Article
Medicine, General & Internal
Thomas Senoner, Robert Breitkopf, Benedikt Treml, Sasa Rajsic
Summary: Invasive fungal infections are a major challenge in organ transplant patients, with candidiasis being the most common, followed by aspergillosis and cryptococcosis. Liver transplant recipients are at high risk for candidiasis and aspergillosis, and targeted prophylaxis is recommended. Timely treatment is crucial for optimal outcomes in transplanted patients. This article provides an overview of the epidemiology, risk factors, prophylaxis, and treatment strategies for the most common fungal infections in organ transplantation, focusing on liver transplantation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Christopher M. Rubino, Shawn Flanagan
Summary: A population pharmacokinetic model was developed to characterize the disposition of rezafungin in plasma following IV administration, showing significant relationships between subject descriptors and rezafungin PK parameters. The final model provided a precise and unbiased fit to observed concentrations and can reliably predict rezafungin PK in infected patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Engineering, Biomedical
Tao Huang, Xin Li, Michael Maier, Neil M. O'Brien-Simpson, Daniel E. Heath, Andrea J. O'Connor
Summary: Fungal infections pose a serious threat to human health and the limited number of clinically approved antifungal drugs, as well as the emergence of drug resistance, increase the impact of fungal infections. However, fungal infections receive less attention compared to bacterial infections.
ACTA BIOMATERIALIA
(2023)
Review
Pharmacology & Pharmacy
Sweety Dahiya, Namita Sharma, Aruna Punia, Pooja Choudhary, Prity Gulia, Virinder S. Parmar, Anil K. Chhillar
Summary: Fungal infections have been on the rise in recent decades, primarily due to the increase in immunocompromised patients. Invasive candidiasis is more common than invasive aspergillosis, with a mortality rate of around 45%. Ineffective diagnostic techniques and inappropriate initial treatment strategies contribute to this high mortality. There are only a few classes of antifungal drugs available for the treatment of invasive fungal infections, and the use of these drugs has increased significantly in the last few decades. However, this has also led to an increase in antifungal drug resistance, particularly to azoles. The emergence of antifungal drug resistance has resulted in reduced treatment success rates and major changes in the frequency of fungal infections.
CURRENT DRUG TARGETS
(2022)
Article
Microbiology
Andreas Enz, Silke C. Mueller, Philipp Warnke, Martin Ellenrieder, Wolfram Mittelmeier, Annett Klinder
Summary: The treatment of fungal periprosthetic joint infections presents a special challenge in orthopaedic surgery, with mixed infections of bacteria and Candida albicans being common. The complexity and difficulty of treating fungal infections in joint revisions are highlighted in this study.
Article
Medicine, General & Internal
Robert Breitkopf, Benedikt Treml, Katharina Simmet, Zoran Bukumiric, Margot Fodor, Thomas Senoner, Sasa Rajsic
Summary: Invasive fungal infections (IFIs) are a significant risk after liver transplantation, and the use of antifungal prophylaxis is common. This study aimed to investigate the incidence of IFIs under targeted echinocandin prophylaxis in high-risk liver transplant recipients. The results showed that despite prophylaxis, there was still a notable risk for IFIs, especially in patients with certain risk factors. It is important to critically evaluate the use of echinocandins for prophylaxis and adhere to internal prophylaxis algorithms to minimize the risk of IFIs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Robert Breitkopf, Benedikt Treml, Thomas Senoner, Zoran Bukumiric, Sasa Rajsic
Summary: Invasive fungal infections are common complications after liver transplantation, and the choice of antifungal agent for prophylaxis is still a topic of debate. Recent data suggest concerns about the efficacy of echinocandins in preventing breakthrough infections, particularly in cases of intra-abdominal candidiasis. A retrospective study on high-risk liver transplant recipients receiving echinocandin prophylaxis showed a breakthrough incidence of 16%, which had significant effects on postoperative complications, graft survival, and mortality. The reasons for the breakthrough infections may be multifactorial, including the emergence of Candida parapsilosis and the development of echinocandin resistance in Candida glabrata. Further studies are needed to clarify the efficacy of echinocandin prophylaxis in liver transplantation.
Review
Microbiology
Jeffrey M. Rybak, Christina A. Cuomo, P. David Rogers
Summary: Fungal infections cause significant health problems, and the resistance to antifungal drugs poses a threat to public health. Some pathogenic fungi display resistance to major antifungal drugs. This article provides an overview of the current knowledge on the molecular and genetic basis for antifungal resistance in this fungal pathogen.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Maria-Ioanna Beredaki, Maiken C. Arendrup, David Andes, Joseph Meletiadis
Summary: By developing a novel in vitro dialysis-diffusion PK/PD model, the pharmacodynamics of micafungin against Candida albicans were studied. The study supports the EUCAST breakpoints but questions the appropriateness of the current CLSI breakpoint.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Na Liu, Jie Tu, Yahui Huang, Wanzhen Yang, Qingwen Wang, Zhuang Li, Chunquan Sheng
Summary: Invasive fungal infections (IFIs) are a serious public health threat with high incidence and mortality, especially in cancer patients undergoing chemotherapy. However, the limited availability of effective and safe antifungal agents, coupled with the development of drug resistance, hinders successful antifungal therapy. Therefore, new antifungal agents with novel modes of action, favorable pharmacokinetic profiles, and anti-resistance activity are urgently needed. This review summarizes new antifungal targets, target-based inhibitor design, and prodrug design strategies to improve the physicochemical and pharmacokinetic properties of antifungal agents. Dual-targeting antifungal agents offer a promising strategy for the treatment of resistant infections and cancer-associated fungal infections.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Infectious Diseases
Farnaz Daneshnia, Amir Arastehfar, Lisa Lombardi, Ulrike Binder, Jakob Scheler, Roya Vahedi Shahandashti, Ferry Hagen, Cornelia Lass-Floerl, Michael K. Mansour, Geraldine Butler, David S. Perlin
Summary: Candida parapsilosis is a significant cause of candidemia worldwide. Mutations in the FKS1 gene outside the hotspot regions can result in a higher level of echinocandin tolerance, potentially leading to the development of echinocandin resistance. This study supports the cataloging of these mutations for better understanding and management of Candida parapsilosis infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Biochemistry & Molecular Biology
Alexander Bruch, Abdulrahman A. Kelani, Matthew G. Blango
Summary: In recent years, RNA-based therapeutics have gained attention as a potential treatment for genetic disorders and infectious diseases. However, the potential of RNA-based therapeutics to treat human fungal infections has been overlooked, despite the significant mortality caused by these infections.
TRENDS IN MICROBIOLOGY
(2022)
Review
Immunology
Liu Cong, Chaoqun Chen, Shanshan Mao, Zibing Han, Zuobin Zhu, Ying Li
Summary: The morbidity and mortality of invasive fungal infections are increasing gradually, as fungi have developed stronger defense capabilities and resistance to antibiotics. Developing new drugs and strategies to combat these fungi is crucial. Recent research has shown that certain probiotics and intestinal bacteria can inhibit the invasion and colonization of fungi, providing new strategies for resisting invasive fungal infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Javier Fernandez, Salvatore Piano, Michele Bartoletti, Emmanuel Q. Wey
Summary: Bacterial infections are common in cirrhotic patients with acute decompensation or acute-on-chronic liver failure, while fungal infections are less common but associated with high short-term mortality. Early diagnosis and appropriate empirical treatment are crucial in managing these patients. Combatting antibiotic resistance and adopting more complex treatment strategies are essential in the current management of cirrhotic patients.
JOURNAL OF HEPATOLOGY
(2021)
Article
Immunology
Samuel P. Simon, Rosanna Li, Michael Silver, Justin Andrade, Biju Tharian, Lung Fu, Diana Villanueva, Daniel Gonzalez Abascal, Ariel Mayer, James Truong, Nilka Figueroa, Monica Ghitan, Edward Chapnick, Yu Shia Lin
Summary: This study compared the clinical characteristics and outcomes between patients with bloodstream infections caused by Candida auris and those caused by other Candida spp. The study found that patients with C. auris candidemia did not have a higher mortality risk compared to those with candidemia caused by other Candida spp., but they had a higher risk of microbiologic recurrence within 60 days after completion of antifungal therapy.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Urszula Nawrot, Ewelina Kurzyk, Maiken Cavling Arendrup, Martyna Mroczynska, Katarzyna Wlodarczyk, Beata Sulik-Tyszka, Marta Wroblewska, Marek Ussowicz, Przemyslaw Zdziarski, Kinga Niewinska, Anna Brillowska-Dabrowska
Article
Biochemistry & Molecular Biology
Martyna Mroczynska, Anna Brillowska-Dabrowska
ACTA BIOCHIMICA POLONICA
(2019)
Article
Microbiology
Martyna Mroczynska, Ewelina Kurzyk, Magdalena Sliwka-Kaszynska, Urszula Nawrot, Marta Adamik, Anna Brillowska-Dabrowska
Article
Microbiology
Martyna Mroczynska, Anna Brillowska-Dabrowska
Summary: This study revealed that the factors enabling Candida spp. infections are related to the expression of proteases, hemolysins, and esterases, and some isolates display high virulence while others are avirulent or of low virulence.
Article
Chemistry, Physical
Magdalena Sliwka-Kaszynska, Marek Slebioda, Anna Brillowska-Dabrowska, Martyna Mroczynska, Jakub Karczewski, Anna Marzec, Przemyslaw Rybinski, Anna Drazkowska
Summary: The study conducted spectroscopic, spectrometric, and microbial investigations on funeral textiles from 17th and 18th century crypts, identifying dye sources and types through DNA analysis. By optimizing extraction methods and using various instruments, the study was able to confirm the origins of 34 colorants in historical textiles, including some previously unknown and uncommon dyes.
Article
Chemistry, Physical
Pawel Szarlej, Iga Carayon, Przemyslaw Gnatowski, Marta Glinka, Martyna Mroczynska, Anna Brillowska-Dabrowska, Justyna Kucinska-Lipka
Summary: This study focuses on the potential application of flexible thermoplastic polyurethane (TPU) and poly(lactic acid) (PLA) compositions in the production of antibacterial wound dressings using 3D printing. Through characterization and modification of different TPU/PLA compositions, a promising composition (COMP-7,5PLA) was selected for antibacterial modification. The study also compared two methods for antibacterial modification, with post-processing modification (AMI-1) showing superior antimicrobial activity against various bacteria strains.
Article
Biochemistry & Molecular Biology
Urszula Nawrot, Beata Sulik-Tyszka, Ewelina Kurzyk, Martyna Mroczynska, Katarzyna Wlodarczyk, Marta Wroblewska, Grzegorz Wladyslaw Basak, Anna Brillowska-Dabrowska
ACTA BIOCHIMICA POLONICA
(2017)
Article
Biochemistry & Molecular Biology
Anna Brillowska-Dabrowska, Martyna Mroczynska, Urszula Nawrot, Katarzyna Wlodarczyk, Ewelina Kurzyk
ACTA BIOCHIMICA POLONICA
(2015)
