Article
Ophthalmology
Trine M. Jakobsen, Anders P. Sondergaard, Flemming Moller
Summary: This study aimed to investigate changes in peripheral and relative peripheral refraction during orthokeratology lens use in children. Results showed that orthokeratology lens wear induced significant myopic relative peripheral refraction, but only changed peripheral refraction in two eccentric measuring points. Furthermore, baseline peripheral refraction, on-axis refraction, and relative peripheral refraction at 30 degrees nasal eccentricity were correlated with treatment efficacy.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Erin S. Tomiyama, David A. Berntsen, Kathryn Richdale
Summary: This study aimed to compare the effects of toric orthokeratology (TOK) and soft toric multifocal (STM) contact lenses on peripheral refraction in patients with astigmatism and myopia. The results showed that TOK induced greater myopic shift and astigmatism compared to STM, which may impact the efficacy of myopia management.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Jost B. Jonas, Marcus Ang, Pauline Cho, Jeremy A. Guggenheim, Ming Guang He, Monica Jong, Nicola S. Logan, Maria Liu, Ian Morgan, Kyoko Ohno-Matsui, Olavi Parssinen, Serge Resnikoff, Padmaja Sankaridurg, Seang-Mei Saw, Earl L. Smith, Donald T. H. Tan, Jeffrey J. Walline, Christine F. Wildsoet, Pei-Chang Wu, Xiaoying Zhu, James S. Wolffsohn
Summary: The prevalence of myopia is increasing in East and Southeast Asia, with strategies needed to reduce its progression. Encouraging outdoor activities and using low-dose atropine eye drops are beneficial measures for reducing myopia development. Individual risk-to-benefit ratios need to be considered for different treatment options based on age, health, and lifestyle.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Clinical Neurology
Xiaohang Chen, Yan Xiong, Xinzhou Qi, Longqian Liu
Summary: The objective of this study was to observe the changes in peripheral refraction in myopic adolescents after overnight orthokeratology and its influencing factors. The results showed that after wearing orthokeratology lenses, the relative peripheral refraction in myopic patients changed from relative hyperopia to relative myopia, and the nasal-temporal asymmetry also changed significantly. This change was correlated with the baseline refractive state.
FRONTIERS IN NEUROLOGY
(2023)
Article
Ophthalmology
Qi Tan, Alex L. K. Ng, George P. M. Cheng, Victor C. P. Woo, Pauline Cho
Summary: This study found that combining 0.01% atropine with orthokeratology (AOK) has a better effect in retarding axial elongation compared to orthokeratology alone (OK). The study included 96 Chinese children aged 6 to 11 years with myopia and showed that the AOK group had significantly slower axial elongation compared to the OK group. The AOK group also exhibited larger pupil dilation and choroidal thickening.
CONTACT LENS & ANTERIOR EYE
(2023)
Review
Medicine, General & Internal
Yue Gao, Yan Yu
Summary: This study aimed to investigate the effect of 0.01% atropine on ocular axial elongation in myopic children. The meta-analysis found that the combination of orthokeratology and 0.01% atropine can effectively control myopia progression, providing helpful evidence for its effectiveness.
Review
Medicine, General & Internal
Hou-Ren Tsai, Jen-Hung Wang, Huei-Kai Huang, Tai-Li Chen, Po-Wei Chen, Cheng-Jen Chiu
Summary: This study compared the efficacy of atropine, Ortho-K, and combined atropine with Ortho-K for childhood myopia through a network meta-analysis. The results showed that different dosages of atropine and combined treatment could effectively slow down myopic progression, and the efficacy of atropine was dose-related. Additionally, Ortho-K and low-dose atropine had similar efficacy, and the combination of 0.01% atropine with Ortho-K had comparable efficacy to high-dose atropine.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Review
Pharmacology & Pharmacy
Alberto Chierigo, Lorenzo Ferro Desideri, Carlo Enrico Traverso, Aldo Vagge
Summary: Several approaches have been investigated to prevent myopia progression in children and teenagers, among them, topical atropine has shown promising results. However, the optimal formulation and treatment algorithm have yet to be determined. Further larger-scale studies are needed to characterize the clinical efficacy of atropine and define the optimal dosage and treatment regimen.
Article
Ophthalmology
Yong Lyu, Na Ji, Ai-Cun Fu, Wei-Qun Wang, Li Wei, Jian Qin, Bing-Xin Zhao
Summary: The study concluded that orthokeratology seems to be a more effective method for controlling axial length elongation in children with myopia, especially in those with higher levels of myopia, compared to the administration of 0.02% atropine eye drops over a 2-year treatment period.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Ophthalmology
Wenchen Zhao, Zhouyue Li, Yin Hu, Jinyun Jiang, Wen Long, Dongmei Cui, Weiyin Chen, Xiao Yang
Summary: The study explored the one-month change in subfoveal choroidal thickness (SFChT) of myopic children treated with 0.01% atropine, orthokeratology (OK), or their combination. Results showed a significant increase in SFChT in the ACO, OK, and atropine groups, while it decreased in the control group. The combination of orthokeratology and atropine led to a greater increase in SFChT compared to monotherapy with atropine, suggesting a potentially more effective treatment for childhood myopia control.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Zhi Chen, Zhe Zhang, Feng Xue, Jiaqi Zhou, Li Zeng, Xiaomei Qu, Xingtao Zhou
Summary: This study investigated the relationship between myopia progression and axial length elongation in orthokeratology patients. The results showed that myopia significantly progressed and axial length increased after ortho-k treatment, and this progression was related to changes in corneal curvature, baseline age, and duration of treatment.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Ophthalmology
Donald O. Mutti, Loraine T. Sinnott, David A. Berntsen, Lisa A. Jones-Jordan, Danielle J. Orr, Jeffrey J. Walline
Summary: This study compared axial and peripheral eye elongation during myopia therapy with multifocal soft contact lenses. The findings suggest that wearing +2.50 D addition multifocal contact lenses can neutralize or reverse the increase in retinal steepness caused by single vision lenses.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Linlin Du, Jun Chen, Li Ding, Jingjing Wang, Jinliuxing Yang, Hui Xie, Xun Xu, Xiangui He, Mengjun Zhu
Summary: This study aimed to assess the effectiveness of combining orthokeratology (OK) and low-concentration atropine for myopia control in children. The results showed that the combination treatment could effectively suppress axial elongation, especially in younger children.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
William Myles, Catherine Dunlop, Sally A. McFadden
Summary: Low-dose atropine can slow the progression of myopia in children, especially in the 'slow' progression group. However, rebound occurred in three-quarters of eyes after cessation of atropine. Adverse effects were observed in 69% of patients, with dilated pupils being more common in children with blue eyes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Ophthalmology
Antonio Medina
Summary: This article reviews the key findings and current knowledge of the cause of myopia and proposes a prevailing theory and applicable action. Myopia has become an epidemic, with an estimated half of the world's population projected to be myopic by 2050 unless new strategies are developed. The article explores the connection between myopia development and the feedback theory of emmetropization, discussing observed factors such as near work, corrective lenses, and outdoor activities. The key findings suggest that myopia is the result of corrective lenses interfering with emmetropization. Sufficient knowledge exists to answer the question of whether myopia can be reversed or prevented.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Davide Borroni, Chiara Bonzano, Jose-Maria Sanchez-Gonzalez, Rahul Rachwani-Anil, Francisco Zamorano-Martin, Jorge Pereza-Nieves, Carlo Enrico Traverso, Maria Garcia Lorente, Marina Rodriguez-Calvo-de-Mora, Alfonso Esposito, Fernando Godin, Carlos Rocha-de-Lossada
Summary: Shotgun metagenomics analysis was used to evaluate the microbiota of culture negative Corneal Impression Membrane (CIM) microbial keratitis samples. The study found that Brevundimonas diminuta was present in 5 samples, viral infections were detected in 6 samples, and Cutibacterium acnes, Staphylococcus aureus, Moraxella lacunata, and Pseudomonas alcaligenes were identified as the presumed putative cause of infection in 7 samples.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Antonio Ballesteros-Sanchez, Beatriz Gargallo-Martinez, Maria Carmen Sanchez-Gonzalez, Jose-Maria Sanchez-Gonzalez
Summary: The combination of intense pulse light (IPL) and low-level light therapy (LLLT) shows improvement in symptoms and signs of dry eye disease (DED). Results from relevant studies indicate that this treatment decreases the Ocular Surface Disease Index (OSDI) score, meibomian gland dysfunction (MGD) score, MGD grade, and meiboscore, while increasing tear film stability, lipid layer thickness, and loss area of the meibomian gland. However, the effects on tear volume, tear meniscus height, and Schirmer test are inconclusive.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2023)
Letter
Ophthalmology
Raul Capote-Puente, Petar Eftimov, Maria-Jose Bautista-Llamas, Norihiko Yokoi, Jose-Maria Sanchez-Gonzalez, Georgi Georgiev
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Biology
Alfredo Lopez-Munoz, Beatriz Gargallo-Martinez, Maria Carmen Sanchez-Gonzalez, Raul Capote-Puente, Concepcion De-Hita-Cantalejo, Marta Romero-Luna, Juan-Jose Conejero-Dominguez, Jose-Maria Sanchez-Gonzalez
Summary: The aim of this study was to evaluate the relationship between myopia and ocular biometric variables. The Pentacam AXL((R)) single rotation Scheimpflug camera was used for this study. The results showed that axial length (AXL) had a significant correlation with spherical equivalent without cycloplegia (SE), age at onset of myopia, mean keratometry (Km), anterior chamber depth (ACD), and corneal horizontal diameter (WTW). AXL was found to have the greatest influence on the final refractive state in adult myopic eyes.
Review
Biology
Maria Carmen Sanchez-Gonzalez, Estanislao Gutierrez-Sanchez, Jose-Maria Sanchez-Gonzalez, Concepcion De-Hita-Cantalejo, Ana-Maria Pinero-Rodriguez, Timoteo Gonzalez-Cruces, Raul Capote-Puente
Summary: Presbyopia is a condition where the eye's ability to focus on near objects decreases, leading to difficulty in sustaining clear vision. It is estimated that by 2030, around 2.1 billion people will be affected by presbyopia. Corneal inlays are a potential solution for correcting presbyopia, involving the implantation of a small device beneath the cornea. However, postoperative complications such as corneal fibrosis, epithelial iron deposits, and stromal haze have been reported.
Article
Ophthalmology
Antonio Ballesteros-Sanchez, Beatriz Gargallo-Martinez, Ramon Gutierrez-Ortega, Jose-Maria Sanchez-Gonzalez
Summary: This study aimed to evaluate the intraobserver repeatability of automated, objective, and noninvasive measurements obtained with the S390L Firefly WDR slitlamp. Multiple variables were measured in 50 eyes of dry eye disease patients. The results showed that all variables except L-MGD grade had no statistically significant differences in repeated-measures analysis. F-NIBUT and A-NIBUT had the poorest repeatability, while the remaining variables showed satisfactory repeatability.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2023)
Review
Ophthalmology
Celia Garcia-Lopez, Marina Rodriguez-Calvo-de-Mora, Davide Borroni, Jose-Maria Sanchez-Gonzalez, Vito Romano, Carlos Rocha-de-Lossada
Summary: During infectious keratitis, the overexpression of MMPs, particularly MMP-2 and MMP-9, leads to the degradation of corneal collagen and can cause complications. Nonspecific treatments like tetracyclines and corticosteroids are used as adjuvants to antimicrobials to alleviate corneal degradation and inflammation. Specific MMP inhibitors, pro-MMP activator inhibitors, and anti-cytokine agents have also been reported. Further studies are needed to investigate the potential of these treatments in managing infectious keratitis.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Immunology
Alberto Sanchez-Mellado, Luis Alcaraz-Clemente, Marina Rodriguez-Calvo-de-Mora, Jose-Maria Sanchez-Gonzalez, Santiago Ortiz-Perez, Carlos Rocha-de-Lossada
Summary: There are two authorized vaccines for herpes zoster (HZ), Zostavax and Shingrix, which have proven to be safe and effective. Ophthalmologists play an important role in advocating for vaccination against HZ due to their work with vision-threatening complications. A survey was conducted among Spanish ophthalmologists to assess their knowledge of the available vaccines and it revealed lack of awareness and low rates of vaccination recommendation. It is crucial for ophthalmologists to take an active role in HZ prevention due to the consequences of the disease and the availability of effective vaccines.
Article
Medicine, General & Internal
Jose-Maria Sanchez-Gonzalez, Carmen Silva-Viguera, Maria Carmen Sanchez-Gonzalez, Raul Capote-Puente, Concepcion De-Hita-Cantalejo, Antonio Ballesteros-Sanchez, Lydia Ballesteros-Duran, Marta-C. Garcia-Romera, Estanislao Gutierrez-Sanchez
Summary: This study evaluated the effectiveness of hyaluronic acid and trehalose eyedrops in managing dry eye disease symptoms. The results showed that using hyaluronic acid and trehalose eyedrops can significantly improve tear stability and reduce dry eye symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Carlos Rocha-de-Lossada, Cosimo Mazzotta, Federico Gabrielli, Filomena Tiziana Papa, Carmen Gomez-Huertas, Celia Garcia-Lopez, Facundo Urbinati, Rahul Rachwani-Anil, Maria Garcia-Lorente, Jose-Maria Sanchez-Gonzalez, Miguel Rechichi, Giovanni Rubegni, Davide Borroni
Summary: This study utilized the mNGS 16S rRNA sequencing method to investigate the ocular microbiota of keratoconus patients who had not undergone any surgical treatment. The findings suggest that alterations in the microbiota may play a role in the development of keratoconus.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Julia Hernandez-Lucena, Federico Alonso-Aliste, Jonatan Amian-Cordero, Jose-Maria Sanchez-Gonzalez
Summary: This study investigated the effects of Laser Blended Vision (LBV) on binocular summation and stereopsis in the treatment of presbyopia and hyperopia. The results showed that stereopsis quality significantly influenced short-term post-operative visual outcomes, but its impact diminished over time, becoming statistically insignificant at the 12-month post-operative mark. Future studies are needed to understand the enduring clinical ramifications of these observations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Antonio Ballesteros-Sanchez, Concepcion De-Hita-Cantalejo, Maria Carmen Sanchez-Gonzalez, Maria-Jose Bautista-Llamas, Jose-Maria Sanchez-Gonzalez, Beatriz Gargallo-Martinez
Summary: The purpose of this study was to analyze the choroidal thickness in keratoconus patients undergoing cross-linking treatment compared to a healthy population and determine the factors influencing choroidal thickness. Choroidal thickness was measured at different locations using optical coherence tomography. The results showed that choroidal thickness was significantly greater in keratoconus patients than in healthy individuals. Age and refractive error were not found to be associated with choroidal thickness.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Correction
Ophthalmology
Antonio Ballesteros-Sanchez, Concepcion De-Hita-Cantalejo, Maria Carmen Sanchez-Gonzalez, Maria-Jose Bautista-Llamas, Jose-Maria Sanchez-Gonzalez, Beatriz Gargallo-Martinez
INTERNATIONAL OPHTHALMOLOGY
(2023)
Review
Medicine, General & Internal
Antonio Ballesteros-Sanchez, Maria Carmen Sanchez-Gonzalez, Concepcion De-Hita-Cantalejo, Estanislao Gutierrez-Sanchez, Carlos Rocha-de-Lossada, Jose-Maria Sanchez-Gonzalez, Atsushi Mizota
Summary: This paper evaluates the efficacy and safety of Rebamipide (REB) ophthalmic suspension in the treatment of dry eye disease (DED). The results show that REB ophthalmic suspension significantly improves dry eye-related quality of life score, tear film break-up time, Schirmer test, and total corneal fluorescein staining. The occurrence of adverse events is low and overall compliance is high.
JOURNAL OF CLINICAL MEDICINE
(2023)
