BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation

(2019) Matthew S. Stratton et al.   CIRCULATION RESEARCH

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

(2018) Maria Kleppe et al.   CANCER CELL

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes

(2018) Delaine K. Ceholski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

(2018) Jean-Philippe Lambert et al.   MOLECULAR CELL

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

(2017) Ka Lung Cheung et al.   MOLECULAR CELL

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

(2017) Qiming Duan et al.   Science Translational Medicine

Developing New Treatments for Heart Failure

(2016) Mihai Gheorghiade et al.   Circulation-Heart Failure

Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy

(2016) Michael A. Burke et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

(2016) Onur Kanisicak et al.   Nature Communications

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA

(2016) Matthew S. Stratton et al.   Cell Reports

BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice

(2015) Y. Sun et al.   BLOOD

A study in Polish patients with cardiomyopathy emphasizes pathogenicity of phospholamban (PLN) mutations at amino acid position 9 and low penetrance of heterozygous null PLN mutations

(2015) Grażyna T Truszkowska et al.   BMC Medical Genetics

BET Bromodomains Regulate Transforming Growth Factor-β-induced Proliferation and Cytokine Release in Asthmatic Airway Smooth Muscle

(2015) Mark M. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

(2014) Jonathan D. Brown et al.   MOLECULAR CELL

Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription

(2014) Sankari Nagarajan et al.   Cell Reports

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

(2013) Priti Anand et al.   CELL

Bromodomain and Extraterminal (BET) Protein Inhibition Suppresses Human T Cell Leukemia Virus 1 (HTLV-1) Tax Protein-mediated Tumorigenesis by Inhibiting Nuclear Factor κB (NF-κB) Signaling

(2013) Xuewei Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BET acetyl-lysine binding proteins control pathological cardiac hypertrophy

(2013) Jessica I. Spiltoir et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

(2013) Z Zou et al.   ONCOGENE

Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy

(2013) R. Papait et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Regulation Patterns Revealed by High Resolution Chromatin Immunoprecipitation during Cardiac Hypertrophy

(2012) Danish Sayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiomyocyte-specific I B kinase (IKK)/NF- B activation induces reversible inflammatory cardiomyopathy and heart failure

(2012) H. J. Maier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Brd4 Coactivates Transcriptional Activation of NF- B via Specific Binding to Acetylated RelA

(2008) B. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Cardiac Plasticity

(2008) Joseph A. Hill et al.   NEW ENGLAND JOURNAL OF MEDICINE