Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes

Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector

(2019) Steven Mayers et al.   BMC BIOTECHNOLOGY

Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironment

(2019) Miranda Machacek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current best practices in single‐cell RNA‐seq analysis: a tutorial

(2019) Malte D Luecken et al.   Molecular Systems Biology

Retinal and optic nerve degeneration in liver X receptor β knockout mice

(2019) Xiao-yu Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency

(2019) Yaqian Duan et al.   CIRCULATION RESEARCH

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

(2018) Joakim S. Dahlin et al.   BLOOD

Mapping the Mouse Cell Atlas by Microwell-Seq

(2018) Xiaoping Han et al.   CELL

Liver X receptors in lipid signalling and membrane homeostasis

(2018) Bo Wang et al.   Nature Reviews Endocrinology

The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease

(2018) Michael B. Fessler   PHARMACOLOGY & THERAPEUTICS

Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction

(2018) Yaqian Duan et al.   STEM CELLS

Influence of cholesterol/caveolin-1/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells

(2018) Jihee Sohn et al.   Stem Cell Research & Therapy

Loss of the Liver X Receptors Disrupts the Balance of Hematopoietic Populations, With Detrimental Effects on Endothelial Progenitor Cells

(2018) Adil Rasheed et al.   Journal of the American Heart Association

Population snapshots predict early haematopoietic and erythroid hierarchies

(2018) Betsabeh Khoramian Tusi et al.   NATURE

Circulating angiogenic stem cells in type 2 diabetes are associated with glycemic control and endothelial dysfunction

(2018) Nagma Zafar et al.   PLoS One

N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

(2018) Nicole El-Darzi et al.   Frontiers in Pharmacology

Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells

(2018) Piul S. Rabbani et al.   DIABETES

Liver X receptors link lipid metabolism and inflammation

(2017) Ira G. Schulman   FEBS LETTERS

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor

(2017) Sandra S. Hammer et al.   EBioMedicine

Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils

(2016) Todd G. Kirchgessner et al.   Cell Metabolism

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Role of Acid Sphingomyelinase in Shifting the Balance Between Proinflammatory and Reparative Bone Marrow Cells in Diabetic Retinopathy

(2016) Harshini Chakravarthy et al.   STEM CELLS

Statin-Induced Decrease in ATP-Binding Cassette Transporter A1 Expression via microRNA33 Induction may Counteract Cholesterol Efflux to High-Density Lipoprotein

(2015) Eric J. Niesor et al.   CARDIOVASCULAR DRUGS AND THERAPY

Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis

(2015) Joseph B. Lin et al.   JOURNAL OF LIPID RESEARCH

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

(2015) Ayaka Ito et al.   eLife

A monophasic extraction strategy for the simultaneous lipidome analysis of polar and nonpolar retina lipids

(2014) Todd A. Lydic et al.   JOURNAL OF LIPID RESEARCH

Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments

(2014) Wenchao Zheng et al.   JOURNAL OF LIPID RESEARCH

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

The db/db Mouse: A Useful Model for the Study of Diabetic Retinal Neurodegeneration

(2014) Patricia Bogdanov et al.   PLoS One

Vasoreparative Dysfunction of CD34+ Cells in Diabetic Individuals Involves Hypoxic Desensitization and Impaired Autocrine/Paracrine Mechanisms

(2014) Yagna P. R. Jarajapu et al.   PLoS One

Cholesterol in the retina: The best is yet to come

(2014) Irina A. Pikuleva et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: Lack of compensation by LXRβ activation

(2013) Minako Ishibashi et al.   BIOCHEMICAL PHARMACOLOGY

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

(2013) Xin Rong et al.   Cell Metabolism

Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice

(2013) Monika Patel et al.   DIABETOLOGIA

Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin-Induced Diabetes

(2012) S. Hazra et al.   DIABETES

Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model

(2012) S. Hazra et al.   DIABETOLOGIA

Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis

(2012) Saida Omarova et al.   JOURNAL OF CLINICAL INVESTIGATION

Spatial Distribution of the Pathways of Cholesterol Homeostasis in Human Retina

(2012) Wenchao Zheng et al.   PLoS One

Synthetic LXR Agonist Suppresses Endogenous Cholesterol Biosynthesis and Efficiently Lowers Plasma Cholesterol

(2011) Thomas Pfeifer et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

(2011) J. K. Kruit et al.   DIABETES

Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation

(2011) Gaia Cermenati et al.   JOURNAL OF LIPID RESEARCH

Diabetes Impairs Hematopoietic Stem Cell Mobilization by Altering Niche Function

(2011) F. Ferraro et al.   Science Translational Medicine

Improved Function of Circulating Angiogenic Cells Is Evident in Type 1 Diabetic Islet-Transplanted Patients

(2010) A. Petrelli et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The ins and outs of cholesterol in the vertebrate retina

(2010) Steven J. Fliesler et al.   JOURNAL OF LIPID RESEARCH

Activation of the Liver X Receptor Increases Neuroactive Steroid Levels and Protects from Diabetes-Induced Peripheral Neuropathy

(2010) G. Cermenati et al.   JOURNAL OF NEUROSCIENCE

Effects of Medical Therapies on Retinopathy Progression in Type 2 Diabetes

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Low CD34+ cell count and metabolic syndrome synergistically increase the risk of adverse outcomes

(2009) Gian Paolo Fadini et al.   ATHEROSCLEROSIS

A new advanced glycation inhibitor, LR-90, prevents experimental diabetic retinopathy in rats

(2008) A Bhatwadekar et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering

(2008) Irina A Pikuleva   Expert Opinion on Drug Metabolism & Toxicology

Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia

(2008) Adelheid Kratzer et al.   JOURNAL OF LIPID RESEARCH

ent-Steroids: Novel tools for studies of signaling pathways

(2008) Douglas F. Covey   STEROIDS