Article
Pharmacology & Pharmacy
Shatha Safadi, Harsh Maan, Ilana Kolodkin-Gal, Igor Tsesis, Eyal Rosen
Summary: This study evaluates the effectiveness of probiotic strains in preventing the regrowth of Enterococcus faecalis biofilm cells treated with sodium hypochlorite irrigation. The results show that sodium hypochlorite cannot fully eradicate biofilm cells, while probiotic strains and their products can prevent the regrowth of biofilms.
Article
Microbiology
Jemi Ong, Rose Godfrey, Brad Isaacson, Paul Pasquina, Dustin Williams
Summary: Biofilm contamination is common in patients with percutaneous osseointegrated (OI) implants, leading to frequent infections and discomfort. Oregano essential oil-based gel has shown potential as a therapy for managing biofilms, with significant reduction observed in biofilm burden in samples treated with the gel compared to controls.
Review
Materials Science, Multidisciplinary
Jinhua Li, Hao Shen, Huaijuan Zhou, Rui Shi, Chengtie Wu, Paul K. Chu
Summary: The rise of multidrug-resistant bacteria poses a major threat to global public health, as many pathogenic bacteria can form stubborn biofilms and become resistant to antibiotics. Developing novel antibiotics is urgently needed. In response to these challenges, micro/nanorobots with unique characteristics show promise as an alternative to traditional antimicrobial treatments.
MATERIALS SCIENCE & ENGINEERING R-REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Sumeyye Cesur, Elif Ilhan, Tufan Arslan Tut, Elif Kaya, Basak Dalbayrak, Gulgun Bosgelmez-Tinaz, Elif Damla Arisan, Oguzhan Gunduz, Ewa Kijennska-Gawronnska
Summary: In this study, two-layer poly(vinyl alcohol)/gelatin (PVA/GEL) nanofiber patches containing cinnamaldehyde (CA) in the first layer and gentamicin (GEN) in the second layer were produced. The morphological, chemical, and thermal properties of different types of nanofiber patches were characterized. Mechanical properties, swelling, degradation behavior, and drug release kinetics were investigated. The antibacterial and antibiofilm activities of the patches were evaluated against Pseudomonas aeruginosa and Staphylococcus aureus. The biocompatibility of the materials was also assessed. The study aims to develop an alternative method for treating bacterial keratitis.
Article
Multidisciplinary Sciences
Uthaibhorn Singkham-In, Wichit Thaveekarn, Jureeporn Noiphrom, Orawan Khow, Surada Ponwaranon, Jiraphorn Issara-Amphorn, Visith Sitprija, Asada Leelahavanichkul
Summary: Venoms from king cobra and green pit viper showed broad antibacterial spectrum, but king cobra venom had stronger anti-biofilm activities against P. aeruginosa. A purified amino acid oxidase from king cobra venom reduced biofilm mass and disrupted preformed biofilms, making it a potential agent against Pseudomonas biofilms. Further studies are needed to explore its potential.
SCIENTIFIC REPORTS
(2023)
Review
Engineering, Biomedical
Sang Won Lee, K. Scott Phillips, Huan Gu, Mehdi Kazemzadeh-Narbat, Dacheng Ren
Summary: Microbes have the ability to form biofilms that impact medical device function and infection risk; physicochemical properties of biomaterials play a role in biofilm formation; research on using 3D surface topography for designing antifouling materials against bacterial colonization is gaining interest.
Review
Pharmacology & Pharmacy
Diogo Goncalves, Sandra N. Pinto, Fabio Fernandes
Summary: Extracellular vesicles (EVs) are secreted cell-derived membrane vesicles that play important roles in cell communication. In recent years, it has been found that EVs also play significant roles in infection, as viruses can utilize exosomes (small EVs) to promote viral spreading. Furthermore, exosomes are involved in inflammation and immune responses during bacterial and viral infections. This review summarizes these mechanisms and also discusses the impact of bacterial EVs on immune responses. Additionally, it focuses on the potential and challenges of using EVs to tackle infectious diseases.
Article
Biology
Zhicheng Hu, Pradeep Kumar Kopparapu, Patrick Ebner, Majd Mohammad, Simon Lind, Anders Jarneborn, Claes Dahlgren, Michelle Schultz, Meghshree Deshmukh, Rille Pullerits, Mulugeta Nega, Minh-Thu Nguyen, Ying Fei, Huamei Forsman, Friedrich Goetz, Tao Jin
Summary: PSM alpha and PSM beta play distinct roles in septic arthritis caused by S. aureus, with PSM alpha exacerbating infection and PSM beta protecting against the development of arthritis.
COMMUNICATIONS BIOLOGY
(2022)
Review
Microbiology
Eric P. Skaar
Summary: This article reviews the current and future opportunities for the application of imaging in the study of infectious diseases, highlighting the potential to uncover critical factors and drive innovation in the diagnosis and treatment of infectious diseases.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021
(2021)
Review
Biochemistry & Molecular Biology
Kim Thomsen, Niels Hoiby, Peter Ostrup Jensen, Oana Ciofu, Claus Moser
Summary: Biofilm infections are resistant to host responses and antibiotics. The host immune response plays a crucial role in the outcome and exacerbation of chronic infections. In chronic Pseudomonas aeruginosa lung infections, antibody response and Th1/Th2 imbalance have been associated with a worse outcome.
Article
Pharmacology & Pharmacy
Magda Ferreira, Sandra N. Pinto, Frederico Aires-da-Silva, Ana Bettencourt, Sandra I. Aguiar, Maria Manuela Gaspar
Summary: The study evaluated the therapeutic benefits of combining three antibiotics (vancomycin, levofloxacin, and rifabutin) with nanotechnological platforms, with RFB showing the strongest antibacterial effect when incorporated into liposomes. Negatively charged RFB liposomes showed promising potential against biofilm-associated Staphylococcus aureus infections and displayed better performance in in vitro studies. Further in vivo studies are recommended to validate the findings.
Article
Microbiology
Jemi Ong, Rose Godfrey, Alexa Nazarian, Joshua Tam, Brad M. Isaacson, Paul F. Pasquina, Dustin L. Williams
Summary: This study investigates the efficacy of antimicrobial blue light (aBL) therapy against planktonic and biofilm bacteria. The results show that aBL has a significant efficacy disparity between the two phenotypes and its efficacy increases with exposure time.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Mario Jacques, Francois Malouin
Summary: Bacterial biofilm and non-attached aggregates formation are crucial for bacterial survival and may play important roles in host and environmental persistence, as well as transmission between different species and individuals.
VETERINARY RESEARCH
(2022)
Review
Biotechnology & Applied Microbiology
R. Pereira, R. O. dos Santos Fontenelle, E. H. S. de Brito, S. M. de Morais
Summary: Candida albicans is a versatile fungal pathogen that can transition from commensal to pathogenic through the production of virulence factors, particularly through the formation of biofilms. Biofilms formed by C. albicans are not easily treated with current therapeutic agents, highlighting the importance of ongoing research to develop new antifungals.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yuan-Pin Hung, Yu-Fon Chen, Pei-Jane Tsai, I-Hsiu Huang, Wen-Chien Ko, Jeng-Shiung Jan
Summary: Bacteria-targeting nanomaterials have been widely used for diagnosis and treatment of bacterial infectious diseases, showing great potential as antimicrobial agents. These materials prevent bacterial colonization and spreading, benefiting biomaterial implants. Tailoring nanomaterials for wound repair and incorporating immune activating adjuvants can improve function and prevent bacterial infections.
Editorial Material
Pediatrics
Nora M. Haney, John P. Gearhart
Summary: This commentary reviews the research on long-term potential problems in patients with cloacal exstrophy.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Nora M. Haney, Chad B. Crigger, Tamir Sholklapper, Shwetha Mudalegundi, Angelica Griggs-Demmin, Isam W. Nasr, Paul Sponseller, John P. Gearhart
Summary: This study assessed the impact of different osteotomy and pelvic fixation methods on the outcomes of primary closure surgery for cloacal exstrophy. It was found that multi-stage procedures were more common and had higher success rates than single-stage procedures, and any osteotomy was associated with successful closure. The fixation methods also changed, with an increase in Buck's traction and external fixation and a decrease in spica casting. A multidisciplinary approach with a combination osteotomy was found to improve surgical outcomes.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Editorial Material
Urology & Nephrology
Angelica Claire Griggs-Demmin, Shwetha Mudalegundi, Nora Haney, Andrew Cohen
Review
Microbiology
Justine S. Nicholson, Kyle S. Landry
Summary: Bacterial biofilms, which adhere to various surfaces, have been found to impact oral and intestinal health as well as neurodegenerative diseases. This review article provides insight into the role of bacterial biofilms in the development and progression of neurodegenerative diseases, shedding light on an important area of research.
Article
Urology & Nephrology
Bruce J. Trock, Yuezhou Jing, Brent Mabey, Zaina Sangale, Lauren Lenz, Nora Haney, Igor Vidal, Stephanie A. Glavaris, Gunes Guner, Onur Ertunc, Ibrahim Kulac, Javier A. Baena Del Valle, Tracy Jones, Misop Han, Alan W. Partin, Todd Cohen, Steven Stone, Angelo M. De Marzo
Summary: The study showed that cell-cycle progression was independently associated with metastasis-free survival in prostate cancer patients, particularly those receiving salvage radiotherapy, while phosphatase and tensin homolog had weaker correlation with metastasis after adjustment for post-surgical risk assessment.
JOURNAL OF UROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia Stabinska, Aruna Singh, Nora M. Haney, Yuguo Li, Farzad Sedaghat, Max Kates, Michael T. McMahon
Summary: This study investigates the potential of DCE MR CEST urography for assessing renal function in mice with unilateral ureter obstruction (UUO) by simultaneous pH and renal uptake/clearance measurements. The results show that DCE-MR-CEST urography can detect changes in renal uptake/excretion and pH homeostasis and distinguish between obstructed and unobstructed kidney as early as 1 day after UUO.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Urology & Nephrology
Tamir Sholklapper, Chad Crigger, Christian Morrill, Thomas G. W. Harris, Nora Haney, Kathy Lue, Ezekiel Young, John P. Gearhart
Summary: This study reviewed the long-term outcomes and experience of using the tunica vaginalis flap (TVF) for complex epispadias repair. The study found that in patients who underwent TVF, 7 developed urethrocutaneous fistulae, 1 had dehiscence, and 1 had both. The results suggest that the use of the tunica vaginalis as an adjunct to epispadias repair can effectively prevent the development of urethrocutaneous fistulae.
Article
Pediatrics
Tamir N. Sholklapper, Chad Crigger, Nora Haney, Preeya Khandge, Wayland Wu, Paul D. Sponseller, John P. Gearhart
Summary: Despite similar rates of closure success and overall complications, patients with CE are more prone to superficial pin-site infections after pelvic osteotomy. External hip fixation may contribute to increased orthopedic complications, but further research is needed to understand the underlying causes of these complications.
JOURNAL OF PEDIATRIC UROLOGY
(2022)
Article
Pediatrics
Hannah Guan, Tamir Sholklapper, Chad Crigger, Nora Haney, Thomas G. W. Harris, John P. Gearhart
Summary: This study describes a bladder neck reconstruction (BNR) with a modified Tanagho anterior detrusor flap for the treatment of posterior urethral stricture after repair of classic bladder exstrophy. Five patients underwent proximal urethral reconstruction with modified Tanagho flap, and four male patients with classic bladder exstrophy were successfully treated for posterior urethral strictures. The technique showed excellent long-term success rates with no recurrence of stricture.
JOURNAL OF PEDIATRIC UROLOGY
(2023)
Article
Urology & Nephrology
Shwetha Mudalegundi, Angelica Griggs-Demmin, Nora M. Haney, Nirmish Singla
Summary: A 23-year-old man was incidentally diagnosed with an adrenal ganglioneuroma (AG) during workup for acute abdominal pain. After undergoing a right open adrenalectomy, the patient had an uneventful recovery.
UROLOGY CASE REPORTS
(2022)
Editorial Material
Obstetrics & Gynecology
Liam F. Nugent, Nora M. Haney, Taylor P. Kohn
FERTILITY AND STERILITY
(2023)
Article
Pediatrics
Nora M. Haney, Oscar Li, Pranjal Agrawal, Taylor P. Kohn, Chad Crigger, Tamir Sholklapper, Heather DiCarlo, John P. Gearhart
Summary: Adult patients with exstrophy-epispadias complex (EEC) have higher rates of opioid and benzodiazepine prescriptions. The severity of anomalies, female sex, and increasing age are associated with a higher likelihood of receiving prescriptions.
JOURNAL OF PEDIATRIC UROLOGY
(2023)
Article
Pediatrics
Ahmad Haffar, Alexander M. Hirsch, Chad B. Crigger, Thomas G. W. Harris, Nora M. Haney, Logan B. Galansky, Isam W. Nasr, Paul D. Sponseller, John P. Gearhart
Summary: This study compares the orthopedic complications between staged and non-staged pelvic osteotomies in the closure of extreme pubic diastasis of cloacal exstrophy. The results show that staged pelvic osteotomy is a safe alternative to non-staged osteotomy and can decrease the risk of closure failure in this group.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Taylor Kohn, Nora Haney, Amin S. Herati, Max Kates, Kenneth Pienta
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Urology & Nephrology
Nora Haney, Shwetha Mudalegundi, Angelica Griggs-Demmin, Tamir Sholklapper, Edwin Smith, Charlotte Wu
JOURNAL OF UROLOGY
(2022)