Exploring the Effect of Esomeprazole on Gastric and Duodenal Fluid Volumes and Absorption of Ritonavir

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

(2020) Marival Bermejo et al.   Pharmaceutics

Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib

(2020) Neil Parrott et al.   AAPS Journal

The effect of reduced gastric acid secretion on the gastrointestinal disposition of a ritonavir amorphous solid dispersion in fasted healthy volunteers: an in vivo - in vitro investigation.

(2020) Jens Van Den Abeele et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Biorelevant two-stage in vitro testing for rDCS classification and in PBPK modelling – Case example ritonavir

(2020) Tom Fiolka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Impact of Acid-Reducing Agents on Gastrointestinal Physiology and Design of Biorelevant Dissolution Tests to Reflect These Changes

(2019) Domagoj Segregur et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Interindividual and intraindividual variability of fasted state gastric fluid volume and gastric emptying of water

(2018) Michael Grimm et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects

(2018) Michael Grimm et al.   MOLECULAR PHARMACEUTICS

Prediction of ARA/PPI Drug-Drug Interactions at the Drug Discovery and Development Interface

(2018) Stephanie Dodd et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus™

(2018) Bart Hens et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro–In Silico–In Vivo Approach: Case Examples—Dipyridamole, Prasugrel, and Nelfinavir

(2018) Atsushi Kambayashi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

25 Years of Proton Pump Inhibitors: A Comprehensive Review

(2017) Daniel S. Strand et al.   Gut and Liver

Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs: a Case Study with Nifedipine

(2016) Ahmed M. Nader et al.   AAPS Journal

Inappropriate use of proton pump inhibitors in elderly patients discharged from acute care hospitals

(2015) R. Schepisi et al.   Journal of Nutrition Health & Aging

Proton Pump Inhibitors Inhibit Pancreatic Secretion: Role of Gastric and Non-Gastric H+/K+-ATPases

(2015) Jing Wang et al.   PLoS One

Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors: An Update

(2014) Ralph-Steven Wedemeyer et al.   DRUG SAFETY

Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State

(2014) Deanna M. Mudie et al.   MOLECULAR PHARMACEUTICS

Effect of meal and antisecretory agents on the pharmacokinetics of danoprevir/ritonavir in healthy volunteers

(2013) Peter N. Morcos et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Assessing the performance of amorphous solid dispersions

(2011) Ann Newman et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Role of Physiological Intestinal Water in Oral Absorption

(2009) Steven C. Sutton   AAPS Journal

Effect of proton pump inhibition on the gastric volume: assessed by magnetic resonance imaging

(2009) A. BABAEI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A comparison of the acid-inhibitory effects of esomeprazole and pantoprazole in relation to pharmacokinetics and CYP2C19 polymorphism

(2009) N. G. HUNFELD et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effect of Proton Pump Inhibitors on Gastric Juice Volume, Gastric pH and Gastric Intramucosal pH in Critically Ill Patients

(2008) Olcay Gursoy et al.   CLINICAL DRUG INVESTIGATION