4.6 Review

Autophagy Roles in Genome Maintenance

期刊

CANCERS
卷 12, 期 7, 页码 -

出版社

MDPI
DOI: 10.3390/cancers12071793

关键词

autophagy; DNA damage response; DNA damage repair; cancer therapy

类别

资金

  1. AIRC [I.G. 23066]
  2. FIRC-AIRC

向作者/读者索取更多资源

In recent years, a considerable correlation has emerged between autophagy and genome integrity. A range of mechanisms appear to be involved where autophagy participates in preventing genomic instability, as well as in DNA damage response and cell fate decision. These initial findings have attracted particular attention in the context of malignancy; however, the crosstalk between autophagy and DNA damage response is just beginning to be explored and key questions remain that need to be addressed, to move this area of research forward and illuminate the overall consequence of targeting this process in human therapies. Here we present current knowledge on the complex crosstalk between autophagy and genome integrity and discuss its implications for cancer cell survival and response to therapy.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据