What Have In Vitro Co-Culture Models Taught Us about the Contribution of Epithelial-Mesenchymal Interactions to Airway Inflammation and Remodeling in Asthma?

Asthmatic Bronchial Smooth Muscle Increases CCL5-Dependent Monocyte Migration in Response to Rhinovirus-Infected Epithelium

(2020) Benoit Allard et al.   Frontiers in Immunology

Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma

(2020) Emmanuel T. Osei et al.   Scientific Reports

Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma

(2019) Leila B Mostaço-Guidolin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nascent Lung Organoids Reveal Epithelium- and BMP-Mediated Suppression of Fibroblast Activation

(2019) Qi Tan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Multivascular networks and functional intravascular topologies within biocompatible hydrogels

(2019) Bagrat Grigoryan et al.   SCIENCE

3D bioprinting for lungs and hollow organs

(2019) Zachary Galliger et al.   Translational Research

The Role of Airway Myofibroblasts in Asthma

(2019) Nicholas G. Jendzjowsky et al.   CHEST

Budesonide enhances agonist-induced bronchodilation in human small airways by increasing cAMP production in airway smooth muscle

(2019) Cynthia J. Koziol-White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Current perspectives on the role of Interleukin-1 signaling in the pathogenesis of Asthma and COPD

(2019) Emmanuel T. Osei et al.   EUROPEAN RESPIRATORY JOURNAL

Equine bronchial fibroblasts enhance proliferation and differentiation of primary equine bronchial epithelial cells co-cultured under air-liquid interface

(2019) Vanessa Abs et al.   PLoS One

Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond

(2018) Kambez H. Benam et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Therapeutic Role for TSP-2 Antibody in a Murine Asthma Model

(2018) Kai Li et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Airway epithelial compression promotes airway smooth muscle proliferation and contraction

(2018) Bo Lan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TGF-β Signaling in Lung Health and Disease

(2018) Akira Saito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fibroblast gene expression following asthmatic bronchial epithelial cell conditioning correlates with epithelial donor lung function and exacerbation history

(2018) Stephen R. Reeves et al.   Scientific Reports

Functional characterization of a novel 3D model of the epithelial-mesenchymal trophic unit

(2017) Fabio Bucchieri et al.   EXPERIMENTAL LUNG RESEARCH

Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases

(2017) Tinne C.J. Mertens et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD

(2016) Emmanuel T. Osei et al.   EUROPEAN RESPIRATORY JOURNAL

Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology

(2016) Ramaswamy Krishnan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mono- and Cocultures of Bronchial and Alveolar Epithelial Cells Respond Differently to Proinflammatory Stimuli and Their Modulation by Salbutamol and Budesonide

(2015) Mehra Haghi et al.   MOLECULAR PHARMACEUTICS

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Monocyte-derived fibrocytes induce an inflammatory phenotype in airway smooth muscle cells

(2014) T.-Y. Lin et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components

(2014) Stephen R. Reeves et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-1β Attenuates Myofibroblast Formation and Extracellular Matrix Production in Dermal and Lung Fibroblasts Exposed to Transforming Growth Factor-β1

(2014) Masum M. Mia et al.   PLoS One

Brain Natriuretic Peptide Protects against Hyperresponsiveness of Human Asthmatic Airway Smooth Muscle via an Epithelial Cell–Dependent Mechanism

(2013) Luigino Calzetta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts

(2013) M I Suwara et al.   Mucosal Immunology

Human Mesenchymal Stem Cells Suppress the Stretch–Induced Inflammatory miR-155 and Cytokines in Bronchial Epithelial Cells

(2013) Yi-Chun Kuo et al.   PLoS One

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pro-inflammatory and immunomodulatory functions of airway smooth muscle: Emerging concepts

(2012) Yuxiu C. Xia et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Regulation of epithelial cell proliferation by bronchial fibroblasts obtained from mild asthmatic subjects

(2010) A. Semlali et al.   ALLERGY

Epithelial repair mechanisms in the lung

(2010) Lynn M. Crosby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling

(2010) J. R. Rock et al.   Disease Models & Mechanisms

Airway Epithelium Stimulates Smooth Muscle Proliferation

(2009) Nikita K. Malavia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathogenesis of Asthma

(2008) STEPHEN T. HOLGATE   CLINICAL AND EXPERIMENTAL ALLERGY

Fibrocyte localization to the airway smooth muscle is a feature of asthma

(2008) Ruth Saunders et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The cytokine network in asthma and chronic obstructive pulmonary disease

(2008) Peter J. Barnes   JOURNAL OF CLINICAL INVESTIGATION