Article
Multidisciplinary Sciences
Hiroaki Tanaka, Junichi Hasegawa, Shinji Katsuragi, Kayo Tanaka, Tatsuya Arakaki, Masamitsu Nakamura, Eijiro Hayata, Masahiko Nakata, Takeshi Murakoshi, Akihiko Sekizawa, Isamu Ishiwata, Tomoaki Ikeda
Summary: This study investigates the relationship between maternal mortality and advanced maternal age in Japan, revealing significantly higher mortality rates in women over 40 years. The most common cause of death in this age group was hemorrhagic stroke, with more than half of these cases being associated with preeclampsia. These findings highlight the importance of considering these risks for older pregnant women and healthcare providers involved in their care.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Jiangheng Li, Jingli Yan, Linghua Ma, Yongquan Huang, Maoling Zhu, Wu Jiang
Summary: The study found that the prevalence of gestational diabetes mellitus (GDM) and advanced maternal age (AMA, >= 35 years) is increasing worldwide. This study evaluated the risks of pregnancy outcomes among younger and older women with GDM and analyzed the epidemiological interaction between GDM and AMA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Lin Lu, Jian-Hua Li, Xiao-Feng Dai, Juan-Bing Wei, Li-Hong Chen, Ji-Fen Hu
Summary: This study investigated the influence of advanced maternal age on the maternal and neonatal outcomes of preterm pregnancies. The results showed that advanced maternal age was associated with a higher risk of complications such as iatrogenic preterm birth, placenta previa, preeclampsia, gestational diabetes mellitus, and postpartum hemorrhage, but a lower risk of multiple gestation. In terms of neonatal outcomes, the association between advanced maternal age and low birth weight or hyperbilirubinemia varied depending on the adjustment for multiple gestation.
GINEKOLOGIA POLSKA
(2022)
Article
Endocrinology & Metabolism
Bin Yu, Fang Guo, Yuqi Yang, Wei Long, Jun Zhou
Summary: This study discovered the profiles of different steroid hormones at the maternal-fetal interface and revealed the change characteristics in pregnant women at advanced maternal age (AMA). High androgen levels in AMA women have a positive relationship with adverse pregnancy complications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Samantha G. Bromfield, Qinli Ma, Andrea DeVries, Tiffany Inglis, Aliza S. Gordon
Summary: This study evaluated the association between hypertensive disorders during pregnancy and adverse outcomes for neonates and mothers. It also identified risk factors for the progression of milder hypertensive disorders to more severe conditions. The findings showed that mothers and neonates with preeclampsia or superimposed preeclampsia had higher risks of adverse outcomes compared to those without hypertension.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Biochemistry & Molecular Biology
Amy L. Wooldridge, Christy Chan, Floor Spaans, Anita Quon, Craig D. Steinback, Margie H. Davenport, Sandra T. Davidge, Christy-Lynn M. Cooke
Summary: Advanced maternal age is a risk factor for poor pregnancy outcomes, and it may affect the structure of resistance arteries in the omentum. This study found that omental arteries from women of advanced maternal age had lower compliance and less elastin compared to younger women. The collagen:elastin ratio was also higher in arteries from advanced maternal age women. These findings contribute to the understanding of how vascular aging affects pregnancy adaptations and may help improve pregnancy outcomes.
BIOSCIENCE REPORTS
(2023)
Article
Health Care Sciences & Services
Junjun Chen, Yuelong Ji, Tao Su, Ma Jin, Zhichao Yuan, Yuanzhou Peng, Shuang Zhou, Heling Bao, Shusheng Luo, Hui Wang, Jue Liu, Na Han, Hai-Jun Wang
Summary: Prediction models developed through machine learning statistics can help identify high-risk patients with de novo hypertensive disorder of pregnancy, enabling timely intervention and care.
Article
Endocrinology & Metabolism
Claire L. Meek, Zoe A. Stewart, Denice S. Feig, Samuel Furse, Sandra L. Neoh, Albert Koulman, Helen R. Murphy
Summary: This study found that maternal hyperglycemia and offspring hyperinsulinism in women with type 1 diabetes during pregnancy are associated with perinatal complications and suboptimal pregnancy outcomes. Metabolomic analysis revealed distinct metabolite profiles for different complications, such as increased carnitines and lipid metabolites in large for gestational age infants, and changes in triacylglycerols or dietary phenols in neonatal hypoglycemia and offspring hyperinsulinism. Altered lipid metabolism is a key feature in type 1 diabetes pregnancy, suggesting the need for new strategies to optimize maternal diet and insulin dosing from the first trimester.
Article
Obstetrics & Gynecology
Alexander P. Frick
Summary: Advanced maternal age is associated with a wide range of adverse pregnancy outcomes, including increased risks for miscarriage, chromosomal abnormalities, stillbirth, and preterm birth. However, varying definitions in both maternal age and reported outcomes can make it difficult to provide accurate counseling to individual women about their specific risks. It is important to clarify the magnitude of these risks in order to provide more informed clinical counseling and decision-making for pregnant women of advanced maternal age.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Endocrinology & Metabolism
Kirsten Neal, Shahid Ullah, Sarah J. Glastras
Summary: Obesity class is associated with an increased risk of adverse maternal and neonatal outcomes, with higher class obesity showing a stronger impact. Obesity class independently affects the incidence of large-for-gestational age (LGA) in newborns, regardless of factors such as gestational diabetes mellitus (GDM). It is crucial to continue efforts to reduce obesity among women of reproductive age to prevent the negative perinatal outcomes associated with obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Ethan K. Gough, Thaddeus J. Edens, Hyun Min Geum, Iman Baharmand, Sandeep K. Gill, Ruairi C. Robertson, Kuda Mutasa, Robert Ntozini, Laura E. Smith, Bernard Chasekwa, Florence D. Majo, Naume Tavengwa, Batsirai Mutasa, Freddy Francis, Lynnea Carr, Joice Tome, Rebecca J. Stoltzfus, Lawrence H. Moulton, Andrew J. Prendergast, Jean H. Humphrey, Amee R. Manges
Summary: The study in rural Zimbabwe found that the maternal intestinal microbiome composition and functions during pregnancy are closely related to infant birth weight and growth outcomes, with resistant starch-degrading bacteria playing a key role in predicting birth outcomes.
Article
Endocrinology & Metabolism
Turki Abdullah AlMogbel, Glynis Ross, Ted Wu, Lynda Molyneaux, Maria Ines Constantino, Margaret McGill, Anna Jane Harding, Christine Pech, Abdullah A. Alrasheed, Jencia Wong
Summary: The study found that exposure to Ramadan had no significant impact on maternal and neonatal outcomes, but longer exposure and exposure in later trimesters were associated with increased risk of neonatal hyperbilirubinemia. Conversely, longer exposure and exposure in late trimesters were associated with a lower prevalence of neonatal hypoglycemia. Additionally, fasting for a period of more than 15 hours was found to decrease the occurrence of neonatal hypoglycemia.
ACTA DIABETOLOGICA
(2022)
Review
Pediatrics
Xiaoqing Wu, Huifeng Gu, Junlin Wang
Summary: This meta-analysis reveals that hypertensive disorders of pregnancy increase the risk of preterm birth, cesarean sections, low birth weight, small for gestational age, and neonatal intensive care unit admissions in twin gestations. However, it reduces the risk of neonatal death.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Itamar Gilboa, Michael Kupferminc, Anat Schwartz, Yisca Landsberg Ashereh, Yariv Yogev, Avital Rappaport Skornik, Chagit Klieger, Liran Hiersch, Eli Rimon
Summary: This retrospective cohort study found an association between advanced maternal age and the clinical manifestations and laboratory parameters of preeclampsia with severe features. Older maternal age was found to be a risk factor for acute kidney injury and new-onset postpartum preeclampsia, but was associated with a reduced risk of HELLP syndrome and thrombocytopenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
Luoyuan Cao, Wenxu Dong, Qinjuan Wu, Xiaomin Huang, Xiaomei Zeng, Jing Yang, Jiaojiao Lu, Xunyan Chen, Xian Zheng, Xianguo Fu
Summary: The study aimed to assess chromosomal abnormalities and pathogenic CNVs in women of advanced maternal age (AMA) and assist with genetic counseling. It found that the detection rate of abnormal CNVs was higher in non-isolated AMA cases compared to isolated AMA cases, and pathogenic CNVs affected the rate of pregnancy termination in women with AMA.
FRONTIERS IN GENETICS
(2023)