Article
Microbiology
Vanessa Lang, Katrin Gunka, Jan Rudolf Ortlepp, Ortrud Zimmermann, Uwe Gross
Summary: Nosocomial infections with Clostridioides difficile have emerged as a serious health threat. This study aimed to identify risk factors for C. difficile infection beyond the well-known factors. It found that regular consumption of proton pump inhibitors, low vegetable intake, and the use of the diuretic agent torasemid were additional risk factors for CDI.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tadakuni Monma, Junichi Iwamoto, Akira Honda, Hajime Ueda, Fumio Kakizaki, Shoichiro Yara, Teruo Miyazaki, Tadashi Ikegami
Summary: The ratio of secondary bile acids in serum can serve as a biomarker for predicting susceptibility to Clostridium difficile infection, with levels below a certain threshold indicating a higher risk of CDI.
Article
Gastroenterology & Hepatology
Amiko M. Uchida, Gabrielle Ro, John J. Garber, Bjorn Roelstraete, Jonas F. Ludvigsson
Summary: Prior infection, particularly after sepsis and gastrointestinal or respiratory infections, is associated with the development of eosinophilic esophagitis (EoE).
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Environmental Sciences
Juan Li, Bin Wang, Shijian Liu, Yue Zhang, Chen Chen, Yihui Jin, Zhemin Shen, Tao Yuan, Xiaodan Yu
Summary: This study investigated the associations between urinary concentrations of multiple antibiotics and adiposity risk in school children, revealing a link between exposure to veterinary antibiotics and increased risk of adipogenesis in children, particularly in boys. Further studies are needed to confirm these findings and clarify the underlying mechanisms.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Surgery
Alexis Hess, Saskya Byerly, Emily Lenart, Cory Evans, Andrew Kerwin, Dina Filiberto
Summary: This study aimed to identify predictors of Clostridium Difficile Infection (CDI) in general surgery patients. Patients who underwent general surgery operations were analyzed, and it was found that older age, emergent operation, increased time to operation, infections at surgical sites, deep organ space infections, steroid use, metastatic cancer, smoking, and decreased body mass index (BMI) were independent predictors of CDI.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Immunology
Aaron C. Miller, Alan T. Arakkal, Daniel K. Sewell, Alberto M. Segre, Joseph Tholany, Philip M. Polgreen, CDC MInD Healthcare Grp
Summary: This study evaluated the risk of CDI (Clostridioides difficile infection) associated with different types of antibiotics using a large database. Results showed that clindamycin and later-generation cephalosporins had the highest risk, while minocycline and doxycycline had the lowest risk. These findings are important for informing antibiotic prescribing decisions and stewardship efforts.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Zhenxing Li, Qiao Wang, Jiahui Ma, Zhi Li, Dong Huang, Yuzhao Huang, Haocheng Zhou
Summary: The study found that CKD patients undergoing dialysis and immunosuppressant therapy are at greater risk of developing herpes zoster. It is recommended to consider zoster vaccination for these patients.
Article
Immunology
Yi-Ching Chen, Yi-Chun Kuo, Mi-Chi Chen, Young-Da Zhang, Chyi-Liang Chen, Puo-Hsien Le, Cheng-Hsun Chiu
Summary: This study identified vancomycin-resistant Clostridium innocuum as a pathogen causing antibiotic-associated diarrhea, with higher rates of complications and mortality compared to Clostridioides difficile infection. Chronic kidney disease, solid tumor, intensive care unit admission, and shock status were identified as independent risk factors for death in C. innocuum-infected patients. Precise identification and timely antimicrobial therapy are crucial due to the intrinsic vancomycin resistance of this pathogen.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Shanshan Shao, Weijun Pan, Baolin Wang, Yuwei Liu, Hong Gan, Mengdie Li, Tierong Liao, Xinliu Yang, Qianhui Yang, Cun Huang, Menglong Geng, Guixia Pan, Kaiyong Liu, Peng Zhu, Fangbiao Tao
Summary: A study found that women exposed to low-dose antibiotics have a higher risk of infertility, while the use of certain antibiotics can reduce the risk of infertility. These results suggest that the effects of antibiotics on female fertility vary based on the active ingredient and usage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Public, Environmental & Occupational Health
Diaa Alrahmany, Benjamin J. Ereshefsky, Wasim S. El Nekidy, Gehan Harb, Laura Pontiggia, Islam M. Ghazi
Summary: This study analyzed data from 204 patients with C. difficile infection and found that factors such as female gender, older age, prior exposure to clindamycin, concurrent use of aztreonam, and longer hospital stay were associated with the occurrence of rCDI. These risk factors could help identify patients who may benefit from closer monitoring and interventions to prevent rCDI and improve clinical outcomes.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Surgery
Elisa Morales-Marroquin, Luyu Xie, Madhuri Uppuluri, Jaime P. Almandoz, Nestor de la Cruz-Munoz, Sarah E. Messiah
Summary: The study found that patients using immunosuppressants after metabolic and bariatric surgery are at higher risk of developing Clostridioides difficile infection. Patients who underwent laparoscopic Roux-en-Y gastric bypass surgery had a higher odds of infection compared to those who underwent laparoscopic sleeve gastrectomy. Patients using immunosuppressants should be closely monitored both pre and post procedure.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Oncology
Tareq M. Haedenkamp, Michael F. Leitzmann, Ralf A. Linker, Christoph Meier, Claudia Becker, Susan Jick, Peter Hau, Corinna Seliger
Summary: This large case-control study investigated the association between antibiotic use and the risk of glioma. The results showed no significant increase in glioma risk after antibiotic use, and the use of polyenes may be weakly associated with a decreased risk of glioma.
Article
Clinical Neurology
Meisheng Wang, Deju Yin, Lijun Liu, Shuzhe Zhou, Qi Liu, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Wang, Qiaoling Chen, Gang Zhu, Xueyi Wang, Tianmei Si, Xin Yu, Xiaozhen Lv, Nan Zhang
Summary: This study found that cognitive impairment is common in patients with major depressive disorder, and it is associated with male sex and younger age of first onset, while comorbid anxiety disorders are protective against cognitive impairment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Jarl Emanuel Strange, Anders Holt, Paul Blanche, Gunnar Gislason, Christian-Torp-Pedersen, Daniel Molager Christensen, Morten Lock Hansen, Morten Lamberts, Morten Schou, Jonas Bjerring Olesen, Emil Loldrup Fosbol, Lars Kober, Peter Vibe Rasmussen
Summary: A nationwide nested case-control study in Denmark found no significant association between oral fluoroquinolones (FQs) and increased rates of valvular regurgitation, indicating a lack of evidence supporting a causal connection between FQ exposure and incident valvular regurgitation.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Jarl Emanuel Strange, Anders Holt, Paul Blanche, Gunnar Gislason, Christian-Torp-Pedersen, Daniel Molager Christensen, Morten Lock Hansen, Morten Lamberts, Morten Schou, Jonas Bjerring Olesen, Emil Loldrup Fosbol, Lars Kober, Peter Vibe Rasmussen
Summary: Using Danish administrative registers, a study found that oral fluoroquinolones are not significantly associated with an increased risk of valvular regurgitation.
EUROPEAN HEART JOURNAL
(2021)
Article
Dermatology
Maria Ilaria Del Principe, Danila Seidel, Marianna Criscuolo, Michelina Dargenio, Zdenek Racil, Monica Piedimonte, Francesco Marchesi, Gianpaolo Nadali, Philipp Koehler, Nicola Fracchiolla, Chiara Cattaneo, Nikolai Klimko, Angelica Spolzino, Deniz Yilmaz Karapinar, Hayati Demiraslan, Rafael F. Duarte, Judit Demeter, Marta Stanzani, Lorella Maria Antonia Melillo, Claudia Maria Basilico, Simone Cesaro, Giovangiacinto Paterno, Catello Califano, Mario Delia, Elisa Buzzatti, Alessandro Busca, Oliver A. Cornely, Livio Pagano, Nael Alakel, Valentina Arsi'c Arsenijevi'c, Vincent Camus, Iker Falces-Romero, Levy Itzhak, Michal Kouba, Rodrigo Martino, Petr Sedlacek, Barbora Weinbergerova
Summary: Our study aims to identify and provide therapeutic guidance for Magnusiomyces-associated infections, an emerging threat in patients with haematological malignancies. Neutrophil recovery appears to play a crucial role in the favorable outcome of these infections.
Review
Infectious Diseases
L. Haensel, J. Schumacher, B. Denis, S. Hamane, O. A. Cornely, P. Koehler
Summary: The incidence of Pneumocystis jirovecii pneumonia (PCP) is increasing in patients without HIV infection. Unlike PCP in HIV-infected patients, diagnosis is often delayed in non-HIV-infected patients and is associated with higher mortality. This comprehensive review provides information on clinical presentation, risk factors, diagnostic strategies, and treatment options for PCP in non-HIV-infected patients.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Oncology
Nicola Giesen, Elena Busch, Enrico Schalk, Gernot Beutel, Maria M. Ruethrich, Marcus Hentrich, Bernd Hertenstein, Hans H. Hirsch, Meinolf Karthaus, Yascha Khodamoradi, Philipp Koehler, William Kruger, Michael Koldehoff, Robert Krause, Sibylle C. Mellinghoff, Olaf Penack, Michael Sandherr, Ruth SeggeWiss-Bernhardt, Karsten Spiekermanny, Rosanne Sprute, Jannik Stemler, Florian Weissinger, Bernhard Woermann, Hans-Heinrich Wolf, Oliver A. Cornely, Christina T. Rieger, Marie von Lilienfeld-Toal
Summary: The novel coronavirus SARS-CoV-2 and associated infectious disease COVID-19 present a significant challenge to healthcare systems worldwide, with cancer patients being identified as a high-risk population. The rapid development of vaccines and therapeutic agents against COVID-19 offers new options for improving care and protection of cancer patients. However, ongoing epidemiological changes and the emergence of new virus variants require constant revisions and adaptations of prophylaxis and treatment strategies to address these new challenges.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Infectious Diseases
Sofie Schumacher, Jon Salmanton-Garcia, Andrea Liekweg, Muriel Rolfes, Danila Seidel, Sibylle C. Mellinghoff, Oliver A. Cornely
Summary: This study investigates the impact of an intensified influenza vaccination campaign in a maximum-care hospital on influenza vaccination coverage in healthcare workers during the COVID-19 pandemic in 2020/21. The campaign, which involved a mobile vaccination team and a central vaccination site, led to a significant increase in vaccination coverage among healthcare workers, especially among nurses.
Review
Infectious Diseases
Jannik Stemler, Sibylle C. Mellinghoff, Yascha Khodamoradi, Rosanne Sprute, Annika Y. Classen, Sonja E. Zapke, Martin Hoenigl, Robert Krause, Martin Schmidt-Hieber, Werner J. Heinz, Michael Klein, Philipp Koehler, Blasius Liss, Michael Koldehoff, Christoph Buhl, Olaf Penack, Georg Maschmeyer, Enrico Schalk, Cornelia Lass-Floerl, Meinolf Karthaus, Markus Ruhnke, Oliver A. Cornely, Daniel Teschner
Summary: Patients with haematological malignancies are at high risk of invasive fungal disease. The German Society of Haematology and Medical Oncology has updated their antifungal prophylaxis recommendations, recommending continued antifungal prophylaxis for patients with long-lasting neutropenia and posaconazole as the drug of choice. There is insufficient data to give general recommendations for antifungal prophylaxis in patients receiving novel treatments for HM, such as CAR-T-cell therapy or novel targeted therapies for AML.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Fernando Riera, Juan Pablo Caeiro, Oliver A. Cornely, Jon Salmanton-Garcia
Summary: Immunosuppressed patients, transplant recipients, and those with acute or chronic respiratory disease are at increased risk for invasive fungal infections in Argentina. Little is known about the quality of available diagnostic and treatment armamentaria for invasive fungal infections in the country, despite the national public system guaranteeing universal access to health care.
Article
Public, Environmental & Occupational Health
Vincent Lucansky, Marek Samec, Tatiana Burjanivova, Eva Lukacova, Zuzana Kolkova, Veronika Holubekova, Eva Turyova, Andrea Hornakova, Tibor Zaborsky, Petar Podlesniy, Lenka Reizigova, Zuzana Dankova, Elena Novakova, Renata Pecova, Andrea Calkovska, Erika Halasova
Summary: The study explores the use of waste-based epidemiology for early detection and monitoring of SARS-CoV-2 in wastewater samples. The results suggest that selecting the appropriate methods for isolation and detection can improve the sensitivity of testing. This non-invasive approach has the potential to serve as an early warning alert for public health.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Infectious Diseases
Gordon Brestrich, Frederick J. Angulo, Fabian K. Berger, Christian Broesamle, Stefan Hagel, Andreas Leischker, Christoph Luebbert, Friederike Maechler, Sophie-Susann Merbecks, Nadia Minarovic, Jennifer C. Moisi, Lutz von Mueller, Phillip A. Reuken, Thomas Weinke, Holly Yu, Alexander Mellmann
Summary: Clostridioides difficile infection (CDI) is a global threat, especially for vulnerable populations. This study analyzed data from four public databases to describe and compare the CDI burden in Germany. The results showed a decline in CDI cases since 2013, but the disease burden remains substantial and needs continued attention.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Food Science & Technology
Elena Novakova, Henrik A. Kildahl, Jana Kompanikova, Martina Neuschlova, Zuzana Stofkova
Summary: Foodborne illnesses are a significant health concern, and Norwegian fermented fish is a traditional method of preserving fish. Improper preparation or storage can lead to contamination with Clostridium botulinum, resulting in the production of neurotoxin. Hygiene practices, temperature, and salt concentration are important factors in preventing microbial growth and botulism. Botulism is rare but still relevant when discussing homemade fermented fish, and clinicians should consider it as a diagnostic clue.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2023)
Article
Infectious Diseases
Oliver A. Cornely, Helmut Ostermann, Philipp Koehler, Daniel Teschner, Endrik Limburg, William G. Kramer, Sara H. Barbat, Margaret Tawadrous, Michael R. Hodges
Summary: This study evaluated the tolerability, safety, and pharmacokinetics of Fosmanogepix in AML patients. The results showed that Fosmanogepix was safe and well tolerated in patients undergoing chemotherapy, and its safety and pharmacokinetic profiles were comparable to healthy volunteers.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Health Care Sciences & Services
Sibylle Mellinghoff, Gero von Gersdorff, Caroline Bruns, Kerstin Albus, Vassiliki Dimitriou, Angela Steinbach, Mathias Schaller, Jorg Janne Vehreschild, Oliver A. Cornely, Blasius Janusch Liss
Summary: This study aims to compare the pneumonia rates between recently vaccinated patients and patients vaccinated more than 2 years ago, and to determine the dynamics of antipneumococcal antibody titers in hemodialysis patients. The results will increase physician adherence to current recommendations and provide evidence for future guidelines.
JMIR RESEARCH PROTOCOLS
(2023)
Editorial Material
Health Care Sciences & Services
Rosanne Sprute, Seraina Duda, Andrea Liekweg, Michaela Simon, Oliver A. Cornely
LANCET REGIONAL HEALTH-EUROPE
(2023)
Review
Infectious Diseases
Jon Salmanton-Garcia, Martin Hoenigl, Jean-Pierre Gangneux, Esther Segal, Ana Alastruey-Izquierdo, Sevtap Arikan Akdagli, Katrien Lagrou, Volkan oezenci, Antonio Vena, Oliver A. Cornely
Summary: The diagnostic capacity for invasive fungal infections in Europe is generally good, but there are limitations in access to certain diagnostic tools and antifungal drugs. These limitations need to be addressed to ensure optimal diagnosis and treatment for all patients.
Article
Medicine, General & Internal
Jarmila Vojtkova, Peter Banovcin, Anna Durdikova, Elena Novakova, Milos Jesenak
Summary: The study aimed to investigate the association between moderate COVID-19 infection and hyperglycaemia. The results showed that COVID-19 patients had significantly higher average blood glucose levels compared to patients with other viral infections, especially those with gastrointestinal symptoms or fever. Therefore, COVID-19 infection is associated with an increased risk of hyperglycaemia.
MEDICINA-LITHUANIA
(2023)
Article
Virology
Tatiana Burjanivova, Eva Lukacova, Vincent Lucansky, Marek Samec, Petar Podlesniy, Zuzana Kolkova, Lenka Reizigova, Marian Grendar, Eva Turyova, Veronika Holubekova, Bibiana Malicherova, Vladimir Nosal, Ivana Kasubova, Robert Dusenka, Denisa Osinova, Jana Hosalova Matisova, Dana Dvorska, Dusan Brany, Zuzana Dankova, Elena Novakova, Andrea Calkovska, Erika Halasova
Summary: Monitoring SARS-CoV-2 in air traffic is crucial to prevent the virus from spreading globally. We developed sensitive detection methods, ddPCR and RT-qPCR, for early and accurate detection of SARS-CoV-2. Analysis of patient samples showed higher positivity with ddPCR compared to RT-qPCR. We also identified a positive sample using ddPCR from saliva samples of passengers and airport staff. Our findings demonstrate the advantages of saliva collection and the suitability of ddPCR for virus detection.