factors for mortality. The results showed that age-adjusted CCI has high predictive power in mortality prediction.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Karel Kostev, Lee Smith, Ai Koyanagi, Marcel Konrad, Louis Jacob
Summary: The prevalence of post-COVID-19 condition was low in COVID-19 children and adolescents in Germany. Older children and adolescents were more likely to be diagnosed with post-COVID-19 condition. Anxiety disorders, somatoform disorders, and allergic rhinitis were significantly associated with post-COVID-19 condition.
PEDIATRIC RESEARCH
(2022)