期刊
FRONTIERS IN NEUROLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fneur.2020.00847
关键词
MRI; Alzheimer; Parkinson; amyotrophic lateral sclerosis; frontotemporal dementia; cerebrovascular disease; stroke; cerebral small vessel disease
资金
- Ontario Neurodegenerative Disease Research Initiative, through the Ontario Brain Institute
- government of Ontario
- Baycrest Foundation
- Bruyere Research Institute
- Centre for Addiction and Mental Health Foundation
- London Health Sciences Foundation
- McMaster University Faculty of Health Sciences
- Ottawa Brain and Mind Research Institute
- Queen's University Faculty of Health Sciences
- Thunder Bay Regional Health Sciences Centre
- University of Ottawa Faculty of Medicine
- Windsor/Essex County ALS Association
- Temerty Family Foundation
The Ontario Neurodegenerative Research Initiative (ONDRI) is a 3 years multi-site prospective cohort study that has acquired comprehensive multiple assessment platform data, including 3T structural MRI, from neurodegenerative patients with Alzheimer's disease, mild cognitive impairment, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, and cerebrovascular disease. This heterogeneous cross-section of patients with complex neurodegenerative and neurovascular pathologies pose significant challenges for standard neuroimaging tools. To effectively quantify regional measures of normal and pathological brain tissue volumes, the ONDRI neuroimaging platform implemented a semi-automated MRI processing pipeline that was able to address many of the challenges resulting from this heterogeneity. The purpose of this paper is to serve as a reference and conceptual overview of the comprehensive neuroimaging pipeline used to generate regional brain tissue volumes and neurovascular marker data that will be made publicly available online.
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