Article
Biochemistry & Molecular Biology
Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun
Summary: KIAA1217 plays a crucial role in hepatocellular carcinoma (HCC) metastasis by promoting cell migration and invasion through inducing epithelial-mesenchymal transition (EMT), and activating JAK1/2 and STAT3. It interacts with the Notch and Wnt/β-catenin pathways to facilitate HCC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jiajia Gao, Lusong Tian, Yulin Sun, Wei Li, Lina Zhao, Yan Sun, Zongpan Jing, Lanping Zhou, Fang Liu, Xiaohang Zhao
Summary: PUR alpha promotes cell growth, migration, and invasion in ESCC, likely through inducing EMT to contribute to the progression of ESCC. High expression of PUR alpha is associated with lymph node metastasis, advanced AJCC stage, and worse survival outcomes in ESCC patients.
Article
Biotechnology & Applied Microbiology
Huiming Zhang, Shuang Liu, Liqiang Chen, Yanliang Sheng, Wenzhe Luo, Gang Zhao
Summary: miR-509-3p inhibits the proliferation, migration, invasion, and EMT of HCC cells by negatively regulating Twist, thereby suppressing HCC development and metastasis.
Article
Oncology
Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du, Baocai Xing
Summary: This study found that PPP1R26 is upregulated in hepatocellular carcinoma (HCC) and is significantly associated with metastasis and poor patient survival. PPP1R26 promotes glycolysis by enhancing the splicing of PKM2 and activates epithelial-mesenchymal transition (EMT) by forming a PPP1R26-PKM2-TGIF2 complex, driving the progression of HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Anastasios Goulioumis, Kostis Gyftopoulos
Summary: Epithelial-to-mesenchymal transition (EMT) is a molecular phenomenon that occurs in epithelial neoplasms, such as laryngeal carcinoma. EMT leads to the loss of epithelial traits and acquisition of mesenchymal traits by tumor cells, enhancing their migratory capacity. EMT is mediated by complex molecular pathways and involves various changes, including loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, etc. Partial EMT models have been accepted to explain the cell plasticity associated with invasion and metastasis of tumors.
Article
Cell Biology
Yu-Chuan Yan, Guang-Xiao Meng, Chun-Cheng Yang, Ya-Fei Yang, Si-Yu Tan, Lun-Jie Yan, Zi-Niu Ding, Yun-Long Ma, Zhao-Ru Dong, Tao Li
Summary: In this study, the DAGLA/2-AG axis is found to promote HCC progression by regulating cell proliferation, invasion, and metastasis. Furthermore, DAGLA induces resistance to lenvatinib therapy during HCC treatment. Therefore, inhibiting the DAGLA/2-AG axis could be a novel therapeutic strategy to inhibit HCC progression and enhance the therapeutic effects of TKIs.
CELL DEATH & DISEASE
(2023)
Review
Gastroenterology & Hepatology
Gan Du, Ruizhe Yang, Jianguo Qiu, Jie Xia
Summary: Hepatocellular carcinoma (HCC) is a common and deadly cancer, and its pathogenesis is not well understood. Genomic instability is a key factor in the development of HCC, and histone deacetylases (HDACs) play a crucial role in DNA repair and genome stability.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Review
Integrative & Complementary Medicine
Jia-jia Li, Qing Liang, Guang-chun Sun
Summary: Hepatocellular carcinoma is a prevalent malignant cancer globally, and the epithelial-mesenchymal transition plays a crucial role in early metastasis. Traditional Chinese medicines have been recognized for their inhibitory effects on HCC, but research on their impact on EMT in HCC is limited and requires further investigation.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Oncology
Hongchi Yu, Jia He, Guanyue Su, Yuelong Wang, Fei Fang, Wenxing Yang, Kaiyun Gu, Naiyang Fu, Yunbing Wang, Yang Shen, Xiaoheng Liu
Summary: The study revealed that fluid shear stress facilitated cytoskeleton rearrangement in hepatocellular carcinoma cells, leading to the release of YAP from integrin beta subunit and subsequent activation of EMT-regulating transcription factor SNAI1 and expression of EMT-related genes. FSS-treated HepG2 cells exhibited significantly increased tumorigenesis and metastasis in vivo.
MOLECULAR ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Ying Liu, Dao-Hai Cheng, Ke-Dao Lai, Hua Su, Guo-Shou Lu, Li Wang, Ji-Hua Lv
Summary: Ventilagolin suppresses the migration, invasion, and EMT of HCC cells by downregulating Pim-1, showing potential therapeutic effects. In vivo experiments demonstrate that Ventilagolin effectively inhibits HCC tumor growth and regulates the expression of Pim-1 and EMT-related proteins.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Integrative & Complementary Medicine
Mo Jie, Zhao-Qi Zhang, Ning Deng, Qiu-Meng Liu, Chao Wang, Qian-Yun Ge, Peng-Chen Du, Sha-Sha Song, Xue-Wu Zhang, Long-Xin, Hui-Fang Liang, Liang Chu, Lei Mang, Xiao-Ping Chen, Jin Chen, Han-Hua Dong, Bi-Xiang Zhang
Summary: 18 beta-glycyrrhetinic acid (GA) inhibits TGF-beta-induced epithelial-mesenchymal transition (EMT) and metastasis of hepatocellular carcinoma (HCC) cells by reducing the phosphorylation of signal transducer and activator of transcription 3 (STAT3). This provides a potential therapeutic target for HCC management.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Spectroscopy
Yi Shu, Chaoqun Huang, Hongjing Liu, Feiyang Hu, Hongmei Wen, Jian Liu, Xinzhi Wang, Chenxiao Shan, Wei Li
Summary: In this study, a near-infrared (NIR) fluorescent probe named Lys-HXPI was designed and synthesized to effectively detect Carboxylesterases (CESs) and Histone deacetylases (HDACs), which are important signaling enzymes highly associated with the development and progression of multiple cancers, including hepatocellular carcinoma (HCC). The probe displayed strong NIR emission, low detection limits, high selectivity, and the ability to simultaneously image CESs and HDACs in living cells, tumor-bearing mice, and tissue slices.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Oncology
Rongzhong Xu, Liubing Lin, Bo Zhang, Jian Wang, Fanchen Zhao, Xiaolin Liu, Yiping Li, Yan Li
Summary: The study found that BIRC5 was highly expressed in HCC samples and associated with poor prognosis. Through WGCNA, 180 module genes were screened, overlapped with 241 DEGs, ultimately obtaining 33 candidate genes. Cox regression analyses identified 8 genes which were used to construct a risk signature, showing high accuracy in predicting clinical outcomes and closely related to clinicopathological characteristics of HCC patients. IPA suggested these 8 genes were enriched in cancer and immune-related pathways.
Review
Medicine, Research & Experimental
Jiahao Xue, Penglei Ge, Yang Wu
Summary: This study conducted a meta-analysis to investigate the significance of different types of HDACs in HCC prognosis and clinicopathological features. The high expression of class I, II, and III HDACs was associated with poorer overall survival and various clinicopathological characteristics. These findings suggest that different types of HDACs may serve as valuable biomarkers for HCC.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang, Chenghong Wang
Summary: miR-124-3p inhibits HCC proliferation and epithelial-mesenchymal transition (EMT) by targeting ARRDC1.
