期刊
ACS OMEGA
卷 5, 期 24, 页码 14437-14443出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.0c01010
关键词
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资金
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions [PPZY2015B146]
- Scientific Research Foundation of Wuxi City for the Returned Overseas Chinese Scholars
- 2018 Innovative Research Team of Jiangsu Province
Graphene oxide (GO) has been studied by many researchers for its potential drug-delivery value. In order to reduce the side effects of anticancer drugs by decreasing the dosage and maintain the therapeutic effects, a dual drug-delivery system that used GO as a carrier and simultaneously loaded with antitumor drugs and antimir-21 was rationally designed for the cooperative treatment of tumors. Results obtained from our studies have found that MDA-MB-231 cells were inhibited in low Dox dose. The outcomes of confocal microscopy indicated that Dox and antimiR-21 could be released rapidly in cancer cells, which is good for killing cancer cells. In addition, qRT-PCR further demonstrated that miR-21 was silenced by antimiR-21. Consequently, GO has a great potential to codeliver chemotherapeutic drugs and gene drugs in cancer combination therapy for reducing toxicity.
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