Article
Chemistry, Physical
Ling Cai, Yanqiang Huang, Yuanyuan Duan, Qiao Liu, Qilan Xu, Jia Jia, Jianming Wang, Qian Tong, Peipei Luo, Yujie Wen, Luming Peng, Qian Wu, Xudong Hang, Huijun Jiang, Ping Zhu, Yanmei Yang, Boshen Zhou, Liping Zeng, Hongkai Bi, Jin Chen
Summary: This study introduces a novel Schiff-based silver nanocomplex with broad-spectrum antimicrobial activity, including prevention of drug resistance, and demonstrates superior in vivo fungicidal efficacy compared to traditional antifungal drugs.
Article
Pharmacology & Pharmacy
Luis Filipe, Telma de Sousa, Dario Silva, Miguel M. Santos, Manuela Ribeiro Carrott, Patricia Poeta, Luis C. Branco, Sandra Gago
Summary: The combination of active pharmaceutical ingredients in the form of ionic liquids or organic salts (API-OSILs) with mesoporous silica nanoparticles (MSNs) as drug carriers can enhance the capabilities of current antibiotics, especially against resistant strains of bacteria. In this study, three nanomaterials based on the modification of MSN surface with different ionic liquids coupled with anionic ciprofloxacin were prepared. These materials showed no cytotoxicity and exhibited improved antibacterial activity against both resistant and sensitive strains of K. pneumoniae. One particular nanomaterial, [MSN-Chol][Cip], showed significant enhancement with a tenfold decrease in MIC against sensitive strains. The importance of this study is rated at 8 out of 10 for its potential application in combating antibiotic resistance.
Article
Chemistry, Multidisciplinary
Shuang Wu, Yi Huang, Jiachang Yan, Yuzhen Li, Jinfeng Wang, Yi Yan Yang, Peiyan Yuan, Xin Ding
Summary: This study introduces a biomimetic nanodelivery system consisting of outer membrane vesicles isolated from E. coli as shell and rifampicin-loaded mesoporous silica nanoparticles as core, aiming to enhance bacterial targeting and uptake, thus improving antimicrobial activity against Gram-negative bacteria.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Sheng He, Leon G. Leanse, Yanfang Feng
Summary: In the era of antimicrobial resistance, infectious diseases have become significant global burdens that urgently require innovative treatment strategies. Emerging studies have shown that artificial intelligence can transform drug delivery to promote effective treatment of infectious diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Periyanaina Kesika, Natarajan Suganthy, Chaiyavat Chaiyasut
Summary: Complete recovery from infection, sepsis, injury, or trauma requires a vigorous inflammatory response. Nanoparticles have become an efficient medical tool for diagnosing, preventing, and treating diseases due to their unique interactions with biological molecules. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy and have several advantages such as easy synthesis, loading, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases.
Article
Nanoscience & Nanotechnology
Iris Garrido-Cano, Anna Adam-Artigues, Ana Lameirinhas, Juan F. F. Blandez, Vicente Candela-Noguera, Ana Lluch, Begona Bermejo, Felix Sancenon, Juan Miguel Cejalvo, Ramoin Martinez-Manez, Pilar Eroles
Summary: Despite advances in breast cancer treatment, it remains the leading cause of cancer-related death in women worldwide. In this study, a nanodevice using mesoporous silica nanoparticles for miR-200c-3p delivery was designed and validated. The nanodevice demonstrated biocompatibility, escape ability from endosomes/lysosomes, and inhibition of tumor progression, invasion, migration, and proliferation in vitro. In vivo experiments confirmed tumor targeting, effective miR-200c-3p delivery, therapeutic efficacy with reduced tumor size and lung metastasis, and no signs of toxicity. Overall, miR-200c-3p-loaded nanoparticles present a potential strategy for breast cancer therapy and safe tumor-targeted delivery of microRNAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Joana Galhano, Goncalo A. Marcelo, Maria Paula Duarte, Elisabete Oliveira
Summary: Dual loading of drugs on mesoporous silica nanoparticles can increase the efficacy against resistant bacteria, especially in cancer patients who are highly susceptible to bacterial infections.
BIOORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Afsaneh Najafi, Pegah Khosravian, Majid Validi, Mohammad Porgham Daryasari, Fatemeh Drees, Abolfazl Gholipour
Summary: The study successfully synthesized mesoporous silica nanoparticles loaded with cefepime and meropenem, showing better antimicrobial activity against MDR A. baumannii isolates compared with free drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pediatrics
Stephen M. Reingold, Zachi Grossman, Adamos Hadjipanayis, Stefano Del Torso, Arunas Valiulis, Lukasz Dembinski, Shai Ashkenazi
Summary: This study aimed to survey the current situation of pediatric ASPs in European countries and establish a baseline for future attempts to harmonize pediatric ASPs and antibiotic use in Europe. The survey results showed that 74% of the surveyed countries had inpatient pediatric ASPs, and 48% had outpatient programs, but there were considerable variations in their composition and activities across countries.
FRONTIERS IN PEDIATRICS
(2023)
Article
Oncology
Etienne J. Slapak, Lily Kong, Mouad el Mandili, Rienk Nieuwland, Alexander Kros, Maarten F. Bijlsma, C. Arnold Spek
Summary: Systemic chemotherapy for pancreatic cancer is limited by toxicity-dependent dose restrictions, leading to premature termination of treatment. Targeted drug delivery using a protease-dependent system can reduce collateral toxicity and enhance efficacy by delivering chemotherapy drugs specifically to cancer cells without affecting healthy tissue. This study successfully demonstrated the feasibility of protease-mediated drug release in pancreatic cancer, highlighting the potential of this approach to improve treatment outcomes and reduce side effects.
Article
Pharmacology & Pharmacy
Sitah Alharthi, Zyta M. Ziora, Taskeen Janjua, Amirali Popat, Peter M. Moyle
Summary: This study aimed to develop synergistic therapies to treat superbug infections through the encapsulation of sortase A inhibitors into mesoporous silica nanoparticles. The results demonstrated that this encapsulation method significantly improved the solubility of the inhibitors and showed synergistic effects with antimicrobial peptides.
Review
Pharmacology & Pharmacy
Angela Cesaro, Shuangzhe Lin, Norbert Pardi, Cesar de la Fuente-Nunez
Summary: Antimicrobial peptides (AMPs) show potential as alternatives to traditional antibiotics, but face limitations such as susceptibility to proteases and off-site cytotoxicity. Designing suitable delivery systems can enhance the pharmacokinetic and pharmacodynamic profiles of AMPs.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Noor Akbar, Zara Aslam, Ruqaiyyah Siddiqui, Muhammad Raza Shah, Naveed Ahmed Khan
Summary: The study synthesized Zinc oxide nanoparticles conjugated with clinically-approved drugs, demonstrating significant antibacterial effects against multidrug-resistant bacteria, with Ceftriaxone and Ampicillin-conjugated ZnO-NPs showing the most potent effects.
Review
Biotechnology & Applied Microbiology
C. Santos, G. R. Rodrigues, L. F. Lima, M. C. G. dos Reis, N. B. Cunha, S. C. Dias, O. L. Franco
Summary: Antimicrobial peptides (AMPs) have shown specific actions on cell membrane and can be effective against drug-resistant infectious agents. The membrane-specificity of AMPs and their potential to combat drug-resistant microbes provide hope in the medical and therapeutic field. The high global death rate due to antimicrobial resistance (AMR) has led to the search for new molecules and product developments, primarily antibiotics. In addition to using multiple drugs, the synergistic action of AMPs and current antibiotic therapy has shown promise in treating difficult-to-treat infectious diseases caused by bacteria. This review highlights the recent advancements in medical and antibiotic therapy using AMP-based products and discusses the potential effects of using AMPs in combination with current drugs for the treatment of bacterial infectious diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Saurav Basu, Raul Copana, Ronaldo Morales, Suvaporn Anugulruengkitt, Thanyawee Puthanakit, Cecilia Maramba-Lazarte, Phoebe Williams, John Musembi, Mwanamvua Boga, Mohammad Issack, Adolfine Hokororo, Adegoke G. Falade, Indi Trehan, Elizabeth Molyneux, Tonya Arscott-Mills, Tinsae Alemayehu, Penelope A. Bryant
Summary: Antimicrobial resistance is a global health threat, and managing antibiotic use in LMIC is crucial. However, interventions in LMIC face limitations in resources, feasibility, and effectiveness. Gathering examples of antibiotic use problems and real-world solutions in LMIC can provide broader lessons for addressing antimicrobial resistance on a global scale.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Review
Chemistry, Applied
Jian Yao Ng, Sybil Obuobi, Mei Ling Chua, Chi Zhang, Shiqi Hong, Yogesh Kumar, Rajeev Gokhale, Pui Lai Rachel Ee
CARBOHYDRATE POLYMERS
(2020)
Article
Biotechnology & Applied Microbiology
Jian Yao Ng, Mei Ling Chua, Chi Zhang, Shiqi Hong, Yogesh Kumar, Rajeev Gokhale, Pui Lai Rachel Ee
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sybil Obuobi, Anna Ngoc Phung, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet
Summary: A series of zwitterionic nanoparticles containing nucleic acid nanostructures were fabricated for the delivery of vancomycin to combat Staphylococcus aureus biofilm infections. The modified nanoparticles showed improved performance in enhancing bacteria binding and biofilm penetration.
Article
Biochemistry & Molecular Biology
Edward Jianyang Lim, Eunice Goh Tze Leng, Nhan Dai Thien Tram, Mercy Halleluyah Periayah, Pui Lai Rachel Ee, Timothy Mark Sebastian Barkham, Zhi Sheng Poh, Navin Kumar Verma, Rajamani Lakshminarayanan
Summary: Due to high mortality and limited available antifungal drugs, there is a need to develop alternative therapies. This study investigated the effectiveness of four pore-forming antimicrobial peptides against clinically relevant pathogens and assessed their compatibility with human cells. Mastoparan B exhibited strong antifungal activity, while cecropin A was the least potent. These findings are important for the design and development of safe antifungal peptide-based drugs.
Article
Engineering, Biomedical
Viveka Kalidasan, Xin Yang, Ze Xiong, Renee R. Li, Haicheng Yao, Hareesh Godaba, Sybil Obuobi, Priti Singh, Xin Guan, Xi Tian, Selman A. Kurt, Zhipeng Li, Devika Mukherjee, Ravisankar Rajarethinam, Choon Seng Chong, Jiong-Wei Wang, Pui Lai Rachel Ee, Weiqiang Loke, Benjamin C. K. Tee, Jianyong Ouyang, Christopher J. Charles, John S. Ho
Summary: Monitoring surgical wounds post-operatively is crucial to prevent infections and complications. Multifilament surgical sutures with conductive polymer and capacitive sensors operated via radiofrequency identification can accurately monitor the physicochemical states of deep surgical sites.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Jian Yao Ng, Kee Ying Fremi Tan, Pui Lai Rachel Ee
Summary: This study reports the use of trehalose and gellan gum as biomacromolecules to create a cryopreservable and directly implantable hydrogel system for adipose-derived stem cell (ADSC) delivery. The encapsulated ADSCs showed adequate cryoprotection and demonstrated lower apoptosis rates compared to the current gold standard cryoprotectant.
Article
Chemistry, Multidisciplinary
A. Sousa, A. Ngoc Phung, N. Skalko-Basnet, S. Obuobi
Summary: Bacterial biofilms are resilient and cause chronic infections. Smart drug carriers are being explored as promising platforms to overcome antibiotic resistance. This review summarizes recent efforts in designing these smart carriers and provides insights into leveraging the biofilm microenvironment and external stimuli for efficient antimicrobial properties. The impact of carrier features on drug release profiles and potential toxicity are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Nhan Dai Thien Tram, Quy Thi Ngoc Tran, Jian Xu, Jeannie Ching Ting Su, Wupeng Liao, Wai Shiu Fred Wong, Pui Lai Rachel Ee
Summary: Due to the failure of target-specific strategies, a novel multifunctional biomaterial based on peptide nanonets has been developed to selectively trap lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in order to suppress inflammation and restore the antimicrobial activity of the last-resort antibiotic colistin. In addition to its ability to simultaneously trap and kill bacteria, the peptide nanonets have shown remarkable potential as a holistic anti-infective and anti-septic biomaterial.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Alexandra Sousa, Vegard Boroy, Agnethe Baeverud, Kjersti Julin, Annette Bayer, Morten Strom, Mona Johannessen, Natasa Skalko-Basnet, Sybil Obuobi
Summary: Nucleic acid-based materials have great potential for antimicrobial drug delivery. This study focuses on the stability and antibacterial properties of micellar nanocarriers derived from amphiphilic DNA strands against bacterial biofilms. By using a cationic amphiphilic antibiotic, the stability of the micelles is enhanced, their antibacterial activity remains intact, and they can penetrate bacterial biofilms and impact their metabolic activity. The PMB micelles are also highly safe and biocompatible, making them suitable for application against P. aeruginosa biofilm-colonized skin wounds.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Bettina Simone Fleck, Devika Mukherjee, Nhan Dai Thien Tram, Pui Lai Rachel Ee, Ute Schepers
Summary: This study found that short tetrameric peptoids composed of a balance of aromatic and lipophilic residues have potent selective antimicrobial activity against various microorganisms, including drug-resistant Staphylococcus aureus and mycobacteria. These peptoids also demonstrated cell-penetrating capabilities in HeLa and RAW 264.7 macrophage cells.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Nanoscience & Nanotechnology
Jian Yao Ng, Xiao Zhu, Devika Mukherjee, Chi Zhang, Shiqi Hong, Yogesh Kumar, Rajeev Gokhale, Pui Lai Rachel Ee
Summary: The combination of gellan gum and collagen to create a full interpenetrating network hydrogel has shown to enhance wound healing properties and promote regeneration by utilizing adipose-derived mesenchymal stem cells. The introduced hydrogel fabrication process demonstrated temperature-dependent simultaneous interpenetrating network, leading to improved mechanical properties and the ability to retain sufficient mass for cell-based therapy. Additionally, the incorporation of stem cells within the hydrogel structure showed increased stiffness and enhanced cell adhesion, ultimately resulting in successful application for burn wound therapy.
ACS APPLIED BIO MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Abigail A. Matthews, Pui Lai Rachel Ee, Ruowen Ge
MOLECULAR BIOMEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Sybil Obuobi, Venkatesh Mayandi, Nurul Azlyn Mohd Nor, Benedict Jiasheng Lee, Rajamani Lakshminarayanan, Pui Lai Rachel Ee