Development of a potent Zika virus vaccine using self-amplifying messenger RNA

Novel Vaccine Technologies

(2018) Barney S. Graham et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

An inhibitor screen identifies histone-modifying enzymes as mediators of polymer-mediated transgene expression from plasmid DNA

(2018) Matthew D. Christensen et al.   JOURNAL OF CONTROLLED RELEASE

Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials

(2018) Martin R Gaudinski et al.   LANCET

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

(2018) Annette B. Vogel et al.   MOLECULAR THERAPY

The Many Faces of a Dynamic Virion: Implications of Viral Breathing on Flavivirus Biology and Immunogenicity

(2018) Kimberly A. Dowd et al.   Annual Review of Virology

Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design

(2017) Timothy Pepini et al.   JOURNAL OF IMMUNOLOGY

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

(2017) Norbert Pardi et al.   NATURE

Structure of the immature Zika virus at 9 Å resolution

(2017) Vidya Mangala Prasad et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine — Preliminary Report

(2017) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure of the immature Zika virus at 9 Å resolution

(2017) Vidya Mangala Prasad et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Incorporation of a Nuclear Localization Signal in pH Responsive LAH4-L1 Peptide Enhances Transfection and Nuclear Uptake of Plasmid DNA

(2016) Yingying Xu et al.   MOLECULAR PHARMACEUTICS

Rapid development of a DNA vaccine for Zika virus

(2016) K. A. Dowd et al.   SCIENCE

Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

(2016) P. Abbink et al.   SCIENCE

Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype

(2016) Kimberly A. Dowd et al.   Cell Reports

Possible Association Between Zika Virus Infection and Microcephaly — Brazil, 2015

(2016) Lavinia Schuler-Faccini et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine

(2016) Karuppiah Muthumani et al.   npj Vaccines

Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin

(2015) Michela Brazzoli et al.   JOURNAL OF VIROLOGY

Recognition determinants of broadly neutralizing human antibodies against dengue viruses

(2015) Alexander Rouvinski et al.   NATURE

Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014

(2014) M Besnard et al.   Eurosurveillance

DNA vaccines: A safe and efficient platform technology for responding to emerging infectious diseases

(2014) Julie E. Ledgerwood et al.   Human vaccines & immunotherapeutics

Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion

(2014) W. M. Bogers et al.   JOURNAL OF INFECTIOUS DISEASES

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

(2014) Wanwisa Dejnirattisai et al.   NATURE IMMUNOLOGY

RNA: The new revolution in nucleic acid vaccines

(2013) Andrew J. Geall et al.   SEMINARS IN IMMUNOLOGY

Rapidly produced SAM® vaccine against H7N9 influenza is immunogenic in mice

(2013) Armin Hekele et al.   Emerging Microbes & Infections

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear localization signal sequence of porcine circovirus type 2 ORF2 enhances intracellular delivery of plasmid DNA

(2011) Hsu-Chung Gabriel Chen et al.   ARCHIVES OF VIROLOGY

A West Nile Virus DNA Vaccine Utilizing a Modified Promoter Induces Neutralizing Antibody in Younger and Older Healthy Adults in a Phase I Clinical Trial

(2011) Julie E. Ledgerwood et al.   JOURNAL OF INFECTIOUS DISEASES

Zika Virus Outbreak on Yap Island, Federated States of Micronesia

(2009) Mark R. Duffy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development

(2008) Theodore C. Pierson et al.   Cell Host & Microbe