CD8+CD57+ T cells exhibit distinct features in human non-small cell lung cancer

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

(2019) Zeyu Chen et al.   IMMUNITY

High OX-40 expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer

(2019) Erminia Massarelli et al.   Journal for ImmunoTherapy of Cancer

CD103 + CD8 + T lymphocytes in non-small cell lung cancer are phenotypically and functionally primed to respond to PD-1 blockade

(2018) Peiliang Wang et al.   CELLULAR IMMUNOLOGY

T-bet and Eomes govern differentiation and function of mouse and human NK cells and ILC1

(2018) Jiang Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial

(2018) John M Wrangle et al.   LANCET ONCOLOGY

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses

(2018) Rosa M. Santana Carrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

(2017) Alexander C. Huang et al.   NATURE

Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

(2017) Alice O. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy?

(2017) Sylvain Simon et al.   OncoImmunology

Image Analysis-based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non-small Cell Lung Carcinoma Patients

(2016) E. R. Parra et al.   CLINICAL CANCER RESEARCH

IL-15 boosts the function and migration of human terminally differentiated CD8+T cells by inducing a unique gene signature

(2016) Ruka Setoguchi   INTERNATIONAL IMMUNOLOGY

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

(2016) Alena Gros et al.   NATURE MEDICINE

CD8 + T Lymphocyte Self-Renewal during Effector Cell Determination

(2016) Wen-Hsuan W. Lin et al.   Cell Reports

Inflammatory IL-15 is required for optimal memory T cell responses

(2015) Martin J. Richer et al.   JOURNAL OF CLINICAL INVESTIGATION

Effective effector generation of CD8 + T cells and NK cells: A need for T-bet and ZEB-too

(2015) Sara E. Hamilton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

PD-1+ CD8+ T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients

(2014) X Wu et al.   BRITISH JOURNAL OF CANCER

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

(2014) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Network Pipeline Reveals Genetic Determinants Associated with in Situ Lymphocyte Proliferation and Survival of Cancer Patients

(2014) B. Mlecnik et al.   Science Translational Medicine

Checkpoint Blockade Immunotherapy Relies on T-bet but Not Eomes to Induce Effector Function in Tumor-Infiltrating CD8+ T Cells

(2014) M. M. Berrien-Elliott et al.   Cancer Immunology Research

From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality

(2013) Anis Larbi et al.   CYTOMETRY PART A

The who's who of T-cell differentiation: Human memory T-cell subsets

(2013) Yolanda D. Mahnke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Detection and Characterization of a Novel Subset of CD8+CD57+ T Cells in Metastatic Melanoma with an Incompletely Differentiated Phenotype

(2012) R. C. Wu et al.   CLINICAL CANCER RESEARCH

Cutting Edge: Virus-Specific CD8+ T Cell Clones and the Maintenance of Replicative Function during a Persistent Viral Infection

(2010) O. Bannard et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

(2010) A. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Clinical Significance of Tumor-Infiltrating Lymphocytes in Lung Neoplasms

(2009) Enrico Ruffini et al.   ANNALS OF THORACIC SURGERY

CD57+ T lymphocytes and functional immune deficiency

(2009) Daniele Focosi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phenotype and function of human T lymphocyte subsets: Consensus and issues

(2008) Victor Appay et al.   CYTOMETRY PART A

Prognostic value of CD57+ T lymphocytes in the peripheral blood of patients with advanced gastric cancer

(2008) Junji Akagi et al.   International Journal of Clinical Oncology

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

(2008) D. G. Brooks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA