HIV Reservoir Decay and CD4 Recovery Associated With High CD8 Counts in Immune Restored Patients on Long-Term ART

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals

(2019) Rémi Fromentin et al.   Nature Communications

CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques

(2019) Jin Fan et al.   Nature Communications

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

(2019) Nadine Bachmann et al.   Nature Communications

Programmed cell death-1 contributes to the establishment and maintenance of HIV-1 latency

(2018) Vanessa A. Evans et al.   AIDS

Mechanisms of CD8+ T cell-mediated suppression of HIV/SIV replication

(2018) Julia Bergild McBrien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plasma indoleamine 2,3-dioxygenase activity is associated with the size of HIV reservoir in patients receiving antiretroviral therapy

(2018) Jun Chen et al.   CLINICAL INFECTIOUS DISEASES

Human Immunodeficiency Virus (HIV)-Antibody Repertoire Estimates Reservoir Size and Time of Antiretroviral Therapy Initiation in Virally Suppressed Perinatally HIV-Infected Children

(2018) Salvatore Rocca et al.   Journal of the Pediatric Infectious Diseases Society

PD-1 Expression in HIV-Specific CD8+ T cells Before Antiretroviral Therapy Is Associated With HIV Persistence

(2018) Yanina Ghiglione et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Targeting Immune Checkpoint Molecules to Eliminate Latent HIV

(2018) Zoe Boyer et al.   Frontiers in Immunology

Combining CD4 recovery and CD4: CD8 ratio restoration as an indicator for evaluating the outcome of continued antiretroviral therapy: an observational cohort study

(2017) Shui Shan Lee et al.   BMJ Open

Asymptomatic CMV Replication During Early Human Immunodeficiency Virus (HIV) Infection Is Associated With Lower CD4/CD8 Ratio During HIV Treatment

(2016) Davey M. Smith et al.   CLINICAL INFECTIOUS DISEASES

Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications

(2016) Véronique Avettand-Fènoël et al.   CLINICAL MICROBIOLOGY REVIEWS

CD8 + Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy

(2016) Emily K. Cartwright et al.   IMMUNITY

Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression

(2016) Josephine Brice et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

HIV-specific CD8+ T cells and HIV eradication

(2016) R. Brad Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevation and persistence of CD8 T-cells in HIV infection: the Achilles heel in the ART era

(2016) Wei Cao et al.   Journal of the International AIDS Society

Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection

(2016) Matthias Hoffmann et al.   PLoS Pathogens

CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection

(2015) Michael L. Freeman et al.   CLINICAL INFECTIOUS DISEASES

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

HIV reservoirs: what, where and how to target them

(2015) Melissa J. Churchill et al.   NATURE REVIEWS MICROBIOLOGY

Post-treatment control of HIV infection

(2015) Jessica M. Conway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study

(2015) Cristina Mussini et al.   Lancet HIV

MSM and HIV-1 infection in China

(2015) Hong Shang et al.   National Science Review

HIV-1 DNA Decay Dynamics in Blood During More Than a Decade of Suppressive Antiretroviral Therapy

(2014) Guillaume J. Besson et al.   CLINICAL INFECTIOUS DISEASES

Course and Clinical Significance of CD8+T-Cell Counts in a Large Cohort of HIV-Infected Individuals

(2014) Marie Helleberg et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 DNA predicts disease progression and post-treatment virological control

(2014) James P Williams et al.   eLife

HIV Antibody Characterization as a Method to Quantify Reservoir Size During Curative Interventions

(2013) P. D. Burbelo et al.   JOURNAL OF INFECTIOUS DISEASES

Antiretroviral Therapy Initiated Within 6 Months of HIV Infection Is Associated With Lower T-Cell Activation and Smaller HIV Reservoir Size

(2013) Vivek Jain et al.   JOURNAL OF INFECTIOUS DISEASES

A novel acute HIV infection staging system based on 4th generation immunoassay

(2013) Jintanat Ananworanich et al.   Retrovirology

Integrated HIV DNA accumulates prior to treatment while episomal HIV DNA records ongoing transmission afterwards

(2012) John M. Murray et al.   AIDS

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

Cell-Based Measures of Viral Persistence Are Associated With Immune Activation and Programmed Cell Death Protein 1 (PD-1)–Expressing CD4+ T cells

(2012) Hiroyu Hatano et al.   JOURNAL OF INFECTIOUS DISEASES

CD4 Cell Count and the Risk of AIDS or Death in HIV-Infected Adults on Combination Antiretroviral Therapy with a Suppressed Viral Load: A Longitudinal Cohort Study from COHERE

(2012)   PLOS MEDICINE