Article
Chemistry, Multidisciplinary
Kim Shortall, Simin Arshi, Simon Bendl, Xinxin Xiao, Serguei Belochapkine, Denise Demurtas, Tewfik Soulimane, Edmond Magner
Summary: The use of enzymes in biochemical processes is advantageous due to their ability to work under mild conditions while achieving high reaction rates. Cofactor regeneration using bienzymatic recycling systems is an attractive method to increase productivity and efficiency. In this study, immobilized ALDH(Tt) and LDH@agarose showed good performance in terms of conversion, reuse, and storage, demonstrating the potential of these systems for practical applications. A coupled reactor containing immobilized ALDH(Tt)-LDH exhibited efficient cofactor regeneration and enhanced product yields.
Article
Chemistry, Applied
Joao P. B. Oliveira, Yandra A. P. Nascimento, Kimberle P. S. Amorim, Luciana R. B. Goncalves, Larissa B. N. Freitas, Ayrles F. B. Silva, Odair P. Ferreira, Marcio V. Ramos, Pedro F. N. Souza, Jefferson S. Oliveira, Nilton A. S. Neto, Luciana G. Mendonca, Rafael A. Zambelli, Cleverson D. T. Freitas
Summary: The immobilization of Calotropis procera cysteine peptidases (CpCPs) on glyoxyl-agarose (glyoxyl-CpCPs) was found to maintain the proteolytic activity of the enzymes, exhibiting similar performance in casein hydrolysis and cheese production compared to soluble CpCPs and chymosin.
Article
Agricultural Engineering
Nicolas Ramirez, Claudia Ubilla, Javiera Campos, Francisca Valencia, Carla Aburto, Carlos Vera, Andres Illanes, Cecilia Guerrero
Summary: The study evaluated the effects of operational variables on lactulose production by enzymatic transgalactosylation in fed-batch and repeated fed-batch. Feed flowrate and fructose to lactose molar ratio were the most significant variables affecting lactulose yield, productivity, and selectivity. The repeated fed-batch operation increased efficiency of biocatalyst use and accumulated productivity significantly compared to batch and fed-batch operations with the same biocatalyst.
BIORESOURCE TECHNOLOGY
(2021)
Article
Chemistry, Applied
Daniel Francis, A. John Blacker, Nikil Kapur, Stephen P. Marsden
Summary: The new modular photochemical continuous stirred-tank reactor (CSTR) design utilizes light-source units developed for the fReactor CSTR platform, making it suitable for both homogeneous and multiphasic reactions. By using slurries as input feeds, the system intensifies photochemical brominations, and its modular nature facilitates the integration of downstream reaction steps.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Biochemistry & Molecular Biology
Marcela Serey, Carlos Vera, Cecilia Guerrero, Andres Illanes
Summary: Aspergillus oryzae beta-galactosidase was immobilized in in-house quaternary ammonium agarose (QAA) for the first time to synthesis lactulose, resulting in a biocatalyst with high specific activity. The immobilized enzyme showed higher yield and specific productivity in batch reactions, and the support could be reused without compromising yield, productivity, and selectivity, reducing economic impact.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Computer Science, Artificial Intelligence
Gongming Wang, Qing-Shan Jia, Junfei Qiao, Jing Bi, MengChu Zhou
Summary: This work introduces a deep learning-based model predictive control (DeepMPC) for modeling and controlling a continuous stirred-tank reactor (CSTR) system. DeepMPC achieves high performance in system identification and control through automatic determination of size and quadratic optimization.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2021)
Article
Green & Sustainable Science & Technology
Hao Jiang, Wenchuan Hao, Yeqing Li, Hongjun Zhou
Summary: Biological methanation process is beneficial for upgrading anaerobic digestion, efficient utilization of surplus electricity and H-2, energy storage and peak regulation, as well as CO2 emission reduction. Continuous stirred tank reactor (CSTR) is an economical and convenient method for methanation. The study found that the reactor could run stably at a pH around 8.5, and CO2 flow was adjusted for pH control. Different stages of the process showed significant succession in the microbial community.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Engineering, Environmental
S. S. Hoseini, G. Najafi, B. Ghobadian, A. H. Akbarzadeh
Summary: This study investigates the importance of mixing in the chemical industry and proposes a computational framework for optimizing power consumption and impeller stress in stirred-tank reactors. By using Computational Fluid Dynamic (CFD) analysis, the study examines three types of impellers and utilizes Multi-objective Genetic Algorithm (MOGA) to optimize the geometrical parameters of the blades. The results show a decrease in power consumption with V- and U-shape impellers compared to the 6-blade Rushton turbine, and indicate differences in turbulent kinetic energy and stress distribution among different impeller designs.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Mathematics, Applied
Shi Liu, Song Chen, Tehuan Chen, Zhigang Ren
Summary: This paper proposes a residual neural network-based observer for CSTR systems, which can quickly and accurately observe the state changes during the CSTR reaction.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2024)
Article
Chemistry, Physical
Kathirvel Brindhadevi, Rajasree Shanmuganathan, Arivalagan Pugazhendhi, P. Gunasekar, S. Manigandan
Summary: This study demonstrates a numerical approach to predicting biohydrogen and biogas production in horizontal and vertical continuous mixed tank reactors. It found that impeller speed has a significant impact on production rates, while the optimal ranges of HRT and pH are crucial factors.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Environmental Sciences
L. Rocha, E. M. L. Sousa, M. V. Gil, M. Otero, V. I. Esteves, V. Calisto
Summary: This study evaluated the dynamic removal of diclofenac (DCF) from water and wastewater using waste-based magnetic activated carbon (MAC) in a continuous-flow stirred tank reactor (CSTR) for the first time. The results demonstrated the feasibility of producing MAC composites with high adsorption efficiency, easy retrievability, and successful regeneration for further reutilization.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Environmental Sciences
Francesco Bianco, Marco Race, Stefano Papirio, Giovanni Esposito
Summary: The widespread presence of polycyclic aromatic hydrocarbons (PAHs) in marine sediments has ecological and human health implications. Sediment washing (SW) has been found to be an effective remediation approach for PAH-polluted sediments, but concerns about waste handling remain. This study investigated the biological treatment of a synthetic PAH-polluted SW solution using a continuous-flow stirred-tank reactor. The results showed that a PHE removal efficiency of up to 75-94% was achieved, mainly through biodegradation by a PHE-degrading consortium composed of Proteobacteria, Bacteroidota, and Firmicutes phyla.
ENVIRONMENTAL RESEARCH
(2023)
Article
Energy & Fuels
Endong Miao, Xufan Zheng, Zhuo Xiong, Yongchun Zhao, Junying Zhang
Summary: This study systematically investigated the direct aqueous mineral carbonation of carbide slag under various conditions. A novel kinetic model based on the Two-Film Theory was proposed and showed excellent agreement with experimental data. Carbonation efficiencies of over 90% were achieved in all experiments. The rate-controlling step of the reaction changed from gas-liquid mass transfer initially to solid-liquid mass transfer at later stages. Changes in the mineralogy and morphology of the carbide slag confirmed the reaction mechanism, and the effect of operating parameters on gas-liquid mass transfer was quantitatively investigated. This study contributes to the large-scale, rational utilization of energy and optimization of CO2 mineral carbonation in gas-liquid-solid reaction systems.
Article
Engineering, Chemical
J. N. Delbridge, T. A. Barrett, A. Ducci, M. Micheletti
Summary: This study investigated the microcarrier suspension performance and flow fields in a scale-down mimic of Allegro STR single-use bioreactor range compared to a standard cylindrical configuration. It was found that the down-pumping mode in the A-STR achieved homogeneous suspension at a considerably lower power input compared to other configurations. Flow structures at the just-suspended condition were similar to those in the turbulent regime. Baffles significantly reduced the power input required for suspension, except for the A-STR (DP) configuration.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Article
Energy & Fuels
Namrata Gaikwad, Jitendra S. Sangwai, Rajnish Kumar, Praveen Linga
Summary: The study found that the addition of L-tryptophan significantly enhances the kinetics of CO2-CH4 hydrate formation, increasing the rate of hydrate formation and gas uptake.
