The Implication of Gut Hormones in the Regulation of Energy Homeostasis and Their Role in the Pathophysiology of Obesity

Weight loss in patients with type 2 diabetes receiving once‐weekly dulaglutide plus insulin lispro or insulin glargine plus insulin lispro: A post‐hoc analysis of the AWARD‐4 study across baseline body mass index subgroups

(2019) Martin Fuechtenbusch et al.   DIABETES OBESITY & METABOLISM

PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes

(2019) Vanita R. Aroda et al.   DIABETES CARE

Remission of Type 2 Diabetes Mellitus after Bariatric Surgery: Fact or Fiction?

(2019) Dimitrios Tsilingiris et al.   International Journal of Environmental Research and Public Health

Will medications that mimic gut hormones or target their receptors eventually replace bariatric surgery?

(2019) Alexander Kokkinos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2020

(2019)   DIABETES CARE

Circulating levels of gastrointestinal hormones in response to the most common types of bariatric surgery and predictive value for weight loss over one year: Evidence from two independent trials

(2019) Nikolaos Perakakis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Important Considerations for the Treatment of Patients with Diabetes Mellitus and Heart Failure from a Diabetologist’s Perspective: Lessons Learned from Cardiovascular Outcome Trials

(2019) Chrysi Koliaki et al.   International Journal of Environmental Research and Public Health

Obesity, body weight regulation and the brain: insights from fMRI

(2018) Janine M Makaronidis et al.   BRITISH JOURNAL OF RADIOLOGY

Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials

(2018) Bo Ahrén et al.   DIABETES OBESITY & METABOLISM

Incretin hormones: Their role in health and disease

(2018) Michael A. Nauck et al.   DIABETES OBESITY & METABOLISM

Investigation of the long-term sustainability of changes in appetite after weight loss

(2018) S Nymo et al.   INTERNATIONAL JOURNAL OF OBESITY

MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study

(2018) Philip Ambery et al.   LANCET

Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery

(2018) Geoffrey P. Roberts et al.   Surgery for Obesity and Related Diseases

A novel dual glucagon-like peptide and glucagon receptor agonist SAR425899: Results of randomized, placebo-controlled first-in-human and first-in-patient trials

(2018) Joachim Tillner et al.   DIABETES OBESITY & METABOLISM

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation

(2018) Yongguo Li et al.   CELL

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

(2018) Juan Pablo Frias et al.   LANCET

Pharmacotherapy of obesity: Available medications and drugs under investigation

(2018) Eleni Pilitsi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Obesity and cardiovascular disease: revisiting an old relationship

(2018) Chrysi Koliaki et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial

(2018) Cara B Ebbeling et al.   BMJ-British Medical Journal

The Importance of the Gastrointestinal Tract in Controlling Food Intake and Regulating Energy Balance

(2017) Mariana P. Monteiro et al.   GASTROENTEROLOGY

The Role of Gut Hormones in Diet-Induced Weight Change: A Systematic Review

(2017) Xue Zhao et al.   HORMONE AND METABOLIC RESEARCH

The Effect of a Subcutaneous Infusion of GLP-1, OXM, and PYY on Energy Intake and Expenditure in Obese Volunteers

(2017) Tricia Tan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

(2017) Søren B. van Witteloostuijn et al.   JOURNAL OF PEPTIDE SCIENCE

Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior

(2017) Elizabeth G. Mietlicki-Baase et al.   NEUROPHARMACOLOGY

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Low Circulating Levels of Neurotensin in Women with Nonalcoholic Fatty Liver Disease Associated with Severe Obesity

(2017) Teresa Auguet et al.   Obesity

A Ketone Ester Drink Lowers Human Ghrelin and Appetite

(2017) Brianna J. Stubbs et al.   Obesity

Immunohistochemical Staining for Uroguanylin, a Satiety Hormone, is Decreased in Intestinal Tissue Specimens From Female Adolescents With Obesity

(2017) Matthew D Di Guglielmo et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Ghrelin, CCK, GLP-1, and PYY(3–36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB

(2017) Robert E. Steinert et al.   PHYSIOLOGICAL REVIEWS

The role of bariatric surgery to treat diabetes: current challenges and perspectives

(2017) Chrysi Koliaki et al.   BMC Endocrine Disorders

Decreased serum glicentin concentration in patients with severe and morbid obesity

(2017) Juliette Raffort et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals

(2017) Bettina K. Wölnerhanssen et al.   Scientific Reports

Reported appetite, taste and smell changes following Roux-en-Y gastric bypass and sleeve gastrectomy: Effect of gender, type 2 diabetes and relationship to post-operative weight loss

(2016) Janine M. Makaronidis et al.   APPETITE

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism

(2016) Kaare V. Grunddal et al.   ENDOCRINOLOGY

Potential Mechanisms Mediating Sustained Weight Loss Following Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

(2016) Janine M. Makaronidis et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3–36

(2016) Eva W Iepsen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

GhrelinO-acyltransferase (GOAT), a specific enzyme that modifies ghrelin with a medium-chain fatty acid

(2016) Masayasu Kojima et al.   JOURNAL OF BIOCHEMISTRY

Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes

(2016) Hannes Manell et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota

(2016) Alok Kumar Mishra et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Fasting Circulating Glicentin Increases After Bariatric Surgery

(2016) Juliette Raffort et al.   OBESITY SURGERY

Effect of Laparoscopic Sleeve Gastrectomy on Fasting Gastrointestinal, Pancreatic, and Adipose-Derived Hormones and on Non-Esterified Fatty Acids

(2016) John E. Farey et al.   OBESITY SURGERY

Reappraisal of GIP Pharmacology for Metabolic Diseases

(2016) Brian Finan et al.   TRENDS IN MOLECULAR MEDICINE

Uroguanylin levels in intestine and plasma are regulated by nutritional status in a leptin-dependent manner

(2015) C. Folgueira et al.   EUROPEAN JOURNAL OF NUTRITION

Altered gut and adipose tissue hormones in overweight and obese individuals: cause or consequence?

(2015) M E J Lean et al.   INTERNATIONAL JOURNAL OF OBESITY

Enteroendocrine cells: a review of their role in brain-gut communication

(2015) R. Latorre et al.   NEUROGASTROENTEROLOGY AND MOTILITY

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management

(2015) Xavier Pi-Sunyer et al.   NEW ENGLAND JOURNAL OF MEDICINE

GLP-1: A Mediator of the Beneficial Metabolic Effects of Bariatric Surgery?

(2015) Sean Manning et al.   PHYSIOLOGY

Food preferences and underlying mechanisms after bariatric surgery

(2015) Preeshila Behary et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Effects of PYY3–36 and GLP-1 on energy intake, energy expenditure, and appetite in overweight men

(2014) Julie Berg Schmidt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Simultaneous quantification of the glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK) receptor agonists in rodent plasma by on-line solid phase extraction and LC–MS/MS

(2014) Yan Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

20 YEARS OF LEPTIN: Role of leptin in energy homeostasis in humans

(2014) Michael Rosenbaum et al.   JOURNAL OF ENDOCRINOLOGY

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

(2014) Brian Finan et al.   NATURE MEDICINE

The Role of Gut Hormone Peptide YY in Energy and Glucose Homeostasis: Twelve Years On

(2013) Sean Manning et al.   Annual Review of Physiology

A PEGylated analog of the gut hormone oxyntomodulin with long-lasting antihyperglycemic, insulinotropic and anorexigenic activity

(2013) Elisabetta Bianchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications

(2013) S. Madsbad   DIABETES OBESITY & METABOLISM

Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass

(2013) C Dirksen et al.   INTERNATIONAL JOURNAL OF OBESITY

Differential Effects of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Bypass on Appetite, Circulating Acyl-ghrelin, Peptide YY3-36 and Active GLP-1 Levels in Non-diabetic Humans

(2013) Ahmed Yousseif et al.   OBESITY SURGERY

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

Cholecystokinin

(2013) Graham J. Dockray   Current Opinion in Endocrinology Diabetes and Obesity

Action and therapeutic potential of oxyntomodulin

(2013) Alessandro Pocai   Molecular Metabolism

The future role of gut hormones in the treatment of obesity

(2013) Rachel C. Troke et al.   Therapeutic Advances in Chronic Disease

Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men

(2012) Ixchel M. Brennan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Appetite, gut hormone and energy intake responses to low volume sprint interval and traditional endurance exercise

(2012) Kevin Deighton et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Gastric vagal afferent modulation by leptin is influenced by food intake status

(2012) Stephen J. Kentish et al.   JOURNAL OF PHYSIOLOGY-LONDON

Metabolic and Hormonal Changes After Laparoscopic Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: a Randomized, Prospective Trial

(2012) Ralph Peterli et al.   OBESITY SURGERY

The Gut Hormones PYY3-36 and GLP-17-36 amide Reduce Food Intake and Modulate Brain Activity in Appetite Centers in Humans

(2011) Akila De Silva et al.   Cell Metabolism

Metabolic and hedonic drives in the neural control of appetite: who is the boss?

(2011) Hans-Rudolf Berthoud   CURRENT OPINION IN NEUROBIOLOGY

Differential Acylated Ghrelin, Peptide YY3–36, Appetite, and Food Intake Responses to Equivalent Energy Deficits Created by Exercise and Food Restriction

(2011) James A. King et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Health and economic burden of the projected obesity trends in the USA and the UK

(2011) Y Claire Wang et al.   LANCET

Long-Term Persistence of Hormonal Adaptations to Weight Loss

(2011) Priya Sumithran et al.   NEW ENGLAND JOURNAL OF MEDICINE

The impact of extended care on the long-term maintenance of weight loss: a systematic review and meta-analysis

(2011) K. M. Ross Middleton et al.   Obesity Reviews

PYY3-36 and Oxyntomodulin Can Be Additive in Their Effect on Food Intake in Overweight and Obese Humans

(2010) B. C. T. Field et al.   DIABETES

Glucose-Dependent Insulinotropic Polypeptide May Enhance Fatty Acid Re-esterification in Subcutaneous Abdominal Adipose Tissue in Lean Humans

(2010) M. Asmar et al.   DIABETES

Weight Regain after a Diet-Induced Loss Is Predicted by Higher Baseline Leptin and Lower Ghrelin Plasma Levels

(2010) Ana B. Crujeiras et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bowels control brain: gut hormones and obesity

(2010) Benjamin C. T. Field et al.   Nature Reviews Endocrinology

Superior Appetite Hormone Profile After Equivalent Weight Loss by Gastric Bypass Compared to Gastric Banding

(2010) Mousumi Bose et al.   Obesity

Central amylin acts as an adiposity signal to control body weight and energy expenditure

(2010) Peter Y. Wielinga et al.   PHYSIOLOGY & BEHAVIOR

Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor

(2010) B. P. Barnett et al.   SCIENCE

Eating Slowly Increases the Postprandial Response of the Anorexigenic Gut Hormones, Peptide YY and Glucagon-Like Peptide-1

(2009) Alexander Kokkinos et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The role of gut hormones in the regulation of body weight and energy homeostasis

(2009) Efthimia Karra et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Variation of Postprandial PYY3–36Response following Ingestion of Differing Macronutrient Meals in Obese Females

(2008) Nancy Helou et al.   ANNALS OF NUTRITION AND METABOLISM

Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior

(2008) Saima Malik et al.   Cell Metabolism

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

(2008) Zhi-Liang Chu et al.   ENDOCRINOLOGY

Amylin-Mediated Restoration of Leptin Responsiveness in Diet-Induced Obesity: Magnitude and Mechanisms

(2008) James L. Trevaskis et al.   ENDOCRINOLOGY

The effects of pancreatic polypeptide on locomotor activity and food intake in mice

(2008) Y-L Liu et al.   INTERNATIONAL JOURNAL OF OBESITY

Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI)

(2008) James R.C. Parkinson et al.   NEUROIMAGE