期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2020.00655
关键词
gold nanoparticle; reduced graphene oxide; photoacoustic imaging; the second near-infrared window; photothermal therapy; ovarian cancer
资金
- Shanghai Municipal Key Clinical Specialty [shslczdzk06302]
- National Natural Science Foundation of China [81172477, 81402135]
- Project of the Science and Technology Commission of Shanghai Municipality [17441907400]
- Shanghai Jiao Tong University Medicine-Engineering Fund [YG2017MS41]
- Post-doctoral Science Foundation of China [2018M632128]
We explore a sandwich-type gold nanoparticle coated reduced graphene oxide (rGO-AuNP) as an effective nanotheranostic platform for the second near-infrared (NIR-II) window photoacoustic (PA) imaging-guided photothermal therapy (PTT) in ovarian cancer. The PEG was loaded onto the AuNPs surface to increase the stability of nanostructure. The forming rGO-AuNPs- PEG revealed very strong SERS signal, NIR-II PA signal and high photothermal efficiency against tumor upon 1,061 nm laser irradiation. The prominent performance was attributed to the plasmonic coupling of AuNPs, and the enhanced response of rGO and the plasmonic AuNP. Thus, our study demonstrates that the rGO-AuNP nanocomposite could promise to be a potential photothermal agent and pave the way for the diagnosis and therapy of ovarian cancer in the future.
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