Article
Oncology
Evgenii Belykh, Liudmila Bardonova, Irakliy Abramov, Vadim A. A. Byvaltsev, Talgat Kerymbayev, Kwanha Yu, Debbie R. R. Healey, Ernesto Luna-Melendez, Benjamin Deneen, Shwetal Mehta, James K. K. Liu, Mark C. C. Preul
Summary: Surgical resection is the primary treatment for gliomas, but there is a lack of comparative effectiveness information for different fluorescent dyes used for intraoperative tumor visualization. This study analyzed the effectiveness of fluorescein sodium (FNa), 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX), and indocyanine green (ICG) fluorescence in various glioma models and found that wide-field imaging is equally efficient for highly malignant gliomas with all three dyes, while confocal microscopy improves diagnostic accuracy and can better detect low concentrations of PpIX and FNa in low-intermediate grade gliomas.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Jens Osterkamp, Rune B. Strandby, Nikolaj Nerup, Morten Bo Sondergaard Svendsen, Lars Bo Svendsen, Michael Patrick Achiam
Summary: ICG lymphography significantly increased the number of resected lymph nodes in oncological gastric surgery. Intraoperative injections of ICG could be a sufficient alternative to preoperative injections due to the short time until maximum ICG fluorescence of sentinel lymph nodes. Combined ICG and SF lymphography was feasible and resulted in clear lymphograms with no interference between the two dyes, offering the exciting prospect of simultaneously assessing perfusion and performing fluorescence lymphography.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Review
Oncology
Andrea Bianconi, Marta Bonada, Pietro Zeppa, Stefano Colonna, Fulvio Tartara, Antonio Melcarne, Diego Garbossa, Fabio Cofano, Andreas F. Hottinger, Nimish Mohile
Summary: This systematic review aimed to evaluate the reliability of fluorescence-guided surgery in low-grade gliomas and identify the best fluorophore for highlighting tumor boundaries. The current evidence does not support the routine use of 5-aminolevulinic acid or sodium fluorescein in low-grade glioma surgery. New molecules and techniques show promising results but require further clinical validation.
Review
Biochemical Research Methods
Brian W. Pogue, Eben L. Rosenthal
Summary: The modern use of fluorescence in surgery was facilitated by regulatory approvals and device clearances, leading to a growing set of surgery subspecialty uses. Key milestones in commercially marketed systems and agents were outlined, with a focus on temporal sequences and strategic decisions to inform future successes. Successful regulatory approvals for fluorescent imaging agents and open surgery imaging devices have paved the way for growth and adoption in surgical subspecialties.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Otorhinolaryngology
Nitish Khurana, Eric Babajanian, Hilary McCrary, Abigail Pulsipher, Hamidreza Ghandehari, Jeremiah A. A. Alt, Richard B. B. Cannon
Summary: This study evaluated the use of indocyanine green (ICG) in FI-guided transoral robotic surgery (TORS) and its underlying molecular mechanism. The results showed that ICG accumulation increased significantly in primary tumors and pathological lymph nodes. IVIS accurately identified oropharyngeal squamous cell carcinoma (OPSCCa) in excised tissues, and genes associated with vascular and angiogenic signaling pathways were upregulated in OPSCCa tissues.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Neurosciences
Jun Muto, Yutaka Mine, Yuya Nishiyama, Kazuhiro Murayama, Seiji Yamada, Daijiro Kojima, Motoharu Hayakawa, Kazuhide Adachi, Mitsuhiro Hasegawa, John Y. K. Lee, Yuichi Hirose
Summary: This study aimed to visualize meningiomas and dural tails intraoperatively using delayed-window indocyanine green (ICG) technique. The results showed that NIR fluorescence could accurately identify meningiomas and was correlated with MRI findings and blood-brain barrier permeability. DWIG had high sensitivity and positive predictive value in tumor identification.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Zoe Garoufalia, Steven D. D. Wexner
Summary: ICG imaging is increasingly used in colorectal surgery for perfusion assessment, ureteral and urethral assessment, lymphatic mapping, and assessment of hepatic and peritoneal metastases. Although evidence level is low, promising results have been observed, especially in reducing anastomotic leaks. ICG imaging is a safe and relatively cheap imaging modality in colorectal surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Jinghua Li, Xiaomian Li, Xiao Zhang, Haitao Wang, Kun Li, Yueming He, Zhisu Liu, Zhonglin Zhang, Yufeng Yuan
Summary: The study evaluated the safety and effectiveness of ICG fluorescence imaging-guided laparoscopic right posterior hepatectomy, showing that ICG fluorescence imaging guidance could be helpful for the safe implementation of the surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Clinical Neurology
Ibrahem Albalkhi, Areez Shafqat, Othman Bin-Alamer, Abdul Rahman Abou Al-Shaar, Arka N. Mallela, Ricardo J. Fernandez-de Thomas, Pascal O. Zinn, Peter C. Gerszten, Constantinos G. Hadjipanayis, Hussam Abou-Al-Shaar
Summary: This meta-analysis examines the efficacy of fluorescence guidance in intradural spinal tumor resection. The results show that meningiomas and ependymomas have the highest fluorescence rates, especially with sodium fluorescein. Astrocytomas have variable fluorescence rates with no superiority of either agent. Positive fluorescence of intramedullary tumors is associated with a higher degree of resection.
NEUROSURGICAL REVIEW
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rashi Mehta, Jeffrey S. Carpenter, Rupal Mehta, Marc W. Haut, Manish Ranjan, Umer Najib, Paul Lockman, Peng Wang, Pierre-Francois D'haese, Ali R. Rezai
Summary: The study demonstrated the safety of MRI-guided focused ultrasound-induced blood-brain barrier opening in participants with early AD, with a unique spatiotemporal contrast enhancement pattern suggesting a perivenular immunologic healing response downstream from targeted sites.
Review
Clinical Neurology
Emily J. Smith, Kavita Gohil, Charee M. Thompson, Anant Naik, Wael Hassaneen
Summary: This meta-analysis demonstrates that fluorescein-guided surgery improves GTR rates of HGGs compared to non-fluorescence guided surgery, while showing similar GTR rates compared to reported 5-ALA-guided resection rates.
WORLD NEUROSURGERY
(2021)
Article
Gastroenterology & Hepatology
Hong-min Ahn, Gyung Mo Son, In Young Lee, Sang-Ho Park, Nam Su Kim, Kwang-Ryul Baek
Summary: This study aimed to evaluate the extrinsic effects of conditional factors affecting quantitative parameters in ICG angiography, and to establish the optimization through in vitro experiments and a prospective observational study. The study found that various conditional factors such as camera distance, fluorescence emission source, and ICG mode significantly influenced the quantitative parameters of ICG angiography. Standardized protocols, such as using ICG specific modes with a constant distance of 4-5 cm, were recommended to provide optimized fluorescence images.
COLORECTAL DISEASE
(2021)
Review
Pharmacology & Pharmacy
Qi-Jia Duan, Zhong-Yi Zhao, Yao-Jun Zhang, Liangbing Fu, You-Yong Yuan, Jin-Zhi Du, Jun Wang
Summary: Surgery and drug therapy are hindered by difficulties in accurate tumor location and timely monitoring of drug efficacy, but rapid development of imaging techniques, particularly fluorescence imaging, provides promising tools to address these challenges. Fluorescent probes, especially site-specifically activatable nanoprobes, have been developed and explored for tumor diagnosis and treatment monitoring. This review discusses recent advances in fluorescent probes and highlights the potential implementation of activatable nanoprobes in fluorescence imaging-guided surgery and imaging-guided drug therapy.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Clinical Neurology
Jun Muto, Yutaka Mine, Yuya Nishiyama, Kazuhiro Murayama, Motoharu Hayakawa, Mitsuhiro Hasegawa, John K. Y. Lee, Yuichi Hirose
Summary: This study assessed the use of the ICG technique in pituitary tumor surgery to identify tumors in real-time and analyze the mechanism of ICG fluorescence in the pituitary gland and tumor.
WORLD NEUROSURGERY
(2023)
Article
Obstetrics & Gynecology
Xi Wang, Yan Zhang, Huixia Yang, Yang Xu
Summary: ICG transfer from mother to fetus is slow and safe during pregnancy, with minimal accumulation in the fetus due to effective placental barrier. Adverse reactions to ICG are rare, with concerns mainly related to teratogenicity or lawsuits.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Clinical Neurology
Vadim A. Byvaltsev, Andrei A. Kalinin, Marat A. Aliyev, K. Daniel Riew
Summary: This study is a prospective non-randomized single-center cohort study aiming to analyze the quality of postoperative magnetic resonance imaging (MRI) of two structurally different cervical disc arthroplasty devices. The study found that patients with titanium prostheses had superior postoperative MRI images compared to those with cobalt chromium implants, as cobalt chromium significantly reduced image quality due to its pronounced ferromagnetic effect.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Vadim A. Byvaltsev, Andrei A. Kalinin, Marat A. Aliyev, Valerii V. Shepelev, Yurii Ya Pestryakov, Marcel Ivanov
Summary: Professional athletes undergoing lumbar total disc replacement with the M6-L prosthesis showed significant reduction in pain, improvement in function, and early return to sports activities. Postoperatively, they maintained segmental range of motion and avoided significant degenerative changes in adjacent levels.
WORLD NEUROSURGERY
(2021)
Article
Medicine, Research & Experimental
V. V. Kanygin, A. Kasatova, E. L. Zavjalov, I. A. Razumov, S. Kolesnikov, A. Kichigin, O. Solov'eva, A. R. Tsygankova, S. Yu Taskaev, D. A. Kasatov, T. Sycheva, V. A. Byvaltsev
Summary: This study evaluated the effectiveness of BNCT in treating malignant neoplasms of the rectum and colon. The results showed that BNCT treatment with BPA and BSH injections significantly decreased tumor volumes.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Orthopedics
Ward Shalash, Sonia R. Ahrens, Liudmila A. Bardonova, Vadim A. Byvaltsev, Morgan B. Giers
Summary: The study utilized MRI data to model gradients of nutrients in intervertebral discs and found that as degeneration progressed, nutrient levels decreased and acidity levels increased. Individual disc morphology and physiological conditions should be considered when modeling nutrient concentrations in the disc.
Article
Clinical Neurology
Vadim A. Byvaltsev, Andrei A. Kalinin, Valerii V. Shepelev, Yurii Ya Pestryakov, Mikhail Y. Biryuchkov, Bagdat A. Jubaeva, Venkat Boddapati, Ronald A. Lehman, K. Daniel Riew
Summary: This study conducted a pathomorphological analysis of facet joint degeneration using cadaveric specimens and correlated the findings with imaging results. The study found a direct association between facet joint degeneration and patient age, as well as a decrease in articular cartilage cell density with increasing patient age. Additionally, there was a significant correlation between radiographic degenerative changes in facet joints and both the age and morphological classification of the cadavers, as well as an inverse correlation with cell density. These findings may be valuable for surgeons in guiding therapeutic strategies based on individual biometric parameters of the facet joints.
GLOBAL SPINE JOURNAL
(2022)
Article
Surgery
Maxim N. Kravtsov, Vadim A. Manukovsky, Gennadiy G. Bulyshchenko, Saidmirze D. Mirzametov, Vadim A. Byvaltsev
Summary: The study described three clinical cases of using full-endoscopic surgery to treat gunshot wounds to the spine, showing good clinical outcomes and recommending its use for similar lumbar and thoracic spine gunshot wounds.
FRONTIERS IN SURGERY
(2022)
Article
Clinical Neurology
Vadim A. Byvaltsev, Andrei A. Kalinin, Valerii V. Shepelev, Yurii Ya Pestryakov, Marat A. Aliyev, K. Daniel Riew
Summary: This retrospective study compared the clinical efficacy and postoperative MRI results of minimally invasive (MI) and open (O) transforaminal lumbar interbody fusion (TLIF) in the treatment of cauda equina syndrome (CES) caused by lumbar disc herniation. The results showed that MI-TLIF had better perioperative outcomes and long-term clinical results compared to O-TLIF.
WORLD NEUROSURGERY
(2022)
Review
Biochemistry & Molecular Biology
Vadim A. Byvaltsev, Andrei A. Kalinin, Phillip A. Hernandez, Valerii V. Shepelev, Yurii Y. Pestryakov, Marat A. Aliyev, Morgan B. Giers
Summary: Spinal stenosis is a condition characterized by the narrowing of the spinal canal, and it has multiple genetic and molecular mechanisms. Ossification of the posterior longitudinal ligament, facet joint osteoarthritis, hypertrophy and ossification of the ligamentum flavum, intervertebral disc herniation, and achondroplasia are the main mechanisms of spinal stenosis. Further studies are needed to understand the genetic and molecular changes associated with this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Orthopedics
Vadim Byvaltsev, Roman Polkin, Andrei Kalinin, Maxim Kravtsov, Evgenii Belykh, Valerii Shepelev, Elmira Satardino, Vadim Manukovsky, K. Daniel Riew
Summary: This study aimed to compare the safety and efficacy of laminoplasty (LP) and laminectomy (LE) for adult patients with primary spinal cord tumors (PSCTs). LP is not widely used in the neurosurgical community, despite its advantages. The efficacy of LP vs. LE remains controversial. A total of seven observational studies with 540 patients were included. There were no significant differences in operation time and complications between LP and LE groups. The LP group had a shorter hospital stay and lower postoperative spinal deformity rate compared to the LE group. However, these findings are limited by the low quality of available evidence, and further randomized controlled trials are needed for comparison.
ASIAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Vadim A. Byvaltsev, Andrei A. Kalinin, Evgenii G. Belykh, Marat A. Aliyev, Bair B. Sanzhin, Alexander V. Kukharev, Yermek K. Dyussembekov, Valerii V. Shepelev, K. Daniel Riew
Summary: The study evaluated the clinical and radiological outcomes of treating three-column uncomplicated type B subaxial injuries with one-level cervical corpectomy and an expandable cage. The results showed improvement in pain scores, NDI scores, and excellent/good outcomes according to Macnab's scale. However, the fusion rate was low, and complications were relatively high. The study concluded that while the procedure offers immediate stability and decompression, it has limitations in terms of fusion and complications.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Vadim A. Byvaltsev, Roman A. Polkin, Andrei A. Kalinin, Evgenii Belykh, K. Daniel Riew
Summary: The new laminar reconstruction technique combines laminectomy with reconstruction to effectively treat primary spinal cord tumors, providing maximum exposure and manipulation of the tumor while preserving spinal biomechanics.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Evgenii Belykh, Irakliy Abramov, Liudmila Bardonova, Ruchi Patel, Sarah McBryan, Lara Enriquez Bouza, Neil Majmundar, Xiaochun Zhao, Vadim A. Byvaltsev, Stephen A. Johnson, Amit Singla, Gaurav Gupta, Hai Sun, James K. Liu, Anil Nanda, Mark C. Preul, Michael T. Lawton
Summary: The study developed 7 simulation bypass scenarios using 3D printed skull models and silicone molds, accurately replicating narrow surgical corridors and hand positions. Experienced neurosurgeons confirmed the face and content validity of the models and suggested that practicing with these models may improve bypass technique.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Vadim A. A. Byvaltsev, Victoria Yu. Goloborodko, Andrei A. A. Kalinin, Valerii V. V. Shepelev, Yurii Ya. Pestryakov, K. Daniel Riew
Summary: The objective of this study was to improve the results of lumbar spine surgery in high-risk patients. A neuroanesthetic protocol with multimodal analgesia was compared to intravenous anesthesia based on propofol and fentanyl. The study group showed better cognitive functions, lower opioid drug use, and less incisional pain. Adverse anesthesia effects were also significantly lower in the study group. Long-term clinical results were improved in the study group compared to the control group.
NEUROSURGICAL REVIEW
(2023)
Article
Clinical Neurology
Vadim A. Byvaltsev, Andrei A. Kalinin, Marat A. Aliyev, Bakhyt M. Aglakov, Alexander V. Kuharev, Nurzhan O. Azhibekov
Summary: This study analyzed the effectiveness of an algorithmic anterior approach in the surgical treatment of patients with two-level cervical degenerative disk disease based on preoperative clinical and imaging parameters. The results showed that the algorithmic anterior approach significantly improved functional outcomes and decreased complications at a minimum 2-year follow-up period.
NEUROSURGICAL REVIEW
(2023)
Article
Sport Sciences
V. A. Byvaltsev, A. A. Kalinin, A. K. Okoneshnikova, M. Yu. Biryuchkov
Summary: The paper aims to analyze the clinical efficacy of PRP therapy for the treatment of isolated lumbar facet syndrome in professional team sports athletes. The study showed that PRP therapy provides a stable reduction in lumbar pain, quick functional recovery, and a low incidence of complications.
HUMAN SPORT MEDICINE
(2022)