Article
Cell Biology
Lorena Perdices, Lorena Fuentes-Broto, Francisco Segura, Ana Cavero, Elvira Orduna-Hospital, Gema Insa-Sanchez, Ana Isabel Sanchez-Cano, Laura Fernandez-Sanchez, Nicolas Cuenca, Isabel Pinilla
Summary: EGCG can protect against retinal degenerative diseases and reduce visual function loss in animal models of RP.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Joseph Thomas Ortega, Tanu Parmar, Miguel Carmena-Bargueno, Horacio Perez-Sanchez, Beata Jastrzebska
Summary: This study demonstrates the pharmacological potential of quercetin in slowing down the progression of retinitis pigmentosa and mitigating the detrimental effects of the P23H Rho mutation. Quercetin improves stability and function of P23H Rho, as well as retinal morphology and function in mice. It also downregulates UPR signaling and oxidative stress markers.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Liangwei Mei, Yi Zheng, Teng Ma, Bing Xia, Xue Gao, Yiming Hao, Zhuojing Luo, Jinghui Huang
Summary: The circadian clock is crucial for managing daily physiological and metabolic processes, and disturbances can lead to degenerative diseases. EGCG, a compound with antioxidant properties, has been found to have protective effects on intervertebral disc degeneration by entraining the biological clock. This study provides evidence that EGCG's protective effects on NPCs are related to the circadian clock and depend on the core clock gene Bmal1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Jingxin Chen, Wanyao Ma, Jiangchuan Yu, Xi Wang, Hongling Qian, Ping Li, Haiqiong Ye, Yue Han, Zhengding Su, Meng Gao, Yongqi Huang
Summary: This study found that the green tea polyphenol EGCG promotes the formation of liquid tau droplets by interacting with the proline-rich domain of tau through hydrophobic interactions and hydrogen bonds. The oxidation of EGCG, tau phosphorylation, and the chemical structure of polyphenols all influence the effectiveness of EGCG in facilitating tau liquid-liquid phase separation (LLPS). These findings provide new insights into the biological activity of EGCG and suggest potential mechanisms for its role in alleviating neurodegenerative diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Priscila Baltazar Goncalves, Ana Carolina Renno Sodero, Yraima Cordeiro
Summary: The major bioactive compound EGCG in green tea shows potential for treating neurodegenerative diseases by targeting protein misfolding and aggregation. There is an urgent need to develop effective drugs for these incurable ailments, and EGCG may offer opportunities in drug discovery for NDs.
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Pharmacology & Pharmacy
Merve Sen, Marco Bassetto, Florent Poulhes, Olivier Zelphati, Marius Ueffing, Blanca Arango-Gonzalez
Summary: The use of magnetic nanoparticles and magnetic force for delivering siRNA into retinal tissue proved to be a safe and effective method, showing potential therapeutic effects by silencing the VCP gene and reducing retinal degeneration in an animal model for retinitis pigmentosa.
Article
Biochemistry & Molecular Biology
Shih-Fang Wu, Chih-Yao Lin, Rong-Kung Tsai, Yao-Tseng Wen, Feng-Huei Lin, Chia-Yu Chang, Ching- Shen, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Chin-San Liu, Yan-Ting Chen, Hong-Lin Su
Summary: Research found that mitochondrial transplantation can moderately attenuate the degeneration of retinal layers in RCS rats. This result was confirmed through histological examination and OCT measurement of retina thickness. VEP analysis showed that the transmission time of electrical signals after mitochondrial transplantation was similar to the normal value. The results suggest that mitochondrial transplantation can improve the degeneration of photoreceptors in RCS rats and have potential for clinical application.
Article
Food Science & Technology
Nadine Tritsch, Marc C. Steger, Valerie Segatz, Patrik Blumenthal, Marina Rigling, Steffen Schwarz, Yanyan Zhang, Heike Franke, Dirk W. Lachenmeier
Summary: This article reviews the safety of coffee leaf tea, highlighting caffeine and epigallocatechin gallate (EGCG) as potentially hazardous substances. The caffeine content is comparable to roasted coffee beans, while the EGCG content is typically low. The article suggests a maximum intake of 1-3 cups per day of coffee leaf tea. The conclusion is that coffee leaf tea is not assumed to be risky for consumers.
Article
Biology
Ryoji Amamoto, Grace K. Wallick, Constance L. Cepko
Summary: Retinitis Pigmentosa (RP) is a progressive visual disorder caused by mutations in genes. Research has found that retinoic acid (RA) signaling is crucial for the survival of peripheral cones in the retina, providing a potential strategy for preserving cone-mediated vision.
Article
Chemistry, Medicinal
Francesca Picarazzi, Marika Zuanon, Gaia Pasqualetto, Silvia Cammarone, Isabella Romeo, Mark T. Young, Andrea Brancale, Marcella Bassetto, Mattia Mori
Summary: A computational-boosted workflow was used to select potential chaperones for P23H opsins using homology modeling, molecular dynamics simulations, and virtual screening. In vitro studies confirmed the reliability of the generated structural model and identified new chemotypes of safe and effective chaperones that can enhance P23H opsin trafficking to the outer cell membrane.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Biochemistry & Molecular Biology
Yogita Kanan, Sean F. Hackett, Henry T. Hsueh, Mahmood Khan, Laura M. Ensign, Peter A. Campochiaro
Summary: Retinitis pigmentosa (RP) is a genetic disorder that causes rod photoreceptor degeneration and subsequent cone photoreceptor degeneration. Reduced oxygen consumption from the loss of rods leads to retinal hyperoxia and oxidative stress, resulting in cone cell death and degeneration. However, reducing inspired oxygen levels can reduce retinal hyperoxia, preserve cone structure and function, and decrease oxidative damage in animal models of RP.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Natalia Martinez-Gil, Oksana Kutsyr, Agustina Noailles, Laura Fernandez-Sanchez, Lorena Vidal, Xavier Sanchez-Saez, Carla Sanchez-Castillo, Pedro Lax, Nicolas Cuenca, Antonio G. Garcia, Victoria Maneu
Summary: P2X7R and P2X4R play important roles in retinal diseases and their expression increases during disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jose-Alain Sahel, Elise Boulanger-Scemama, Chloe Pagot, Angelo Arleo, Francesco Galluppi, Joseph N. Martel, Simona Degli Esposti, Alexandre Delaux, Jean-Baptiste de Saint Aubert, Caroline de Montleau, Emmanuel Gutman, Isabelle Audo, Jens Duebel, Serge Picaud, Deniz Dalkara, Laure Blouin, Magali Taiel, Botond Roska
Summary: Optogenetics combined with engineered goggles enabled partial recovery of visual function in a blind patient, as demonstrated by object-related brain activity recorded through electroencephalography. This represents the first reported case of partial functional recovery in a neurodegenerative disease after optogenetic therapy.
Review
Neurosciences
Luiza Fernandes, Thyago R. Cardim-Pires, Debora Foguel, Fernando L. Palhano
Summary: The accumulation of protein aggregates in human tissues is a hallmark of more than 40 diseases called amyloidoses, with seven of them being associated with neurodegenerative processes. EGCG, a natural compound found in green tea, has shown potential in inhibiting protein aggregation, reducing toxicity, and remodeling fibril structures in neurodegenerative diseases such as AD, PD, and HD.
FRONTIERS IN NEUROSCIENCE
(2021)
Meeting Abstract
Ophthalmology
Oksana Kutsyr, Agustina Noailles, Natalia Martinez-Gil, Lucia Maestre-Carballa, Manuel Martinez-Garcia, Laura Fernandez-Sanchez, Victoria Maneu, Nicolas Cuenca, Pedro Lax
ACTA OPHTHALMOLOGICA
(2022)
Meeting Abstract
Ophthalmology
Henar Albertos-Arranz, Xavier Sanchez-Saez, Natalia Martinez-Gil, Agustina Noailles Gil, Ramon Calvo Andres, Clara Monferrer Adsuara, Lidia Remoli Sargues, Javier Montero Hernandez, Nicolas Cuenca
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Diana Soriano Pina, Elvira Orduna-Hospital, Carmen Lopez-de-la-Fuente
Summary: This study aimed to investigate the VF test using different prismatic power combinations and determine the best prismatic power. The results showed that VF increased with age, and 3BI/12BO (increment) provided the best results in both near and far vision.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Letter
Ophthalmology
Ana Boned-Murillo, Maria D. Diaz-Barreda, Isabel Pinilla
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Review
Clinical Neurology
Jee-Young Lee, Antonio Martin-Bastida, Ane Murueta-Goyena, Inigo Gabilondo, Nicolas Cuenca, Paola Piccini, Beomseok Jeon
Summary: This review highlights the importance of in vivo imaging biomarkers for early diagnosis and monitoring of Parkinson disease (PD). By combining various imaging techniques such as PET, single-photon emission CT, MRI, and retinal optical coherence tomography (OCT), the early diagnosis and management of PD can be aided.
NATURE REVIEWS NEUROLOGY
(2022)
Editorial Material
Cell Biology
Victoria Maneu, Pedro Lax, Nicolas Cuenca
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell Biology
Lorena Perdices, Lorena Fuentes-Broto, Francisco Segura, Ana Cavero, Elvira Orduna-Hospital, Gema Insa-Sanchez, Ana Isabel Sanchez-Cano, Laura Fernandez-Sanchez, Nicolas Cuenca, Isabel Pinilla
Summary: EGCG can protect against retinal degenerative diseases and reduce visual function loss in animal models of RP.
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, General & Internal
Guisela Fernandez-Espinosa, Ana Boned-Murillo, Elvira Orduna-Hospital, Maria Dolores Diaz-Barreda, Ana Sanchez-Cano, Sofia Bielsa-Alonso, Javier Acha, Isabel Pinilla
Summary: This study evaluated retinal vascularization in patients with type 2 diabetes mellitus and moderate diabetic retinopathy using optical tomography angiography. The results showed a decrease in vascular density and an increase in foveal avascular zone area, with significant correlations to disease duration and age.
Review
Biochemistry & Molecular Biology
Ana Boned-Murillo, Henar Albertos-Arranz, Maria Dolores Diaz-Barreda, Elvira Orduna-Hospital, Ana Sanchez-Cano, Antonio Ferreras, Nicolas Cuenca, Isabel Pinilla
Summary: Optical coherence tomography angiography (OCTA) is an essential tool for the diagnosis and control of diabetic patients, allowing visualization and analysis of the retinal and choroidal microvasculature, and the detection of diabetic retinopathy and other related diseases.
Review
Biochemistry & Molecular Biology
Isabel Pinilla, Victoria Maneu, Laura Campello, Laura Fernandez-Sanchez, Natalia Martinez-Gil, Oksana Kutsyr, Xavier Sanchez-Saez, Carla Sanchez-Castillo, Pedro Lax, Nicolas Cuenca
Summary: Inherited retinal dystrophies (IRDs) are a group of genetically and clinically heterogeneous diseases characterized by progressive degeneration of the retina and loss of visual function. Oxidative stress and inflammation play key roles in the pathophysiology of IRDs. Gene therapy has shown some success in treating IRDs, but other therapeutic strategies targeting oxidative stress and inflammation are also being investigated.
Editorial Material
Biochemistry & Molecular Biology
Isabel Pinilla, Victoria Maneu
Article
Ophthalmology
Henar Albertos-Arranz, Natalia Martinez-Gil, Xavier Sanchez-Saez, Agustina Noailles, Clara Monferrer Adsuara, Lidia Remoli Sargues, Juan J. Perez-Santonja, Pedro Lax, Ramon Calvo Andres, Nicolas Cuenca
Summary: This study aimed to determine whether COVID-19 affected retinal cells and establish correlations with clinical parameters. Immunostaining and confocal microscopy analysis revealed that Muller cells in COVID-19 patients showed stronger expression of ACE2 and CRALBP, and the retinas exhibited glial activation and neuronal alterations, mainly related to inflammation, hypoxic conditions, and age.
Article
Health Care Sciences & Services
Guisela Fernandez-Espinosa, Carlos Ruiz-Tabuenca, Elvira Orduna-Hospital, Isabel Pinilla, Francisco J. Salgado-Remacha
Summary: The aim of this study was to reduce the variability of manual segmentation of the Foveal Avascular Zone (FAZ) in retinal optical coherence tomography angiography (OCTA) images. A new criterion was established based on the comparison of segmentations by different observers, resulting in smaller FAZ areas and slightly reduced acircularity values in all groups.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ana Boned-Murillo, Guisela Fernandez-Espinosa, Elvira Orduna-Hospital, Maria Dolores Diaz-Barreda, Ana Sanchez-Cano, Maria Sopena-Pinilla, Sofia Bielsa-Alonso, Isabel Pinilla
Summary: This study analyzes the retinal thickness and sensitivity in DM2 patients and correlates the results with blood lipid levels and MAIA measurements, providing an accurate method for assessing moderate DR in DM2 patients. Thinning of GCL+ and GCL++ may support ganglion cell loss before RNFL damage.