期刊
PHYSIOLOGY INTERNATIONAL
卷 107, 期 2, 页码 220-230出版社
AKADEMIAI KIADO ZRT
DOI: 10.1556/2060.2020.00020
关键词
insulin-like growth factor I; follistatin; myostatin; cross-sectional area; muscle growth
类别
Objective: It has been shown that high-intensity interval training (HIIT) leads to skeletal muscle hypertrophy; however, its mechanisms of cellular and molecular regulation are still unclear. The purpose of this study was to investigate the effect of HIIT on muscle hypertrophy and major signal transduction pathways. Design: 12 male rats were randomly divided into two groups: control and HIIT. The exercise group performed 30-min HIIT in each session (5 X 4-min intervals running at 85 95% VO2max separated by 2-min active rest at 55-60% VO2max), 3 days/week for 8 weeks. Muscle fiber cross-sectional area (CSA) and the expression of signal transduction pathway proteins were determined in the gastrocnemius muscle. Results: In the HIIT group, the expression of IGF-I, IGF-IR Akt, p-Akt, AMPK alpha, p-AMPK alpha and follistatin increased significantly, whereas a significant decrease was observed in the expression of FoxO1, p-FoxO1, myostatin, ActRIIB, Smad2/3 and p-Smad2/3 (P < 0.05). However, there were no significant differences between the HIIT and control groups in the expression of mTOR, p-mTOR, P70S6K, and p-P70S6K (P > 0.05). In addition, CSA and gastrocnemius muscle weight increased significantly in the HIIT group (P < 0.05). Conclusions: HITT induced muscle hypertrophy by improving IGF-I/Akt/FoxO and myostatin/Smad signal transduction pathways.
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