Article
Orthopedics
Anna E. Kerschner, Daniel L. Huber, Benjamin L. Brett, Timothy B. Meier, Lindsay D. Nelson, Michael A. McCrea
Summary: This study examined the differences in return-to-play (RTP) practices between high school and collegiate athletes, finding that high school athletes may have longer symptom-free waiting periods (SFWPs). However, the symptom duration and total time to unrestricted RTP were comparable between the two levels.
CLINICAL JOURNAL OF SPORT MEDICINE
(2022)
Review
Neurosciences
Patryk A. Musko, Andreas K. Demetriades
Summary: Female athletes are more susceptible to sport-related concussions, especially in soccer. They experience more somatic symptoms such as headache, migraine, and sleep disturbance, and may require longer recovery time. The 6th ICSS does not extensively address sex differences, which are crucial for concussion management protocols in many sports.
Article
Oncology
Stuart J. McDonald, William T. O'Brien, Georgia F. Symons, Zhibin Chen, Jesse Bain, Brendan P. Major, Daniel Costello, Glenn Yamakawa, Mujun Sun, Rhys D. Brady, Biswadev Mitra, Richelle Mychasiuk, Terence J. O'Brien, Sandy R. Shultz
Summary: This study found that serum levels of NfL, GFAP, and tau in male Australian footballers can change significantly after concussion, and have diagnostic value. However, no differences in biomarkers were observed in female athletes after concussion. Further research is needed to investigate biomarker changes in concussed females.
BIOMARKER RESEARCH
(2021)
Article
Orthopedics
Stephen C. Bunt, Nyaz Didehbani, Tahnae Tarkenton, Heidi Rossetti, Cason Hicks, Bert Vargas, Cheryl Silver, Paul Nakonezny, Kathleen Bell, Hunt Batjer, C. Munro Cullum
Summary: This study revealed that adolescent female and male athletes may experience different symptoms after a sports-related concussion, with girls showing significantly higher severity of symptoms such as headache, dizziness, sensitivity to light and noise, and pressure in the head.
CLINICAL JOURNAL OF SPORT MEDICINE
(2021)
Article
Medicine, General & Internal
Etienne Gaudette, Seth A. Seabury, Nancy Temkin, Jason Barber, Anthony M. DiGiorgio, Amy J. Markowitz, Geoffrey T. Manley
Summary: This study assessed the employment and economic outcomes for working-age adults with mild traumatic brain injury (mTBI) in the 12 months after injury. It also explored the association between returning to work and employer assistance.
Review
Biochemistry & Molecular Biology
Matthew I. Hiskens, Tesfaye S. Mengistu, Katy M. Li, Andrew S. Fenning
Summary: This systematic review investigates the diagnostic or prognostic ability of microRNAs extracted from saliva in traumatic brain injury (TBI). Early data suggests that salivary microRNAs may assist with TBI diagnosis, but further research with consistent methods and larger patient populations is necessary to evaluate their diagnostic and prognostic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Ekta J. Shah, Katherine Gurdziel, Douglas M. Ruden
Summary: The study found that sex differences in traumatic brain injury outcomes and recovery in fruit flies are not dependent on the presence of Tau protein.
Article
Clinical Neurology
Michael E. Buckland, Andrew J. Affleck, Alan J. Pearce, Catherine M. Suter
Summary: This Perspective explores the evolution of understanding chronic traumatic encephalopathy (CTE) and its relationship with repetitive head injury. Unlike other neurodegenerative diseases, CTE has a distinct and modifiable risk factor: exposure to repetitive head injury. The current debate is fueled by immediate medico-legal concerns and the involvement of high-profile athletes.
FRONTIERS IN NEUROLOGY
(2022)
Review
Pediatrics
Tyler A. Tetreault, Sumeet Garg
Summary: Returning to physical activity is a concern for adolescents with idiopathic scoliosis after spinal fusion surgery. Previous studies have shown a decrease in flexibility post-surgery and the impact of fusion levels on returning to the same level of play. The safety of returning to activities is generally agreed upon, with rare complications reported. This review explores the function of fusion levels, factors influencing recovery, and safety considerations for returning to play post-spine surgery.
FRONTIERS IN PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Saef Izzy, Alexander Brown-Whalen, Taha Yahya, Aliyah Sarro-Schwartz, Gina Jin, Joon Yong Chung, Sevda Lule, Liza M. Morsett, Ali Alquraini, Limin Wu, Suzanne E. Hickman, Michael J. Whalen, Joseph El Khoury
Summary: The study found that repetitive closed head injury (rCHI) did not accelerate tau pathology and did not worsen behavioral outcomes in adolescent mice. However, rCHI induced microgliosis in the cortex and hippocampus and astrocytosis in the corpus callosum of P301S mice by 40 days post-injury. There were no significant microgliosis or astrocytosis observed in age-matched WT mice or sham-injured P301S mice after rCHI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Charlotte Oris, Julie Durif, Marion Rouzaire, Bruno Pereira, Damien Bouvier, Samy Kahouadji, Mathieu Abbot, Marina Brailova, Sylvain Lehmann, Christophe Hirtz, Philippe Decq, Bernard Dusfour, Nicola Marchi, Vincent Sapin
Summary: This study evaluated the use of seven blood biomarkers for sport-related concussions. Only S100B and GFAP remained stable over the course of a season. The individual percentage change of S100B and NFL concentrations measured 36 hours after concussion was significantly different between non-resolutive and resolutive cases.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Taylor M. Yeates, H. Gerry Taylor, Erin D. Bigler, Nori M. Minich, Ken Tang, Daniel M. Cohen, Ann Bacevice, Leslie K. Mihalov, Barbara Bangert, Nicholas A. Zumberge, Keith Owen Yeates
Summary: This study investigated sex differences in outcomes among children and adolescents presenting to the Emergency Department for mild traumatic brain injury or orthopedic injury. The results indicated that sex did not moderate cognitive ability or symptom presentation, but girls reported more somatic symptoms. The mild TBI group showed lower cognitive ability and higher symptoms compared to the orthopedic injury group in the acute phase.
JOURNAL OF NEUROTRAUMA
(2022)
Review
Clinical Neurology
Anat Biegon
Summary: Published epidemiological studies show that the number of women with TBI is significantly higher than previously believed, with young women being more likely to die from TBI compared to men in the same age group, but this reverses in postmenopausal women. Studies also indicate that female athletes who sustain mild TBI are more likely to report more symptoms than males.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychology, Multidisciplinary
Francisco Pradas, Victor Toro-Roman, Carlos Castellar, Luis Carrasco
Summary: The study found sex differences in the spatial distribution of serve and serve-return in elite table tennis players. Men more frequently served in zones 1 and 2, while women preferred zone 5. Men predominantly used the cut technique for the serve-return in zones 1 and 2, whereas women used it more from zone 5.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Neurosciences
Emily L. Dennis, David Baron, Brenda Bartnik-Olson, Karen Caeyenberghs, Carrie Esopenko, Frank G. Hillary, Kimbra Kenney, Inga K. Koerte, Alexander P. Lin, Andrew R. Mayer, Stefania Mondello, Alexander Olsen, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) is a leading cause of global disability, but predicting patient outcomes is challenging due to the heterogeneous nature of TBI in terms of injury severity and other factors. Neuroimaging research has been limited by small sample sizes, and the development of reliable biomarkers for mild TBI or repeated subconcussive impacts has been slow.
HUMAN BRAIN MAPPING
(2022)
Review
Clinical Neurology
Muhammad Ali Haidar, Hussam Jourdi, Zeinab Haj Hassan, Ohanes Ashekyan, Manal Fardoun, Zena Wehbe, Dina Maaliki, Maya Wehbe, Stefania Mondello, Samar Abdelhady, Shima Shahjouei, Maya Bizri, Yehia Mechref, Mark S. Gold, Ghassan Dbaibo, Hassan Zaraket, Ali H. Eid, Firas Kobeissy
Summary: SARS-CoV-2 infects cells through the ACE2 receptor and can affect the central nervous system, leading to symptoms such as dizziness, altered consciousness, and encephalitis. The virus may enter the brain tissue through various pathways, and the COVID-19 pandemic can exacerbate stress, depression, and anxiety in infected individuals and high-risk populations.
Review
Spectroscopy
Wenjing Peng, Cristian D. Gutierrez Reyes, Sakshi Gautam, Aiying Yu, Byeong Gwan Cho, Mona Goli, Kaitlyn Donohoo, Stefania Mondello, Firas Kobeissy, Yehia Mechref
Summary: Glycosylation is a significant posttranslational modification in mammalian cells, involved in various biofunctions and diseases. Mass spectrometry is a powerful tool for glycan and glycopeptide isomeric analysis, but its comprehensive characterization remains a challenge. Separation methods and bioinformatic tools are applied to address this challenge.
MASS SPECTROMETRY REVIEWS
(2023)
Article
Neurosciences
Maha Tabet, Marya El-Kurdi, Muhammad Ali Haidar, Leila Nasrallah, Mohammad Amine Reslan, Deborah Shear, Jignesh D. Pandya, Ahmed F. El-Yazbi, Mirna Sabra, Stefania Mondello, Yehia Mechref, Abdullah Shaito, Kevin K. Wang, Riyad El-Khoury, Firas Kobeissy
Summary: Traumatic brain injury (TBI) is a common and serious condition that leads to disability and death. Mild TBI (mTBI) represents the majority of cases, and repeated exposure to mTBI (rmTBI) can worsen symptoms. However, there is currently no approved drug for TBI or rmTBI. This study aimed to investigate the potential use of a mitochondria-targeted antioxidant, MitoQ, as a neurotherapy for rmTBI. The findings suggest that MitoQ can improve motor function and learning impairments caused by rmTBI, reduce inflammation, and increase antioxidant enzyme expression.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Firas Kobeissy, Khalil Mallah, Kazem Zibara, Fatima Dakroub, Zeinab Dalloul, Mohammad Nasser, Leila Nasrallah, Zahraa Mallah, Ghewa A. El-Achkar, Naify Ramadan, Wael Mohamed, Stefania Mondello, Hala Darwish, Eva Hamade, Aida Habib
Summary: Antiplatelet therapy with aspirin and/or clopidogrel has a dual effect in traumatic brain injury, increasing the risk of intracerebral haemorrhage while also providing neuroprotection.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Review
Clinical Neurology
Damir Janigro, Stefania Mondello, Jussi P. Posti, Johan Unden
Summary: Traumatic brain injury is a major global health issue with significant consequences. Early diagnosis of TBI through testing peripheral fluids has been the focus of research, leading to the development of clinical tools. However, unresolved issues still exist and further research and improvements are needed.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Michela Ripolone, Daniele Velardo, Stefania Mondello, Simona Zanotti, Francesca Magri, Elisa Minuti, Sara Cazzaniga, Francesco Fortunato, Patrizia Ciscato, Francesca Tiberio, Monica Sciacco, Maurizio Moggio, Paolo Bettica, Giacomo P. Comi
Summary: This study analyzed the histopathological characteristics of muscle biopsies in a large cohort of BMD patients and correlated them with functional impairment. The accurate quantification of fibroadipose tissue replacement and the identification of other histopathological aspects that correlate well with clinical performances were the most notable findings. These findings help improve our understanding of the histopathological progression of BMD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Pediatrics
Benedetta Armocida, Lorenzo Monasta, Susan Sawyer, Flavia Bustreo, Giulia Segafredo, Giulio Castelpietra, Luca Ronfani, Maja Pasovic, Simon Hay, Pablo Perel, David Beran
Summary: The burden of non-communicable diseases (NCDs) has decreased among adolescents in the EU between 1990 and 2019, but there is a concerning trend of increased years of life lost (YLL) and disability-adjusted life years (DALY) due to mental disorders. The differences by sex, age group, and EU Member States highlight the importance of preventive interventions and scaling up adolescent-responsive healthcare systems.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Clinical Neurology
Parmenion P. Tsitsopoulos, Stefania Mondello, Ulrika Holmstrom, Niklas Marklund
Summary: This study evaluated cerebrospinal fluid (CSF) biomarkers in patients with degenerative cervical spondylotic myelopathy (DCM) and found that CSF biomarker levels can reflect the severity of preoperative neurological status, correlate with radiological appearance, and correlate with clinical outcome. These findings suggest that CSF biomarkers may be a useful tool for assessing DCM severity and predicting outcomes after surgery.
Review
Public, Environmental & Occupational Health
Periklis Charalampous, Juanita A. Haagsma, Lea S. Jakobsen, Vanessa Gorasso, Isabel Noguer, Alicia Padron-Monedero, Rodrigo Sarmiento, Joao Vasco Santos, Scott A. McDonald, Dietrich Plass, Grant M. A. Wyper, Ricardo Assuncao, Elena von der Lippe, Balazs Adam, Ala'a AlKerwi, Jalal Arabloo, Ana Lucia Baltazar, Boris Bikbov, Maria Borrell-Pages, Iris Brus, Genc Burazeri, Serafeim C. Chaintoutis, Jose Chen-Xu, Nino Chkhaberidze, Seila Cilovic-Lagarija, Barbara Corso, Sarah Cuschieri, Carlotta Di Bari, Keren Dopelt, Mary Economou, Theophilus Emeto, Peter Fantke, Florian Fischer, Alberto Freitas, Juan Manuel Garcia-Gonzalez, Federica Gazzelloni, Mika Gissler, Artemis Gkitakou, Hakan Gulmez, Sezgin Gunes, Sebastian Haller, Romana Haneef, Cesar A. Hincapie, Paul Hynds, Jane Idavain, Milena Ilic, Irena Ilic, Gaetano Isola, Zubair Kabir, Maria Kamusheva, Pavel Kolkhir, Naime Meric Konar, Polychronis Kostoulas, Mukhtar Kulimbet, Carlo La Vecchia, Paolo Lauriola, Miriam Levi, Marjeta Majer, Enkeleint A. Mechili, Lorenzo Monasta, Stefania Mondello, Javier Munoz Laguna, Evangelia Nena, Edmond S. W. Ng, Paul Nguewa, Vikram Niranjan, Iskra Alexandra Nola, Ronan O'Caoimh, Marija Obradovic, Elena Pallari, Mariana Peyroteo, Vera Pinheiro, Nurka Pranjic, Miguel Reina Ortiz, Silvia Riva, Cornelia Melinda Adi Santoso, Milena Santric Milicevic, Tugce Schmitt, Niko Speybroeck, Maximilian Sprugel, Paschalis Steiropoulos, Aleksandar Stevanovic, Lau Caspar Thygesen, Fimka Tozija, Brigid Unim, Hilal Bektas Uysal, Orsolya Varga, Milena Vasic, Rafael Jose Vieira, Vahit Yigit, Brecht Devleesschauwer, Sara M. Pires
Summary: This systematic literature review provides an overview of studies applying the disability-adjusted life years (DALY) concept for infectious diseases in European countries. Among the 105 included studies, food- and water-borne diseases were the most frequently studied. The number of burden of infectious disease studies has increased over time, but there is less consensus in methodological approaches.
EPIDEMIOLOGY AND INFECTION
(2023)
Editorial Material
Clinical Neurology
Anastasia Bougea, Per Svenningsson, Ioanna Markaki, Abdul Hye, Stefania Mondello
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Akeem Sanni, Mona Goli, Jingfu Zhao, Junyao Wang, Chloe Barsa, Samer El Hayek, Farid Talih, Bartolo Lanuzza, Firas Kobeissy, Giuseppe Plazzi, Monica Moresco, Stefania Mondello, Raffaele Ferri, Yehia Mechref
Summary: This study aimed to identify potential serum biomarkers for narcolepsy type 1 (NT1), a life-threatening disorder characterized by a sleep-wake cycle disorder. A proteomics analysis was conducted, which revealed 36 differentially expressed proteins associated with NT1. These findings provide insights into the pathophysiological effects and important biochemical pathways involved in NT1.
Editorial Material
Clinical Neurology
Wael M. Y. Mohamed, Firas Kobeissy, Stefania Mondello
FRONTIERS IN NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sara Conti, Carla Fornari, Pietro Ferrara, Ippazio C. Antonazzo, Fabiana Madotto, Eugenio Traini, Miriam Levi, Achille Cernigliaro, Benedetta Armocida, Nicola L. Bragazzi, Ennio Cadum, Michele Carugno, Giacomo Crotti, Silvia Deandrea, Paolo A. Cortesi, Davide Guido, Ivo Iavicoli, Sergio Iavicoli, Carlo La Vecchia, Paolo Lauriola, Paola Michelozzi, Salvatore Scondotto, Massimo Stafoggia, Francesco S. Violante, Cristiana Abbafati, Luciana Albano, Francesco Barone-Adesi, Antonio Biondi, Cristina Bosetti, Danilo Buonsenso, Giulia Carreras, Giulio Castelpietra, Alberico Catapano, Maria S. Cattaruzza, Barbara Corso, Giovanni Damiani, Francesco Esposito, Silvano Gallus, Davide Golinelli, Simon I. Hay, Gaetano Isola, Caterina Ledda, Stefania Mondello, Paolo Pedersini, Umberto Pensato, Norberto Perico, Giuseppe Remuzzi, Francesco Sanmarchi, Rocco Santoro, Biagio Simonetti, Brigid Unim, Marco Vacante, Massimiliano Veroux, Jorge H. Villafane, Lorenzo Monasta, Lorenzo G. Mantovani
Summary: We investigated the temporal variations in disease burden of PM2.5 and ozone in Italy using data from the Global Burden of Disease Study 2019. The study found that while the burden of PM2.5 significantly decreased in Italy, the burden of ozone increased, even in the context of population aging.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Vivian A. Guedes, Sara Mithani, Cydni Williams, Dilorom Sass, Ethan G. Smith, Rany Vorn, Chelsea Wagner, Chen Lai, Jessica Gill, Holly E. Hinson
Summary: This study found differences in extracellular vesicle protein levels between TBI and non-TBI patients, suggesting that extracellular vesicle proteins may serve as potential biomarkers for TBI. However, further evaluation and longitudinal studies are needed to determine the clinical utility of these biomarkers.
NEUROTRAUMA REPORTS
(2022)
