Article
Hematology
Axel Rosell, Gargi Gautam, Fredrika Wannberg, Henry Ng, Hanna Gry, Emma Vingback, Staffan Lundstrom, Nigel Mackman, Hakan Wallen, Eli Westerlund, Charlotte Thalin
Summary: This study found that H3Cit-DNA is an independent predictor for occult cancer in patients with VTE and is elevated in cancer-associated VTE. This suggests that H3Cit-DNA may be a useful diagnostic marker for cancer in patients with VTE and that elevated NET formation is a hallmark of cancer-associated VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Peder Wiklund, Koshiar Medson, Johan Elf
Summary: This study assessed the risk of recurrent venous thromboembolism (VTE) and death in patients with unreported cancer-associated incidental pulmonary embolism (iPE). The results showed that the extent of iPE burden was associated with the risk of recurrent VTE, but a single subsegmental iPE was not associated with the risk of recurrent VTE. There were no significant associations between iPE burden and risk of death.
THROMBOSIS RESEARCH
(2023)
Article
Hematology
Inge A. Gimbel, Frits I. Mulder, Floris T. M. Bosch, Jan Erik Freund, Noori Guman, Nick van Es, Pieter W. Kamphuisen, Harry R. Buller, Saskia Middeldorp
Summary: The study found that 12.4% of cancer patients had pulmonary embolism at autopsy, with 90.2% being thrombotic embolism. Venous thromboembolism occurred in 12.8% of the patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Ella Grilz, Florian Posch, Stephan Nopp, Oliver Koenigsbruegge, Irene M. Lang, Peter Klimek, Stefan Thurner, Ingrid Pabinger, Cihan Ay
Summary: Patients with cancer have a significantly higher risk of both arterial thromboembolism (ATE) and venous thromboembolism (VTE) compared to those without cancer. Different types of cancer show variations in the incidence of ATE and VTE.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ella Grilz, Florian Posch, Stephan Nopp, Oliver Konigsbrugge, Irene M. Lang, Peter Klimek, Stefan Thurner, Ingrid Pabinger, Cihan Ay
Summary: This study in Austria found a significantly higher risk of arterial and venous thrombosis in cancer patients using International Classification of Disease 10th Revision (ICD-10) diagnosis codes, indicating a strong association between cancer, ATE, and VTE.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Jonathan Yugo Maesaka, Yedda Nunes Reis, Livia Menezes Elias, Denise Akerman, Edmund Chada Baracat, Jose Roberto Filassi
Summary: The aim of this study was to determine the frequency of VTE in breast cancer patients undergoing surgery and identify the related risk factors. The study found that 0.9% of patients experienced VTE events, with 0.2% being deep vein thrombosis and 0.7% being pulmonary thromboembolism. Immediate reconstruction, especially with abdominal-based flaps, and longer surgical time were associated with increased risk of VTE. Postoperative prophylaxis with LMWH reduced this risk.
Review
Oncology
Salah Eddine Ousama Kacimi, Aysan Moeinafshar, Shirin Shahsavar Haghighi, Amene Saghazadeh, Nima Rezaei
Summary: VTE is a clinical disease that frequently occurs in cancer patients, and immunotherapy, although effective for cancer treatment, can also increase the risk of VTE.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Hematology
Rayna J. S. Anijs, Yen Nhi Nguyen, Suzanne C. Cannegieter, Henri H. Versteeg, Jeroen T. Buijs
Summary: MicroRNAs (miRNAs) are small noncoding RNAs with gene regulatory functions that can serve as promising biomarkers for the diagnosis and prediction of cancer and cardiovascular diseases. They play important roles in regulating the pathophysiology of venous thromboembolism (VTE) and cancer-associated thrombosis (CAT). Validation studies using comparable patient populations are needed to determine the potential use of miRNAs as standalone or incorporated biomarkers in risk prediction models for VTE and CAT.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Oncology
Jasmin Jo, Maria Diaz, Craig Horbinski, Nigel Mackman, Stephen Bagley, Marika Broekman, Janusz Rak, James Perry, Ingrid Pabinger, Nigel S. Key, David Schiff
Summary: Patients with diffuse glioma have a high risk of developing venous thromboembolism (VTE), especially those with glioblastoma. Efforts are being made to identify biomarkers that can predict the increased risk of VTE, but there is currently no established prophylactic treatment. Therapeutic anticoagulation with LMWH or DOACs is recommended for VTE treatment, but the risk of intracranial hemorrhage in glioblastoma patients makes anticoagulation challenging. Investigational anticoagulants that prevent thrombosis without impairing hemostasis may offer a better therapeutic option.
Article
Medicine, General & Internal
Orly Efros, Tal Beit Halevi, Eshcar Meisel, Shelly Soffer, Noam Barda, Omri Cohen, Gili Kenet, Aharon Lubetsky
Summary: An elevated NLR in patients hospitalized with acute PE is associated with increased short-term and long-term mortality risk, longer hospital stays, and higher in-hospital mortality rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Samantha M. Rizzo, Sherwin Tavakol, Wenya Linda Bi, Siling Li, Eric A. Secemsky, Umberto Campia, Gregory Piazza, Samuel Z. Goldhaber, Alec A. Schmaier
Summary: The study aimed to determine the incidence of VTE following meningioma resection and its relationship with the type and timing of anticoagulation. The cumulative incidence of postoperative VTE was 8.7%, and the incidence of symptomatic VTE was 6.0%. Independent predictors of symptomatic VTE were history of VTE, obesity, and lack of pharmacologic prophylaxis. Most VTE patients ultimately received therapeutic anticoagulation.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Anne Gulbech Ording, Flemming Skjoth, Mette Sogaard, Anette Arbjerg Hojen, Thure Filskov Overvad, Simon Noble, Samuel Zachary Goldhaber, Torben Bjerregaard Larsen
Summary: A study in Denmark found an increasing incidence of venous thromboembolism after a first primary cancer diagnosis from 2006 to 2017, but a declining trend in 30-day and 1-year mortality rates following venous thromboembolism. This decrease in mortality was consistent across different cancer stages, types, and treatments.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peder Wiklund, Koshiar Medson, Johan Elf
Summary: This study assessed the prevalence of reported and unreported incidental pulmonary embolism (iPE) in cancer patients and evaluated the use of an artificial intelligence algorithm for automatic detection of iPE. The results showed that a majority of iPE cases were unreported, and the AI algorithm demonstrated high sensitivity and specificity in detecting iPE.
EUROPEAN RADIOLOGY
(2023)
Article
Hematology
Patricia Siguenza, Juan J. Lopez-Nunez, Conxita Falga, Covadonga Gomez-Cuervo, Antoni Riera-Mestre, Aida Gil-Diaz, Peter Verhamme, Ana Cristina Montenegro, Cristina Barbagelata, Egidio Imbalzano, Manuel Monreal
Summary: This study compared the effectiveness of enoxaparin monotherapy in cancer patients with renal insufficiency using the RIETE registry. The results showed that the incidence of fatal PE was higher than fatal bleeding in patients with severe renal insufficiency receiving recommended doses of enoxaparin.
THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Hematology
Megan Purdy, Andrea Obi, Daniel Myers, Thomas Wakefield
Summary: Venous thromboembolism (VTE) is a common and costly health problem worldwide. Current anticoagulant treatments have limitations in terms of bleeding risks and prevention of post-thrombotic syndrome or chronic thromboembolic pulmonary hypertension. Inhibition of selectins, a family of glycoproteins that modulate thrombosis, has shown promise as a potential therapy for VTE, with the ability to decrease thrombosis and vein wall fibrosis without increasing bleeding risks.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Martina Giambra, Andrea Di Cristofori, Donatella Conconi, Matilde Marzorati, Serena Redaelli, Melissa Zambuto, Alessandra Rocca, Louis Roumy, Giorgio Carrabba, Marialuisa Lavitrano, Gaia Roversi, Carlo Giussani, Angela Bentivegna
Summary: Despite efforts made, glioblastoma remains a deadly primary brain cancer with no cure. The peritumoural brain zone (PBZ), the apparently normal area surrounding the tumour, has shown potential in the tumour's maintenance and progression. This study aims to better understand PBZ and identify genes that may play a role in its malignant transformation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Maria P. Fernandez-Perez, Enrique Perez-Navarro, Teresa Alonso-Gordoa, Vicenza Conteduca, Albert Font, Sergio Vazquez-Estevez, Aranzazu Gonzalez-del-Alba, Daniel Wetterskog, Emmanuel S. Antonarakis, Begona Mellado, Ovidio Fernandez-Calvo, Maria J. Mendez-Vidal, Miguel A. Climent, Ignacio Duran, Enrique Gallardo, Angel Rodriguez Sanchez, Carmen Santander, Maria Saez, Javier Puente, Julian Tudela, Alberto Martinez, Maria J. Lopez-Andreo, Jose Padilla, Rebeca Lozano, David Hervas, Jun Luo, Ugo de Giorgi, Daniel Castellano, Gerhardt Attard, Enrique Grande, Enrique Gonzalez-Billalabeitia
Summary: This study investigated the prognostic value of multiple biomarkers in the treatment response and survival outcomes of castration-resistant prostate cancer patients. The study found that circulating tumor cells and plasma androgen receptor gain were the most relevant biomarkers.
Article
Biochemistry & Molecular Biology
Paula Gonzalez-Jimenez, Raul Mendez, Ana Latorre, Monica Piqueras, Maria Nieves Balaguer-Cartagena, Antonio Moscardo, Ricardo Alonso, David Hervas, Soledad Reyes, Rosario Menendez
Summary: The role of NETs and platelet activation in COVID-19 is not well known. This study aimed to evaluate their impact on clinical trajectories. The levels of cfDNA, CitH3, and P-selectin were found to be associated with disease severity and analytical parameters. Higher levels of CitH3 and P-selectin increased the risk of transitioning from the emergency department to the ICU, while higher levels of P-selectin increased the risk of transitioning from the ward to death. Elevated levels of CitH3, cfDNA, and P-selectin decreased the probability of transitioning from the ward to discharge. These findings suggest that NETs and P-selectin levels can be useful in predicting different clinical trajectories.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Maria Castano, Eva Gonzalez-Canto, Cristina Aghababyan, Sarai Tomas-Perez, Julia Oto, Raquel Herranz, Pilar Medina, Martin Goette, Barbara Andrea Mc Cormack, Josep Mari-Alexandre, Juan Gilabert-Estelles
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Castano, Sarai Tomas-Perez, Eva Gonzalez-Canto, Cristina Aghababyan, Andrea Mascaros-Martinez, Nuria Santonja, Alejandro Herreros-Pomares, Julia Oto, Pilar Medina, Martin Goette, Barbara Andrea Mc Cormack, Josep Mari-Alexandre, Juan Gilabert-Estelles
Summary: Neutrophils play a crucial role in defense against pathogens through various mechanisms, including the release of neutrophil extracellular traps (NETs). These NETs, composed of DNA, histones, and other molecules, have been implicated in both immune defense and the progression of diseases like cancer. In this review, the focus is on ovarian cancer (OC), exploring the involvement of NETs in metastasis establishment and progression, as well as their role in therapy resistance. Additionally, the potential of NETs as diagnostic and prognostic markers for OC is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Herreros-Pomares, David Hervas, Leticia Bagan-Debon, Eloisa Jantus-Lewintre, Concepcion Gimeno-Cardona, Jose Bagan
Summary: This study aims to compare and describe the composition and diversity of the oral microbiome in patients with homogeneous leucoplakia, proliferative verrucous leukoplakia, oral squamous cell carcinoma, and OSCC preceded by PVL. The number of bacterial species was lower in cancer patients, with Fusobacteriota being the dominant group. PVL and PVL-OSCC patients had a higher abundance of Campilobacterota and lower Proteobacteria compared to other groups. This is the first study comparing oral microbiome alterations in these groups, and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alejandro Herreros-Pomares, David Hervas, Leticia Bagan-Debon, Alex Proano, Diana Garcia, Juan Sandoval, Jose Bagan
Summary: This study investigated the pathophysiologic differences between proliferative verrucous leukoplakia-associated oral squamous cell carcinoma (PVL-OSCC) and non-PVL-OSCC through transcriptomic and DNA methylation analyses. The results showed that PVL-OSCC patients had lower expression of cancer-related genes and hypermethylation of the promoter region of many genes, suggesting that DNA methylation could be a regulatory mechanism.
Article
Multidisciplinary Sciences
Nestor J. Martinez-Hernandez, Lara Milian-Medina, Jorge Mas-Estelles, Jose L. Monroy-Anton, Jose L. Lopez-Villalobos, David Hervas-Marin, Amparo Roig-Bataller, Manuel Mata-Roig
Summary: This study investigates the effect of an escalated radiation dose on decellularized rabbit trachea. It determines that a dose of 1 kGy achieves complete sterility without significant histological and biomechanical changes in the organ.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Medicine, General & Internal
Laura Agullo, Javier Muriel, Cesar Margarit, Monica Escorial, Diana Garcia, Maria Jose Herrero, David Hervas, Juan Sandoval, Ana M. Peiro
Summary: This study explores the sex differences in analgesic response attributed to DNA methylation changes and genetic variants in OPRM1 and COMT genes. It demonstrates significant sex differences related to OPRM1 signaling efficiency and the risk of opioid use disorder. These findings emphasize the importance of considering sex as a biological variable in chronic pain management studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Andrea Urtasun, Gladys G. Olivera, Luis Sendra, Salvador F. Alino, Pablo Berlanga, Pablo Gargallo, David Hervas, Julia Balaguer, Antonio Juan-Ribelles, Maria del Mar Andres, Adela Canete, Maria Jose Herrero
Summary: Cancer is the leading cause of death in pediatric populations, and this study aims to identify genetic variants that impact treatment safety and efficacy. 64 infant patients were genotyped, and associations were found between genetic variants and survival and hematological toxicity. Personalized medicine based on these findings could improve response and tolerance to chemotherapy.
Review
Oncology
Julia Oto, Quang-Khoi Le, Sebastian D. Schaefer, Ludwig Kiesel, Josep Mari-Alexandre, Juan Gilabert-Estelles, Pilar Medina, Martin Goette
Summary: Ovarian cancer has a high prevalence and mortality rate in women, often diagnosed at an advanced stage due to non-specific symptoms. The interaction between cancer cells and other molecules plays a crucial role in the development of the disease. Syndecans, a family of four transmembrane proteins, are dysregulated in various cancers, including ovarian cancer, and show promise as diagnostic and prognostic biomarkers. Additionally, studying these proteins in ovarian cancer could lead to the discovery of new drugs for treatment.
Review
Endocrinology & Metabolism
Mikahela A. Lopez-Morales, Maria Castello-Ruiz, Maria C. Burguete, David Hervas, Miguel A. Perez-Pinzon, Juan B. Salom
Summary: This systematic review evaluates the effects and mechanisms of Resveratrol (RSV) in animal models of ischemic stroke. The results show that RSV has beneficial effects on structural and functional outcomes, including reducing infarct size, edema size, BBB impairment, neurofunctional impairment, and improving motor performance. These effects may be attributed to the reduction of oxidative stress, inflammation, and apoptosis. However, further high-quality preclinical research is needed to better inform clinical research.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Hematology
Lucy de Lloyd, Peter Jenkins, Sarah F. Bell, Nicola J. Mutch, Julia Freyer Martins Pereira, Pilar M. Badenes, Donna James, Anouk Ridgeway, Leon Cohen, Thomas Roberts, Victoria Field, Rachel E. Collis, Peter W. Collins
Summary: This study investigated the hemostatic changes associated with postpartum hemorrhage (PPH). The results showed that clinically significant hemostatic impairment is uncommon during PPH, but a subgroup of women have a distinct and severe coagulopathy associated with poor fetal outcomes.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Health Care Sciences & Services
Alicia Garcia-Testal, Francisco Jose Martinez-Olmos, Jose Antonio Gil-Gomez, Victor Lopez-Tercero, Laura Lahoz-Cano, David Hervas-Marin, Alicia Cana-Poyatos, Rafael Garcia-Maset, Pilar Royo-Maicas, Eva Segura-Orti
Summary: The study aims to investigate the effects of virtual reality exercise during hemodialysis on hemodynamic control. The results showed that performing virtual reality exercise at the end of a hemodialysis session does not lead to hemodynamic instability.