期刊
ACS OMEGA
卷 5, 期 28, 页码 17839-17849出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.0c02759
关键词
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资金
- National Key R&D Program of China [2017YFE0102200]
- National Natural Science Foundation of China [31872067]
- 111 Project [B17039]
- Fundamental Research Funds for the Central Universities
The present study is to investigate the polyphenolic composition and in vivo antidiabetic effect of white-fleshed Chinese bayberry cultivar Shui Jing. By liquid chromatography quadrupole time-of-flight mass spectrometry (LC-TOF- MS), 38 polyphenols were identified in the Shui Jing fruit extract (SJE), where proanthocyanidins (PAs), including epigallocatechin gallate (EGCG), as well as flavonols, including myricitrin and quercetrin, were the predominant ingredients. After a 5-week experiment, the SJE (200 mg/kg bodyweight) significantly reduced fasting blood glucose, elevated glucose tolerance, and insulin sensitivity in diabetic KK-A(y) mice. It markedly attenuated bodyweight gain and decreased glycolipid metabolism-related markers including insulin, leptin, glucagon, triglyceride (TG), total cholesterol (TC), lowdensity lipoprotein cholesterol (LDL-c) and alanine aminotransferase (ALT) levels in mice. Liver weight and hepatic lipid accumulation were also significantly reduced by the SJE. Gene expressions of insulin 1 (INS1) and glycogen synthase kinase 3 beta (GSK3b) were markedly inhibited while the hepatic phosphorylation of AMPK alpha was significantly increased in the liver of SJE-treated mice, indicating that the SJE may exert an antidiabetic effect through an AMPK-dependent pathway. In conclusion, white bayberry rich in PAs and flavonols may have great potential in the regulation of diabetes mellitus.
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